TAMRON 585 SL Insecticide

SECTION 2: Hazards identification

dentures removed. The jaw should be supported and the patient placed in a face down position with the head down Toxicity class: WHO Ib; EPA I and turned to one side, with the tongue drawn forward. Methamidophos is a compound, which inhibits First aid should include, if necessary, mouth-to-nose cholinesterase enzyme activity in the nervous tissue. It is respiration, cardiac massage and avoidance of injury in of very high toxicity. Contact with skin, inhalation of dust or patients with trauma. spray, or swallowing may be fatal. Toxic to fish and bees. Inhalation: Remove source of contamination or move

Principle Routes of Exposure

May be absorbed from the victim to fresh air. Keep affected person warm and at rest. gastrointestinal tract, through the intact skin, and through Supply oxygen if necessary. Treat symptomatically and inhalation of fine spray mist or dust. supportively. Seek medical advice immediately. Eye contact: Highly toxic. Irritating to eyes. Skin contact: Remove contaminated clothing, shoes and Skin contact: Highly toxic, due to possible absorption. leather goods. Gently wipe of excess chemical. Wash Mildly irritating to skin. skin gently and thoroughly with water and non-abrasive soap. Seek medical advice if necessary. Persons who become sensitised may require specialised medical have a blocking effect on the neuromuscular junction. management with anti-inflammatory agents. Phenothiazines, reserpine and theophylline are Eye contact: Immediately flush eyes with gently flowing contraindicated in organophosphorous poisoning. cold water or saline solution for 15 to 20 minutes, holding the eyelid(s) open. Seek medical attention immediately. 5. FIRE FIGHTING MEASURES Ingestion: Have victim rinse mouth thoroughly with water. Do not induce vomiting, due to the aromatic solvent. Seek Fire and explosion hazard: Flammable. medical advice immediately. Extinguishing agents: Extinguish small fires with carbon Advice to physician: Atropine must be administered as dioxide, dry powder, or alcohol-resistant foam. For larger early as possible and could save lives, if given in time and fires, use water spray, fog or standard foam. in an adequate dosage. Patients with organophosphate Firefighting: Move containers from fire area if possible. poisoning require amounts of atropine far in excess of Fight fire from maximum distance. Stay away from storage doses usually employed in medical practice. The tank ends. Contain fire control water for later disposal. Do therapeutic objective is to achieve atropinisation, as not scatter material, extinguish only if flow can be stopped. evidenced by dilation of the pupils, drying secretion, pulse Use flooding amounts of water as a fog, solid streams may rate of over 120/min and flushing skin. To prevent be ineffective. Cool containers with flooding amounts of gastrointestinal absorption in the unconscious that have water as far a distance as possible. Use water spray to swallowed this product, perform stomach lavage using absorb toxic vapours. Avoid breathing toxic vapours. bicarbonate solution and activated charcoal. Keep upwind. Consider evacuation of downwind area if In less severe cases begin with 2 mg atropine material is leaking. intravenously for adults or 0.05 mg atropine/kg body Personal protective equipment: Fire may produce weight for children under 12 years of age and repeat irritating or poisonous vapours. Fire fighters and others that administration of the drug at 15 to 30 minutes intervals. may be exposed should wear full protective clothing and In severe cases a total atropine dose of 20 to 80 mg in the self-contained breathing apparatus. first hour may be necessary, with repeated drug administration at 3 to 10 minutes intervals. When signs of 6. ACCIDENTAL RELEASE MEASURES (SPILLAGE) atropinisation appear, the dose and frequency of administration should be reduced to a schedule that will Personal precautions: Avoid contact with skin and eyes. maintain full atropinisation for at least 24 hours. Over Do not breathe in dust or fumes. For personal protection dosage with atropine is rarely serious, but under dosage see Section 8. may be fatal in poisoning with organophosphorous Environmental precautions: Do not allow entering compounds. In any severe progressive case of poisoning drains or watercourses. When the product contaminates a cholinesterase reactivator e.g. pralidoxime (2PAM), if public waters, inform appropriate authorities immediately in available, should be administered, preferably within 8h accordance with local regulations. after intoxication. An average dose is 1 g for an adult (up Occupational spill: Do not touch spilled material. Stop to 50 mg/kg for children), usually given half as a single leak if you can do so without risk. Use water spray to intramuscular or intravenous injection and the other half as reduce vapours (contain any water used). Neutralise with an intravenous infusion with glucose and or saline. In sodium hydroxide and allow standing for 4 hours. For severe cases this treatment may be repeated in 1 to 2 small spills, sweep up with sand or other suitable hours, then at 10 to 12 hour intervals if needed, but not absorbent material, and place into containers for later beyond 24 hours, or 48 hours at the most. Pralidoxime disposal. Move containers from spill area. For larger spills, should be administered very slowly. If respiration is contain material far ahead of spill for later disposal. Keep depressed during or after injection, pulmonary ventilation spectators away. Isolate hazard area and deny entry. should be assisted mechanically. Ventilate closed spaces before entering. Toxogonin is a more recent cholinesterase reactivator. It can be administered instead of 2PAM at a dose of 250 mg intramuscularly for adults (4 to 8 mg/kg for children) and, if 7. HANDLING AND STORAGE REQUIREMENTS necessary, repeat after 1 to 2 hours. Diazepam should be included in the therapy of severe Handling: Highly toxic by absorption or if swallowed. cases and whenever convulsions appear. Doses of 5 to Avoid contact with eyes, prolonged contact with skin, and 10 mg for adults (2 to 5 mg for children) can be inhalation of dust and vapour. Use with adequate administered intravenously or subcutaneously or per ventilation. Wash hands before eating, drinking, chewing rectum, and repeated as required. gum, smoking, or using the toilet. Remove clothing NB: Because of their respiratory-depressant effects, immediately if the insecticide gets inside. Then wash skin morphine and similar drugs are contraindicated for thoroughly using a non-abrasive soap and put on clean patients poisoned with organophosphorous compounds. clothing. Do not apply directly to areas where surface Avoid aminoglycosides and succinylcholine, which water is present, or to intertidal areas below the mean high water mark. Water used to clean equipment must be dichloromethane <200 at 20 oC. g/ disposed of correctly to avoid contamination. isopropanol >200 at 20 oC. g/

