Overture 35 WP Insecticide

SECTION 2: Hazards identification

EMERGENCY OVERVIEW. CAUTION • May cause moderate eye irritation • Avoid contact with eyes or clothing • May cause brief and/or minor skin irritation • Keep out of reach of children

Potential health effects

Acute Toxicity (Primary Routes of Exposure) Signs and Symptoms of Systemic Effects: This product produced minimal toxicity in tests with animals even at very high doses. Acute Eye Contact: This product can cause brief and/or minor eye irritation. The expected adverse health effects resulting from an exposure may include redness and possible swelling. Acute Skin Contact: This product can cause brief and/or minor irritation. The expected adverse health effects resulting from an exposure may include redness and possibly some minor swelling. This product is minimally toxic when absorbed through the skin. This product is not expected to cause allergic skin reactions. Acute Ingestion: This product is minimally toxic when ingested. Acute Inhalation: This product is minimally toxic when inhaled. Exposure to high concentrations of dust may result in respiratory irritation. Signs and symptoms may include, but not be limited to, nasal discharge, sore throat, coughing and difficulty in breathing. Chronic Toxicity (including cancer): Target organs following repeated exposure at high doses of pyridalyl technical in animal studies include the liver, kidney, ovary, lung, adrenal, heart, blood cells and thymus. Treatment-related effects observed in the 2-year rat study at doses of 500 ppm or higher included increased motor activity, decreased body weight, body weight gain, food consumption and food efficiency, and changes in spleen color. No evidence of carcinogenicity was observed in rats. In an 18-month study in mice, decreased body weight, body weight gain and food consumption, and increased liver and kidney weights were observed at doses of 1000 ppm or higher. While a slight increase in lung tumors was observed in females in the 2500 ppm group, the incidence was within the historical control range and there were no indications of carcinogenic activity. This product contains a type of amorphous silica. Inhalation of the dust may produce some or all of the following signs and symptoms: coughing, bronchial irritation, chest discomfort and shortness of breath. Repeated exposure to amorphous silica dust has caused impaired pulmonary function and morphological lung changes in monkeys. Under identical exposure conditions, rats and guinea pigs were unaffected by amorphous silica dust. Developmental Toxicity (birth defects): Pyridalyl technical did not produce developmental effects in rats. In a study with rabbits, developmental effects were observed only at doses which produced maternal toxicity. Reproductive Toxicity: Pyridalyl technical was tested in a 2-generation rat reproduction study. Effects on reproduction and the offspring were observed only at doses which produced general toxicity in the adults. Potentially Aggravated Medical Conditions: Individuals with preexisting diseases of the liver, kidney or endocrine glands may have increased susceptibility to the toxicity of excessive exposures. For complete discussion of the toxicology data from which this evaluation was made, refer to Section 11. For Regulatory Information, refer to Section 15.