CHLORPYRIFOS 480 EC

SECTION 2: Hazards identification

First aid should include, if necessary, mouth-to-nose respiration, cardiac massage and avoidance of injury in Toxicity class: patients with trauma. WHO II; EPA II Inhalation: Remove source of contamination or move victim to fresh should be administered very slowly. If respiration is air. Keep affected person warm and at rest. Supply depressed during or after pralidoxime injection, pulmonary oxygen if necessary. Treat symptomatically and ventilation should be assisted mechanically. supportively. Seek medical advice immediately. Toxogonin is a more recent cholinesterase reactivator. It Skin contact: can be administrated instead of 2PAM at a dose of 250mg Remove contaminated clothing, shoes and leather goods. intramusculary for adults (4 to 8 mg/kg for children) and, if Gently wipe of excess chemical. Wash skin gently and necessary, repeated after 1 to 2 hours. thoroughly with water and non-abrasive soap. Seek Diazepam should be included in the therapy of severe medical advice if necessary. Persons who become cases and whenever convulsions appear. Doses of 5 to sensitised may require specialised medical management 10 mg for adults (2 to 5 mg for children) can be with anti-inflammatory agents. administered intravenously or subcutaneously or per Eye contact: rectum, and repeated as required. Immediately flush eyes with gently flowing cold water or NOTE saline solution for 20 minutes, holding the eyelid(s) open. Because of their respiratory-depressant effects, morphine Seek medical attention immediately. and similar drugs are contraindicated for patients poisoned Ingestion: with organophosporous compounds. Avoid Have victim rinse mouth thoroughly with water. Do not aminoglycosides and succinylcholine, which have a induce vomiting, due to the aromatic solvent. Seek blocking effect on the neuromuscular junction. medical advice immediately. Phenothiazines, reserpine and theophylline are Advice to physician: contraindicated in organophosphorous poisoning. Atropine must be administrated as early as possible and could save lives, if given in time and in an adequate 5. FIRE FIGHTING MEASURES dosage. Patients with organophosphate poisoning require amounts of atropine far in excess of doses usually Fire and explosion hazard: employed in medical practice. The therapeutic objective is Product is highly Flammable and explosive due to the to achieve atropinisation, as evidenced by dilation of the solvent used. pupils, drying secretion, pulse rate of over 120 per minute, Extinguishing agents: and flushing skin. To prevent gastrointestinal absorption in Carbon dioxide, dry powder, or alcohol-resistant foam can unconscious that have swallowed this product, perform be used to extinguish small fires. Water spray can be used stomach lavage using bicarbonate solution and activated for cooling of unaffected stock, but avoid water coming in charcoal. contact with the product. Contain water used for fire In less severe cases begin with 2 mg atropine fighting for later disposal. Avoid the accumulation of intravenously for adults or 0.05 mg atropine/kg body polluted run-off from the site. weight intravenously for children under 12 years of age Fire fighting: and repeat administration of the drug at 15 to 30 minute Remove spectators from surrounding area. Remove intervals. container from fire area if possible. Fight fire from In severe cases a total atropine dose of 20 to 80 mg in the maximum distance. For massive fire, use unmanned hose first hour may be necessary, with repeated drug holder or monitor nozzles. Contain fire control agents for administrations at 3 to 10 minute intervals. When signs of later disposal. Use a recommended extinguishing agent atropinisation appear, the dose and frequency of for the type of surrounding fire. Water can be used to cool administration should be reduced to a schedule that will unaffected containers but must be contained for later maintain full atropinisation for at least 24 hours. disposal. Avoid inhaling hazardous vapours. Keep Overdosage with atropine is rarely serious, but upwind. underdosage may be fatal in poisoning with Personal protective equipment: organophosphorous compounds. Fire may produce irritating or poisonous vapours (toxic In any severe progressive case of poisoning a fumes of hydrogen cyanide, chlorine, and oxides of cholinesterase reactivator e.g. pralidoxine (2PAM), if nitrogen and carbon), mists or other products of available, should be administered, preferably within 8 combustion. Fire fighters and others that may be exposed hours after intoxication. An average dose is 1 g for an should wear full protective clothing and self-contained adult (up to 50 mg/kg for children), usually given half as a breathing apparatus. single intramuscular or intravenous injection and the other half as an intravenous infusion with glucose and or saline. 6. ACCIDENTAL RELEASE MEASURES (SPILLAGE) In severe cases this treatment may be repeated in 1 to 2 hours, then at 10 to 12 hour intervals if needed, but not Personal precautions: beyond 24 hours, or 48 hours at the most. Pralidoxime Do not inhale fumes. Ventilate area of spill or leak, If engineering controls and work practices are not effective especially confined areas. Avoid contact with skin, eyes or in controlling exposure to this material, then wear suitable clothes. For personal protection see Section 8. personal equipment including approved respiratory