Thermo

Signal word

» Danger

Hazard statements

+ May damage the unborn child

Prevention

. Obtain special instructions before use, Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required.

Response

IF exposed or concemed: Get medical attention

Storage

+ Store locked up

Disposal

» Dispose of contents and container in accordance with all local. regional, national and international regulations.

2.3 Other hazards

+ None known P2014 No DrenOUS 4 Veracn ot wig Mixture Other means of » Not available. identification CAS numberother identifiers CAS number » Not applicable Ingredient name “hn CAS number imidazole 01-1 268-32-4 Any concentration shown as a range is to protect confidentiality or is due to batch variation There are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. Occupational exposure limits, if available, are listed in Section 8. Section 4. First aid measures Eye contact » Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Get medical attention if irritation accurs. Inhalation « Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration oF oxygen by trained personnel. It may be dangerous to the person providing aid ta give mouth-to-mouth resuscitation. Get medical attention. If unconscious, place in recovery position and get medical attention immediately. Maintain an open ainway Loosen tight clothing such as a collar, tie, belt or waistband Skin contact ; Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Wash contaminated clothing thoroughly with water before removing it, or wear gloves Continue to rinse for at least 10 minutes, Get medical attention. Wash clathing before reuse. Clean shoes thoroughly before reuse. Ingestion ; Wash out mouth with water, Remove dentures if any. Remove victim ta fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious. give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do nat induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Gel medical attention. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clathing such as a collar, tie, belt or waistband Most important symptomsieffects, acute and delayed

Potential Acute Health Effects

Eye contact No known significant effects or critical hazards. Inhalation No known significant effects or critical hazards. Skin contact No known significant effects or critical hazards. Ingestion No known significant effects or critical hazards. Ovor-expesure signs:symptoms Eye contact No specific data Inhalation » Adverse symptoms may include the folowing reduced fetal weight increase in fetal deaths skeletal malformations Skin contact » Adverse symptoms may include the following reduced fetal weight increase in fetal deaths skeletal malformations FABANE f us vatiatiogs, Waste 2G Autivaities and Recombinant Proteins Section 4. First aid measures Ingestion » Adverse symptoms may include the following reduced fetal weight increase in fetal deaths skeletal malformations ndication of immediate medical attention and special treatment necdad, if necessary Notes to physician + Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. Specific treatments No specific treatment Protection of first-aiders —; No action shall be taken involving any personal risk or without suitable training. If itis suspected that fumes are stil present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation, Wash contaminated clathing thoroughly with water before removing it, or wear gloves See toxicological information (Section 11} Section 5. Fire-fighting measures Extinguishing media Suitable extinguishing » Use an extinguishing agent suitable for the surrounding fire. media Unsuitable extinguishing — None known media Specific hazards arising » Ina fire or if heated. a pressure increase will ocour and the container may burst. from the chemical Hazardous thermal No specific data decomposition products Special protective actions + Promptly isolate the scene by removing all persans from the vicinity of the incident if for fire-fightors there is a fire. No action shall be taken involving any personal risk or without suitable training. Special protective Fire-fighters should wear appropriate protective equipment and self-contained breathing equipment for fire-fighters apparatus (SCBA) with a full face-piece operated in positive pressure made. Section 6. Accidental release measures Personal precautions, protective equipment and emersency procedures For non-emergency » No action shall be taken involving any personal risk or without suitable training personnel Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Avoid breathing vapor or mist Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate Put on appropriate personal protective equipment. Foremergency responders + [Fspecialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non- emergency personnel”. Environmental precautions; Avoid dispersal of spilled material and runoff and contact with soll. walenvays, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution {sewers, waterways. Sail or air) Methods and materials for containment and cleaning up Small spill + Stop leak if without risk. Move containers from spill area. Dilute with water and mop vp if water-soluble. Alternatively. or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. PABQME Dotan lois rasa Ne prewous validdtian, Verwen ot ana Prevent entry into sewers, water courses, basements or confined areas. Wash spillages into an effluent treatment plant or proceed as follows. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations {see Section 13}, Dispose of via a licensed waste disposal contractor, Contaminated absorbent material may pose the same hazard as the spilled product. Note: see Section 1 for emergency contact information and Section 13 far waste disposal. Section 7. Handling and storage Precautions for safe handling Protective measures Put on appropriate personal protective equipment (see Section 8). Avoid exposure - obtain special instructions before use. Avoid exposure during pregnancy. Do not handle until all safety precautions have been read and understoad. Do not get in eyes or on skin orclathing. Do not ingest. Avoid breathing vapor or mist. If during normal use the material presents a respiratory hazard, use only with adequate ventilation or wear appropriate respirator. Keep in the original container or an approved altemative made from a compatible material, kept tightly closed when nat in use. Emply containers retain product residue and can be hazardous, Do not reuse container. Advice on genoral Eating, drinking and smoking should be prohibited in areas where this material is handled occupational hygiene stored and processed. Workers should wash hands and face betore eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures Conditions for safe storage, + Do not store above the following temperature: -70°C (-94"F), Store in accordance with including any local regulations. Store in original container protected from direct sunlight in a dry, cool incempatibilitios and well-ventilated area. away from incompatible materials (see Section 10] and food and drink. Store locked up. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination Section 8. Exposure controlsipersonal protection Control parameters Occupational exposure limits Nane. Appropriate enginecring Tfuser operations generate dust, fumes, gas, vapor or mist, use process enclosures, controls local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits Environmental exposure + Emissions from ventilation or work pracess equipment should be checked to ensure they controls comply with the requirements of environmental protection legislation. In some cases. fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels, niividual protection measures Hygiene measures, » Wash hands. forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation lacation Eyoeface protection Safely eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists. gases or dusts. If contact is possible. the following protection should be wom, unless the assessment indicates a higher degree of protection: safety glasses with side-shields Skin protection That el iysue Taito Thaw ah FABER Chan cel uerenon tage igus vatidatig, — Wensiatt { ait Autivaities and Recombinant Proteins Section 8. Exposure controls/personal protection Hand protection Chemical-resistant. imperviaus gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Considering the parameters specified by the glove manufacturer, check during use that the gloves are stil retaining their protective properties. It should be noted that the time to breakthrough for any glove material may be different for diferent glove manufacturers. In the case of mixtures, consisting of several substances, the protection time of the gloves cannot be accurately estimated Badly protection Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Other skin protection . Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product Respiratory protection » Use a properly fitted. air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary, Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Section 9. Physical and chemical properties Appearance Physical state + Liquid Color » Not available Odor » Not available Odor threshold ~ Not available pH Not available Melting point + Not available Bailing point » Not available Flash point + Not available Burning time » Not applicable, Burning rate » Not applicable. Evaporation rate + Not available Flammability (solid, gas} » Not available Lower and uppor explosive » Not available (flammable) limits Vapor pressure » Not available Vapor density » Not available Relative density + Not available Soluhility » Soluble in the following materials: cold water and hot water. Solubility in water » Not available Eye contact + No known significant effects or critical hazards. Inhalation No known significant effects or critical hazards. FABANE f us vatiatiogs, Waste BAG Autivaities and Recombinant Proteins

