GENOATE 400 EC

SECTION 2: Hazards identification

Inhalation: Remove source of contamination or move victim to fresh air. Keep affected person warm and at rest. Toxicity class: WHO Ib; EPA II Supply oxygen if necessary. Treat symptomatically and ADI: 0.002 mg/kg supportively. Seek medical advice immediately. NOEL: 5.0 mg/kg (rats) Skin contact: Remove contaminated clothing, shoes and intramusculary for adults (4 to 8 mg/kg for children) and, if leather goods. Gently wipe of excess chemical. Wash necessary, repeated after 1 to 2 hours. skin gently and thoroughly with water and non-abrasive Diazepam should be included in the therapy of severe soap. Seek medical advice if necessary. Persons who cases and whenever convulsions appear. Doses of 5 to become sensitised may require specialised medical 10 mg for adults (2 to 5 mg for children) can be management with anti-inflammatory agents. administered intravenously or subcutaneously or per Eye contact: Immediately flush eyes with gently flowing rectum, and repeated as required. cold water or saline solution for 20 minutes, holding the IMPORTANT eyelid(s) open. Seek medical attention immediately. Because of their respiratory-depressant effects, morphine Ingestion: Have victim rinse mouth thoroughly with water. and similar drugs are contraindicated for patients poisoned Do not induce vomiting, due to the aromatic solvent. Seek with organophosporous compounds. Avoid medical advice immediately. aminoglycosides and succinylcholine, which have a Advice to physician: Atropine must be administrated as blocking effect on the neuromuscular junction. early as possible and could save lives, if given in time and Phenothiazines, reserpine and theophylline are in an adequate dosage. Patients with organophosphate contraindicated in organophosphorous poisoning. poisoning require amounts of atropine far in excess of doses usually employed in medical practice. The 5. FIRE FIGHTING MEASURES therapeutic objective is to achieve atropinisation, as evidenced by dilation of the pupils, drying secretion, pulse Extinguishing agents: Extinguish small fires with carbon rate of over 120 per minute and flushing skin. To prevent dioxide, dry powder, or alcohol-resistant foam. Water gastrointestinal absorption in unconscious that have spray can be used for cooling of unaffected stock, but swallowed this product, perform stomach lavage using avoid water coming in contact with the product. Contain bicarbonate solution and activated charcoal. water used for fire-fighting for later disposal. In less severe cases begin with 2 mg atropine Avoid the accumulation of polluted run-off from the site. intravenously for adults or 0.05 mg atropine/kg body Firefighting: Remove spectators from surrounding area. weight intravenously for children under 12 years of age Remove container from fire area if possible. Fight fire from and repeat administration of the drug at 15 to 30 minutes maximum distance. For massive fire, use unmanned hose intervals. holder or monitor nozzles. Contain fire control agents for In severe cases a total atropine dose of 20 to 80 mg in the later disposal. Use a recommended extinguishing agent first hour may be necessary, with repeated drug for the type of surrounding fire. Water can be used to cool administrations at 3 to 10 minute intervals. When signs of unaffected containers but must be contained for later atropinisation appear, the dose and frequency of disposal. Avoid inhaling hazardous vapours. Keep administration should be reduced to a schedule that will upwind. maintain full atropinisation for at least 24 hours. Over Special Hazards: Fire may produce irritating or dosage with atropine is rarely serious, but under dosage poisonous mists (hydrogen sulfide, carbon oxides and may be fatal in poisoning with organophosphorous sulfur oxides) or other products of combustion. compounds. Personal protective equipment: Fire-fighters and others In any severe progressive case of poisoning a that may be exposed should wear full protective clothing cholinesterase reactivator e.g. pralidoxine (2PAM), if and self-contained breathing apparatus. available, should be administered, preferably within 8 hours after intoxication. An average dose is 1 g for an 6. ACCIDENTAL RELEASE MEASURES (SPILLAGE) adult (up to 50 mg/kg for children), usually given half as a single intramuscular or intravenous injection and the other Personal precautions: Do not inhale fumes. Ventilate half as an intravenous infusion with glucose and or saline. area of spill or leak, especially confined areas. Avoid In severe cases this treatment may be repeated in 1 to 2 contact with skin, eyes or clothes. For personal protection hours, then at 10 to 12 hour intervals if needed, but not see Section 8. beyond 24 hours, or 48 hours at the most. Pralidoxime Environmental precautions: Do not allow entering should be administered very slowly. If respiration is drains or watercourses. When the product contaminates depressed during or after pralidoxime injection, pulmonary public waters, inform appropriate authorities immediately in ventilation should be assisted mechanically. accordance with local regulations. Toxogonin is a more recent cholinesterase reactivator. It Occupational spill: For small spills, soak up sand or can be administrated instead of 2PAM at a dose of 250 mg suitable non-combustible absorbent material, place into containers for subsequent disposal. Thoroughly wash Clothing: Employee must wear appropriate protective body areas, which come into contact with the product. (impervious) clothing and equipment to prevent skin Avoid runoff to sewer as it may cause fire/explosion. Do contact with the substance. not allow the product to come in contact with water Gloves: Employee must wear appropriate chemical systems. resistant protective gloves to prevent contact with this For large spills contact the manufacturer. Contain liquid substance. far ahead of spill. Contain spillage and contaminated Eye protection: Employee must wear splash-proof safety water for subsequent disposal. Do not flush spilled goggles and face-shield to prevent contact with this material into drains. Keep spectators away and upwind. substance. Emergency eye wash: Where there is any possibility that 7. HANDLING AND STORAGE REQUIREMENTS an employee’s eyes may be exposed to this substance; the employer should provide an eye wash fountain or