Storage

The product must be kept under lock and key. hexane 0.1 to 1 at 20 oC. g/ Keep out of reach of unauthorised persons, children and toluene 2 to 5 at 20 oC. g/ animals. Store in its original labelled container in shaded, Partition-coefficient in n-octanol/water: well-ventilated area, away from heat, sparks and other Kow logP = -0.8 (Data for active ingredient) sources of ignition. Not to be stored next to foodstuffs and Flashpoint: 11,5 oC. water supplies. Local regulations should be complied with. Melting point Technical 20 to 25 oC 8. EXPOSURE CONTROL / PERSONAL PROTECTION 10. STABILITY AND REACTIVITY It is essential to provide adequate ventilation. The Stability: Stable at ambient temperature but decomposes measures appropriate for a particular work site depend on on heating without boiling. how this material is used and on the extent of exposure. Stable at pH 3 to 8. Ensure that control systems are properly designed and Hydrolysed in acids and alkalis. maintained. Comply with occupational safety, DT50 (22 oC): 1.8 year (pH 4), environmental, fire, and other applicable regulations. 120 hours (pH 7), Personal protective equipment: If engineering controls 70 hours (pH 9). and work practices are not effective in controlling exposure Photodegradation is of minor importance. to this material, then wear suitable personal protective equipment including approved respiratory protection. Incompatibility: Incompatible with alkaline materials. Respirator: An approved respirator suitable for protection Compatible with most pesticides. Do not physically mix concentrate directly with other herbicides or pesticide from dusts and mists of pesticides is adequate. Limitations concentrates; always dilute first. A compatibility test is of respirator use specified by the approved agency and the required before using with other products. manufacturer must be observed. Thermal decomposition: When heated Clothing: Employee must wear appropriate protective to decomposition, Methamidophos releases toxic fumes of (impervious) clothing and equipment to prevent repeated oxides of nitrogen, phosphorus, and sulphur. or prolonged skin contact with the substance. Gloves: Employee must wear appropriate synthetic protective gloves to prevent contact with this substance.