2.1 Classification of the substance or mixture

Productiingrediont name

Aspiration hazard

Not available Information on the likely » Routes of entry anticipated: Oral, Dermal, Inhalation

TOXICOLOGICAL INFORMATION

Skin contact ; Na known significant effects or critical hazards, Ingestion ; Na known significant effects or critical hazards. Symptoms related to the piysical, chemical and toxicolodical characteristics Eye contact . No specific data Inhalation » Adverse symptoms may include the following reduced fetal weight increase in fetal deaths skeletal malformations Skin contact » Adverse symptoms may include the following reduced fetal weight increase in fetal deaths skeletal malformations Ingestion » Adverse symptoms may include the following reduced fetal weight increase in fetal deaths skeletal malformations Delayed and immediate cffects and also chronic effects from short and long term exposure Short term expasure Potential immediate » Not available cffects Potential delayed effects » Not available Lone term exposure Potential immediate + Nat available offects Potential delayed effects » Not available

Potential chronic health

effects Not available. General . No known significant effects or critical hazards. Carcinogenicity No known significant effects or critical hazards. Mutagenicity » No known significant effects or critical hazards, Teratogenivity « May damage the unbom child. Developmental effects Na known significant effects or critical hazards. Fertility effects . No known significant effects or critical hazards. Numerical measures of toxicity Not available.

ECOLOGICAL INFORMATION

Toxicity Productingredient name — | Result Species Exposure imidazole Acute EC50 130 mgil Algae 72 hours Acute EC50 82 mgil Fresh water Algae 96 hours Acute EC50 341.5 mgil Daphnia 48 hours Persistence and dedraclability Productingrediant name Aquatic half-life Photalysis Biodogradahility imidazole Readily No DrenOUS 4 orca ot Ho Productingredient name — |LagP BCF Potential imidazole 0.02 low Mobility in sail Soiliwater partition « Not available. cocfficiont (K

Other hazards

No known significant effects or critical hazards. Section 13. Disposal considerations Disposal methods » The generation of waste should be avoided or minimized wherever possible. Disposal of this product, solutions and any by-prodvels should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction, Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible. This material and its container must be disposed of in a safe way. Care should be taken when handling emptied containers that have not been Cleaned or rinsed out. Empty containers or liners may retain some product residues Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and SEWETS, Section 14. Transport information DOT Classification IATA

UN Number

Not regulated. UN proper shipping name Transport hazard class(us) Packing group Environmental S No. No

Additional information

Special precautions for user . Transport within user's premises: alvays transport in closed containers that are upright and secure. Ensure that persans transporting the praduct know what to doin the event of an accident or spillage. Transport in bulk according; Not available. to Annex Il of MARPOL 7478 and the IBC Code Mh TABZO13, ws vandal, asia BiG EZ H dias anal Recornbinarit Pratelis Section 15. Regulatory information U.S, Federal regulations TSCA 8(a) CDR Exempt/Partial exemption: Not determined United States inventory (TSCA 8h): All components are listed or exempted Clean Air Act Section 112 + Not listed (hi Hazardous Air Pollutants (HAPsi Clean Air Act Section 602: Notlisted Class [ Substances Clean Air Act Section 602 + Not listed Class Il Substances DEA List | Chemicals » Not listed (Precursor Chemicals) DEA List Il Chemicals » Natllisted (Essential Chemicals) SARA $02°244