HD Diesel Antifreeze

Hazard statements (CLP)

H300

Code

Statements

H300

Fatal if swallowed

SECTION 2: Hazards identification

Emergency Overview Harmful Or Fatal If Swallowed. Solution is poisonous to both humans and animals. Excessive exposure has been shown to cause birth defects in laboratory testing. Potential Health Effects (See Section 11 for toxicological data) Eye : May cause slight transient (temporary) eye irritation. Vapours may irritate eyes. Corneal injury is unlikely. Skin : Essentially non-irritating to skin. Repeated skin exposure may result in absorption of harmful amounts. Massive contact with damaged skin or of material sufficiently hot to burn skin may result in absorption of potentially lethal amounts. Ingestion : Single dose oral toxicity is considered to be moderate. Excessive exposure may cause central nervous system effects, cardiopulmonary effects (meta- bolic acidosis), and kidney failure. The lethal dose in humans is estimated to be 100ml (3 ounces). Small amounts swallowed incidental to normal han- dling operations are not likely to cause injury; however, swallowing amounts larger than that may cause serious injury, even death. Inhalation : At room temperatures, vapours are minimal due to low vapour pressure. If material is heated or mist is produced, concentrations may be attained that are sufficient to cause irritation and other effects. Systemic Effects : Excessive exposure may cause irritation to upper respiratory tract. Obser- vations in animals include formation of bladder stones after repeated oral doses of diethylene glycol. Observations in animals include kidney and liver effects and deposition of calcium salts in various tissues after long-term dietary intake of ethylene glycol.

Cancer information

Based on data from long-term animal studies, diethylene glycol is not believed to pose A carcinogenic risk to man. Ethylene glycol did not cause cancer in long-term animal studies. Teratology : Based on animal studies, ingestion of very large amounts of ethylene glycol appears to be the major and possibly only route of exposure to produce birth defects. Exposures by inhalation (tested nose-only in animals to prevent ingestion) or skin contact, the primary routes of occupational exposure, had minimal or essentially no effect on the fetus. Birth defects are unlikely from exposure to minor component diethylene glycol. Exposures having no ad- verse effects on the mother should have no effect on the fetus. Reproductive Effects : Ingestion of large amounts of ethylene glycol has been shown to interfere with reproduction in animals. Specifically, growth retardation and decreased litter size in rats and mice and mating frequency in mice were observed. Re- productive effects are unlikely from exposure to minor component diethylene glycol.