S-1812 35 WP

SECTION 2: Hazards identification

EMERGENCY OVERVIEW CAUTION: - FOR RESEARCH AND DEVELOPMENT PURPOSES ONLY - TO BE USED ONLY UNDER THE DIRECT SUPERVISION OF A TECHNICALLY QUALIFIED INDIVIDUAL - HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGHT SKIN - MAY CAUSE SKIN, EYE AND RESPIRATORY IRRITATION - AVOID CONTACT WITH SKIN, EYES, OR CLOTHING - AVOID BREATHING DUST OR SPRAY MIST - KEEP OUT OF REACH OF CHILDREN EMERGENCY TELEPHONE #: (800) 892-0099 NDA – No Data Available NA – Not Applicable MSDS Number: 0196 Revision Number: 1 Revision Date: 03/13/2002

Potential health effects

Acute Toxicity (Primary Routes of Exposure) Signs and Symptoms of Systemic Effects: This product is minimally toxic following a single oral, dermal or inhalation exposure. Eye: This product can cause brief and/or minor eye irritation. The expected adverse resulting from an exposure may include redness and possible swelling Skin: This product can cause brief and/or minor irritation. The expected adverse health effects resulting from an exposure may include redness and possibly some minor swelling. This product is not expected to cause allergic skin reactions. This product is minimally toxic when absorbed through the skin. Ingestion: This product is minimally toxic when ingested. Inhalation: This product is minimally toxic when inhaled. Exposure to high concentrations of dust may result in respiratory irritation. Signs and symptoms may include, but not be limited to, nasal discharge, sore throat, coughing and difficulty in breathing. Chronic Toxicity (Including Cancer): Target organs following repeated exposures at high doses of pyridalyl technical in animal studies include the liver, kidney, ovary, lung, adrenal, heart, blood cells, heart and thymus. Treatment-related effects observed in the 2-year rat study at doses of 500 ppm or higher included increased motor activity, decreased body weight, body weight gain, food consumption and food efficiency, and changes in spleen color. No evidence of carcinogenicity was observed in rats. In an 18-month study in mice, decreased body weight, body weight gain and food consumption, and increased liver and kidney weights were observed at doses of 1000 ppm or higher. While a slight increase in lung tumors was observed in females in the 2500 ppm group, the incidence was within historical control range and there were no indications of carcinogenic activity. This product contains a type of amorphous silica. Inhalation of the dust may produce some or all of the following signs and symptoms: coughing, bronchial irritation, chest discomfort and shortness of breath. Repeated exposure to amorphous silica dust has caused impaired pulmonary function and morphological lung changes in monkeys. Under identical exposure conditions, rats and guinea pigs were unaffected by amorphous silica dust. Teratology (Birth Defects) Information: Pyridalyl technical did not produce developmental effects in rats. In a study with rabbits, developmental effects were observed only at doses which produced maternal toxicity. Reproduction Information: Pyridalyl technical was tested in a 2-generation rat reproduction study. Effects on the reproduction and offspring were observed only at doses which produced general toxicity in the adults. Potentially Aggravated Conditions: Individuals with preexisting diseases of the liver, kidney or endocrine glands may have increased susceptibility to the toxicity of excessive exposures. For complete discussion of the toxicology data from which this evaluation was made, refer to Section 11. For Regulatory Information, refer to Section 15. EMERGENCY TELEPHONE #: (800) 892-0099 NDA – No Data Available NA – Not Applicable MSDS Number: 0196 Revision Number: 1 Revision Date: 03/13/2002