CARBOFURAN 100 GR

SECTION 2: Hazards identification

Localised sweating and fasciculation may occur at the site of contact. If sufficient amounts are absorbed through the Toxicity class: WHO Ib skin, other effects of cholinesterase inhibition may occur Main hazard: Carbofuran is a carbamate compound as described in acute inhalation. Symptoms may be which inhibits cholinesterase. It is of very high toxicity. delayed for 2 to 3 hours, usually no more than 8 hours. Contact with skin, inhalation of dust or granules, or Chronic exposure: Repeated or prolonged exposure may swallowing may be fatal. cause effects as described in acute exposure. Toxic to fish. First aid: Remove contaminated clothing immediately. Wash contaminated areas with soap and water followed by alcohol. Emergency personnel should wear gloves Improve tissue oxygenation as much as possible before and avoid contamination. Treat respiratory difficulty with administrating atropine to minimise the risk of ventricular mechanical artificial respiration. Get medical attention fibrillation. Administer atropine sulphate intravenously, or immediately. intramuscularly if iv injection is not possible. In Eye contact Carbamate Cholinesterase inhibitor moderately severe poisoning administer atropine Acute exposure: Direct contact may cause pain, sulphate, 0.4 to 2.0 mg repeated every 15 minutes, until hyperaemia, lacrimation, twitching of the eyelids, miosis, atropinization is achieved (tachycardia, flushing, dry and ciliary muscle spasm with loss of accommodation, mouth, mydriasis). Maintain atropinization by repeated blurred or dimmed vision and browache. Sometimes doses for 2 to 12 hours, or longer, depending on the mydriasis may occur instead of miosis. With sufficient severity of poisoning. The appearance of rales in the lung exposure, other symptoms of cholinesterase inhibition bases, miosis, salivation, nausea, bradycardia, are all may occur as described in acute inhalation. indications of inadequate atropinization. Severely Chronic exposure: Prolonged exposure may cause poisoned individuals may exhibit remarkable tolerance to effects as described in acute exposure. Some atropine. Two or more times the dosages suggested compounds have caused toxic effects on the crystalline above may be needed. Persons not poisoned or only lens, conjunctival thickening and obstruction of slightly poisoned, however, may develop signs of atropine nasolacrimal canals when used as miotic eye drops. toxicity from such large dosages: fever, muscle First aid: Irrigate eyes with water or saline solution. If fibrillations, and delirium are main signs of atropine symptoms of poisoning occur, treat respiratory difficulty toxicity. If these signs appear while the patient is fully with mechanical artificial respiration and oxygen. atropinized, atropine administration should be Observe patient for at least 24 to 36 hours. Get medical discontinued, at least temporarily. Observe treated attention immediately. Oxygen should be administered by patients closely at least 24 hours to ensure that symptoms qualified medical personnel. (possibly pulmonary oedema) do not recur as Ingestion Carbamate Cholinesterase inhibitor atropinization wears off. In very severe poisonings, Acute exposure: When ingested, the first effects may be metabolic disposition of toxicant may require several nausea, vomiting, anorexia, abdominal cramps, and hours or days during which atropinization must be diarrhoea. With absorption from the gastrointestinal tract, maintained. Markedly lower levels of urinary metabolites the other effects of cholinesterase inhibition as described indicate that atropine dosage can be tapered off. As the in acute inhalation may occur. Symptoms may begin dosage is reduced, check the lung bases frequently for within minutes or be delayed several hours. rales. If rales are heard or other symptoms return, re- Chronic exposure: Repeated ingestion may cause effects establish atropinization promptly. as described in acute exposure. First aid: If person is alert and respiration is not 5. FIRE FIGHTING MEASURES depressed, give syrup of Ipecac followed by water (if vomiting occurs, keep head below hips to prevent Fire and explosion hazard: Not flammable. Toxic dust aspiration). If consciousness level declines or vomiting and irritating fumes may be produced during fires. has not occurred in 15 minutes empty stomach by gastric Extinguishing agents: Extinguish small fires with lavage with the aid of cuffed endotracheal tube using carbon dioxide, dry chemical, water spray or standard isotonic saline or 5 % sodium bicarbonate follow with foam. For larger fires, use dry chemical, "alcohol" foam, activated charcoal. Establish and maintain airway. Treat Halon, or carbon dioxide to fight fire. respiratory difficulty with artificial respiration and oxygen. Personal protective equipment: Fire may produce Do not give morphine, aminophylline, irritating or poisonous vapours (toxic oxides of nitrogen), phenothiazines, reserpine, furosemide, or ethacrynic mists or other products of combustion. Fire-fighters and acid. Drugs like 2 PAM are not effective in poisoning others that may be exposed should wear full protective with Carbofuran AND SHOULD NOT BE USED. clothing and self-contained breathing apparatus. Treat symptomatically and supportively. Administration of oxygen and gastric lavage must be performed by qualified 6. ACCIDENTAL RELEASE MEASURES (SPILLAGE) medical personnel. Get medical attention immediately. Advice to physician: