Sealate (T70-10)

SECTION 2: Hazards identification

WARNING!

Potential health effects

EYES: Although no appropriate human or animal health effects data are known to exist, this material is expected to cause slight eye irritation. May cause minor eye irritation. Symptoms may include excessive tearing, blinking and redness. SKIN ABSORPTION: Although no appropriate human or animal health effects data are known to exist, this material is no expected to be a health hazard by skin absorption. SKIN IRRITATION: Although no appropriate human or animal health effects data are known to exist, this material is expected to be a slight skin irritant. May cause minor skin irritation with symptoms including a slight localized redness or rash and swelling. Although no appropriate human or animal health effects data is known to exist, this material may cause an allergic skin reaction (sensitization) in susceptible individuals upon repeated exposure. INGESTION: Although no appropriate human or animal health effects data are known to exist, this material is expected to be a slight ingestion hazard. INHALATION: No significant signs or symptoms indicative of any adverse health hazard are expected to occur at standard conditions due to the low volatility of this material. However, aerosols, or vapors which may be generated at elevated processing temperatures, may cause respiratory tract irritation. Symptoms of irritation may include coughing, mucous production and shortness of breath. May also have potential to cause headaches, nausea and dizziness.

Potential chronic health

INFORMATION No chronic health effects information is available for this product. However, this product contains trace amounts of 1,3-butadiene which has been classified as probably carcinogenic to humans by the International Agency for Research on Cancer (IARC). In

Health hazards

if this product is used as supplied at room temperature; however, vapors generated at elevated processing temperatures may contain very small concentrations of 1,3-butadiene. Industrial hygiene monitoring should be performed to rule out exposure to this substance, and appropriate respiratory protection should be worn during these conditions. This material also contains trace amounts of 4-vinylcyclohexene (VCH). High concentrations of VCH (271-677 part per million) have caused eye and nose irritation, headaches, white blood cell reduction, and impaired carbohydrate metabolism in some workers. Animal tests have shown white blood cell reduction and effects in blood circulation upon repeated inhalation exposures, and kidney toxicity and ovarian effects at an oral dose (repeated exposure) that produced many animal deaths. The National Toxicology Program (NTP) conducted a two year animal study on the oral effects of VCH which resulted in numerous animal deaths and an (continued) increase in ovarian tumors in female mice. It is believer that mice have an increase sensitivity to VCH-induced ovarian effects as demonstrated by their ability to produce a significantly higher rate of an ovotoxic metabolite. IARC lists VCH as possibly carcinogenic to humans. The American Conference of Governmental Industrial Hygienists (ACGIH) classifies VCH as an animal carcinogen, causing cancer in test animals as relatively high doses, and by routes or mechanisms not considered relevant to worker exposure (i.e., ingestion is not a primary route of exposure for workers in an industrial setting). The ACGIH does list an exposure limit (TLV-TWA) of 0.1 ppm for VCH. Vapors generated at elevated processing temperatures may contain concentrations of VCH near the ACGIH TLV. VCH produced no genetic changes in tests using bacterial cells.