General Information
Revision date
2019-10-30
Product name
Methotrexate
Product Synonyms
Amethopterin * 4-Amino-10-methylfolic acid
Chemical name
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl) methyl]methylamino]benzoyl]-
CAS No.
59-05-2
1.2.1 Relevant identified uses
Specified quality tests and assay use only
Manufacturer Name
U. S. Pharmacopeia
Emergency telephone
1-800-424-9300, +1 703-527-3887
Icons in SDS
Company Information
company name
U. S. Pharmacopeia
e-mail address of the competent person responsible for the Safety Data Sheet
RSTECH@usp.org
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H301, H319, H341, H351, H360, H372
Hazard statements
Code
Statements
H301
Toxic if swallowed
Section 2
SECTION 2: Hazards identification
Physical hazards
Not classified
Health hazards
Acute toxicity, oral Category 3 Serious eye damage/eye irritation Category 2A Germ cell mutagenicity Category 2 Carcinogenicity Category 2 Reproductive toxicity Category 1 Specific target organ toxicity, repeated Category 1 (bone marrow) exposure
Environmental hazards
Not classified
Signal word
Danger
Hazard statements
Toxic if swallowed. Causes serious eye irritation. Suspected of causing genetic defects. Suspected of causing cancer. May damage fertility or the unborn child. Causes damage to organs (bone marrow) through prolonged or repeated exposure.
Prevention
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapors/spray. Wash thoroughly after handling. Wear protective gloves/protective clothing/eye protection/face protection.
Response
If swallowed Immediately call a poison center/doctor. Rinse mouth. If in eyes Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists Get medical advice/attention. If exposed or concerned Get medical advice/attention.
Storage
Store locked up.
Disposal
Dispose of contents/container in accordance with local/regional/national/international regulations. Hazard(s) not otherwise None known. classified (HNOC)
Additional information
Potent pharmacologically active material.
2.1 Classification of the substance or mixture
Not classified. Health hazards Acute toxicity, oral Category 3 Serious eye damage/eye irritation Category 2A Germ cell mutagenicity Category 2 Carcinogenicity Category 2 Reproductive toxicity Category 1 Specific target organ toxicity, repeated Category 1 (bone marrow) exposure Environmental hazards Not classified. OSHA defined hazards Not classified.