TOXICOLOGICAL INFORMATION

Eye protection: The use of full-face protection is Acute oral LD50: 20 to 55 mg/kg for rats. recommended. Acute dermal LD50: 130 mg/kg in rats. 118 mg/kg in Emergency eyewash: Where there is any possibility that rabbits. an employee’s eyes may be exposed to this substance; Acute inhalation (Active ingredient): the employer should provide an eye wash fountain or appropriate alternative within the immediate work area for LC50 (4 h) for rats 0.2 mg/. emergency use. Acute eye irritation: Slightly irritating to eyes. Acute skin irritation: 9. PHYSICAL AND CHEMICAL PROPERTIES Irritant. Dermal sensitization: Appearance: Yellowish liquid. Consider as if irritation may occur. Odour: Pungent odour. Reproductive, Teratogenic and Mutagenic Effects: Explosive properties: Not explosive. No information available. Corrosive properties: Corrosive to mild steel and copper Carcinogenicity: containing alloys. Possible carcinogen. pH: Not available. Vapour pressure: 2,3 x 10(-5) mbar at 20 OC. Relative density: 1.08 to 1.15 g/cm3 @ 20 oC.

ECOLOGICAL INFORMATION

Storage stability: Considered stable for a period of 2 years in normal air, warehouse and light conditions. Degradability: Most organophosphate pesticides Persistent foaming: Not available. degrade relatively rapidly in the environment. All Suspensibilty: Not available. organophosphate esters undergo hydrolysis in water; Dilution stability: Not available. generally the water-soluble products of hydrolysis are less Solubility in water: Soluble in water. toxic than the parent compound. Degradation is by Solubility in organic solvents: (All solubility figures in for hydrolysis with loss of the amino, S-methyl or O-methyl technical) groups. Mobility: Due to the rapid degradation of the substance, Class: 3 it’s leaching into deeper soil layers can be ruled out. Subsidiary risk: 6.1 Accumulation: Does not accumulate. Hazard Label: Flammable liquid & Toxic ECOTOXICOLOGY: Very toxic to birds, fish and bees. Packaging Group: II Birds: Methamidophos is very toxic to birds. Passenger Aircraft: 305 (max 1 L) Oral LD50: bobwhite quail: 8 to 11 mg/kg. Y305 (max 1 L) Mallard ducks: 29.5 mg/kg Cargo Aircraft: 307 (max 60 L) Fish:

EU Classification

Not available. Methamidophos is toxic to aquatic organisms. LC50 (96 hours): rainbow trout: 40 mg/ 15. REGULATORY INFORMATION Bees: Toxic to bees.

Hazard pictograms

F, T, N Earthworms:

Hazard statements

LC50: Eisenia foetida: 73 mg/kg dry soil R 10 Flammable Daphnia: R 24 Toxic in contact with skin. LC50: 48 hours: 0.27 mg/ R 28 Very toxic if swallowed. R 50 Very toxic to aquatic organisms. 13. DISPOSAL CONSIDERATION

Precautionary statements

S 1/2 Keep locked up and out of reach children. Pesticide disposal: Contaminated absorbents, used S36/37 Wear suitable protective clothing and containers, surplus product, etc., should be burnt at gloves. 1000oC in an incinerator, preferably designed for pesticide S45 In case of accident or if you feel unwell, disposal, or buried in designated landfill. Hydrolysis under seek medical advice immediately (show the alkaline conditions (e.g. sodium hydroxide) is a suitable label where possible). method to dispose of small quantities of the product. After S60 This material and its container must be hydrolysis, dilute and dispose of via the sewage system. disposed of as hazardous waste. Comply with local legislation applying to waste disposal. S 61 Avoid release to the environment. Refer to Package product wastes: Emptied containers retain special instructions. vapour and product residues. Observe all labelled Indication of danger: Flammable. Toxic. safeguards until container is cleaned, reconditioned, or Environmentally dangerous substance. destroyed. Combustible containers should be disposed of in pesticide incinerators or buried in an approved landfill. 16. PACKING AND LABELLING Non-combustible containers must be triple rinsed with water and then be punctured and transported to a facility Packed in 5, 10, 20 & 25 metal or fluorinated plastic for recycling or disposal in approved landfill site. Comply containers and labelled according to South African with any local legislation applying to disposal. regulations and guidelines. 14. TRANSPORT INFORMATION 17. OTHER INFORMATION All information and instructions provided in this Material