METHIDATHION 420 EC

SECTION 2: Hazards identification

eyelid(s) open. Seek medical attention immediately. Ingestion: Have victim rinse mouth thoroughly with water. Main Hazard: This compound inhibits cholinesterase Seek medical advice immediately. Do not induce enzyme activity in the nervous tissue. It is highly toxic. vomiting. Do not give saltwater or any other emetic. Contact with skin, inhalation of spray, or swallowing may Advice to physician: Atropine must be administrated as be fatal. early as possible and adequately enough to achieve Ingestion: Toxic by ingestion. If large amounts are atropinisation, as evidenced by dilation of the pupils, drying swallowed and aspiration occurs, chemical pneumonitis secretion, pulse rate of over 120/minute, and flushing skin. may develop. Small amounts of product aspirated into the To prevent gastrointestinal absorption in unconscious respiratory system during ingestion or vomiting, due to the persons who have swallowed this product, perform solvent in product, may cause mild to severe pulmonary stomach lavage using bicarbonate solution and activated injury. charcoal. In less severe cases begin with 2 mg atropine Inhalation: Toxic by inhalation. Irritating to respiratory intravenously for adults or 0.05 mg atropine/kg body system. weight intravenously for children under 12 years of age and repeat administration of the drug at 15 to 30 minute intervals. In severe cases inject as early as possible IV, from maximum distance. For massive fire, use unmanned atropine sulphate 2 to 4 mg/kg body weight (for adults) hose holder or monitor nozzles. Contain fire control (0,04 to 0,08 mg/kg body weight for children) and repeat at agents for later disposal. Use a recommended 2 mg for adults (0,04 mg/kg for children) every 3 to 10 extinguishing agent for the type of surrounding fire. Avoid minutes until adequately atropinised. A total atropine dose inhaling hazardous vapours. Keep upwind. of 20 to 80 mg in the first hour may be necessary, with Special Hazards: This product will emit toxic fumes when repeated drug administrations at 3 to 10 minute intervals. burned. Produce irritating or poisonous mists or other When signs of atropinisation appear, the dose and products of combustion. Combustion product is sulphur frequency of administration should be reduced to a dioxide. schedule that will maintain full atropinisation for at least 24 Personal protective equipment: Fire fighters and others hours. Overdosage with atropine is rarely serious, but that may be exposed should wear full protective underdosage may be fatal in poisoning with impervious clothing, including gloves and eye protection, organophosphorous compounds. and self-contained breathing apparatus. Contact with the In any severe progressive case of poisoning a fumes and vapours should be avoided by staying upwind. cholinesterase reactivator e.g. pralidoxine (2PAM), if Clean all clothing before re-use. Severely contaminated available, should be administered, preferably within 8h clothing cannot be adequately decontaminated, and must after intoxication. An average dose is 1 g for an adult (up be disposed as a hazardous waste. Shower with soap to 50 mg/kg for children), usually given half as a single and water after contact with this product. intramuscular or intravenous injection and the other half as an intravenous infusion with glucose and or saline. In 6. ACCIDENTAL RELEASE MEASURES (SPILLAGE) severe cases this treatment may be repeated in 1 to 2 hours, then at 10 to 12 hour intervals if needed, but not Personal precautions: Do not inhale fumes. Avoid beyond 24 hours, or 48 hours at the most. Pralidoxime contact with skin, eyes or clothes. Ventilate area of spill or should be administered very slowly. If respiration is leak, especially confined areas. For personal protection depressed during or after pralidoxime injection, pulmonary see Section 8. ventilation should be assisted mechanically. Toxogonin is Environmental precautions: Do not allow entering a more recent cholinesterase reactivator. It can be drains or watercourses. Spillage or uncontrolled administrated instead of 2PAM at a dose of 250 mg discharges into water courses (or public waters) to be intramusculary for adults (4 to 8 mg/kg for children) and, if reported immediately to the Police and to the Department necessary, repeated after 1 to 2 hours. of Water/Environmental Affairs. Diazepam should be included in the therapy of severe Occupational spill: Earth all equipment used when cases and whenever convulsions appear. Doses of 5 to handling the product. Do not touch or walk through spilled 10 mg for adults (2 to 5 mg for children) can be material. Stop leak if possible without risk. Avoid runoff of administered intravenously or subcutaneously or per product into sewers, water systems, basements or rectum, and repeated as required. confined areas as it may cause fire/explosion. Vapour- NB: Because of their respiratory-depressant effects, suppressing foam could be used to reduce vapours. morphine and similar drugs are contraindicated for patients Thoroughly wash body areas, which come into contact poisoned with organophosporous compounds. Avoid with the product. aminoglycosides and succinylcholine, which have a For spills: Use clean, non-sparking tools to collect blocking effect on the neuromuscular junction. absorbed material. Soak up with absorptive material such Phenothiazines, reserpine and theophylline are as damp earth or sand or other suitable non-combustible contraindicated in organophosphorous poisoning. absorbent material. Place the material into a clean, dry container and cover for subsequent disposal. In situations 5. FIRE FIGHTING MEASURES where product comes in contact with water, contain contaminated water for later disposal. Prevent material Flammable properties Flammable – Flash point 40 OC. from spreading by damming in with absorptive material Extinguishing agents: Extinguish fires with carbon Do not flush spilled material into drains. Keep spectators dioxide, dry powder, or alcohol-resistant foam. Water away and upwind. spray as a fog can be used for cooling of unaffected stock, To decontaminate spill area, tools and equipment, wash but avoid water coming in contact with the product. with a suitable solution (i.e. organic solvent, detergent Contain water used for fire fighting for later disposal. bleach or caustic). Add the solution to the drums already Avoid the accumulation of polluted run-off from the site. collected. Label drums with its content and dispose it in Firefighting: Remove spectators from surrounding area. accordance with local regulations. Remove container from fire area if possible without risk. Open burning or dumping of this material is prohibited. Eliminate all ignition sources in immediate area. Fight fire Do not get water inside containers. 7. HANDLING AND STORAGE REQUIREMENTS the employer should provide an eye wash fountain or appropriate alternative within the immediate work area for