DISTANCE Insect Growth Regulator

SECTION 2: Hazards identification

EMERGENCY OVERVIEW CAUTION: - CAUSES SKIN AND EYE IRRITATION - HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH THE SKIN -

Aspiration hazard

DO NOT INDUCE VOMITING - AVOID BREATHING VAPOR OR SPRAY MIST - DO NOT GET IN EYES, ON SKIN OR ON CLOTHING - KEEP OUT OF REACH OF CHILDREN EMERGENCY TELEPHONE #: (800) 892-0099 NDA – No Data Available NA – Not Applicable MSDS Number: 0182 Revision Number: 6 Revision Date: 02/21/2003

Potential health effects

Acute Toxicity (Primary Routes of Exposure) Signs and Symptoms of Systemic Effects: The acute toxicity of this product is relatively low; transient, minimal signs of toxicity were observed in rats at high oral doses. This product does contain a solvent mixture. Solvents when inhaled can cause nasal and respiratory irritation and central nervous system effects including dizziness, weakness, fatigue, nausea, headache and possibly unconsciousness and even death. Ingestion of solvents can cause gastrointestinal irritation, nausea, vomiting and diarrhea. Aspiration of low viscosity solvents can cause chemical pneumonitis that can be fatal. Eye: This product is expected to cause brief and/or minor eye irritation. The expected adverse effects resulting from an exposure may include redness and possibly some minor swelling. Skin: This product has been shown to cause prolonged and/or significant skin irritation. The expected adverse health effects resulting from an exposure may include redness, swelling and pain for an extended period of time. This product is not expected to cause allergic skin reactions. This product has been shown to be slightly toxic when absorbed through the skin. The expected adverse systemic health effects resulting from an exposure are described above. Ingestion: Ingestion of this product may cause gastrointestinal irritation, nausea, vomiting and diarrhea. Because of the low viscosity of this product, it can directly enter the lungs if it is swallowed (this is called aspiration). This can occur during the act of swallowing or when vomiting. Once in the lungs, the substance is very difficult to remove and can cause severe injury to the lungs and death. This product has been shown to be slightly toxic when ingested. The expected adverse systemic health effects resulting from an exposure are described above. Inhalation: Exposure to very high concentrations may result in respiratory irritation. Signs and symptoms may include nasal discharge, sore throat, coughing and difficulty in breathing. This product has been shown to be minimally toxic when inhaled. The expected adverse systemic health effects are described above. Chronic Toxicity (Including Cancer): Studies with Pyriproxyfen Technical indicated that repeated high exposures produced changes in the liver, kidney and red blood cells but did not produce cancer in test animals. This product contains a solvent mixture. Reports have associated repeated and prolonged occupational overexposures to solvents with permanent brain and nervous system damage. Symptoms reported include fatigue, concentration difficulties, anxiety, depression, rapid mood swings and short term memory loss. Since many other diseases cause some or all of these conditions, a doctor should be consulted if any appear. This product contains naphthalene which has been listed by the International Agency for Research on Cancer (IARC) as possibly carcinogenic to humans (Group 2B). Overall, this product is not expected to be a chronic hazard when used according to label directions. EMERGENCY TELEPHONE #: (800) 892-0099 NDA – No Data Available NA – Not Applicable MSDS Number: 0182 Revision Number: 6 Revision Date: 02/21/2003 Teratology (Birth Defects) Information: No developmental toxicity was produced in animals exposed to Pyriproxyfen Technical, even at doses that were toxic to the pregnant animal. This product is not expected to be a developmental hazard when used according to label directions. Reproduction Information: Pyriproxyfen Technical did not produce reproductive toxicity in animal studies. This product is not expected to be a reproductive hazard when used according to label directions. Potentially Aggravated Conditions: Individuals with preexisting diseases of the liver, kidney, red blood cell or central nervous system may have increased susceptibility to the toxicity of excessive exposures. For complete discussion of the toxicology data from which this evaluation was made, refer to Section 11. For Regulatory Information, refer to Section 15.