General Information
Version
ACR20810
Revision date
2026-07-17
Product name
L(+)-Amethopterin hydrate
Product Synonyms
L(+)-4-Amino-N10-methylpteroylglutamic acid; MTX hydrate; Methotrexate hydrate
CAS No.
133073-73-1
supplier name
Fisher Scientific UK
Emergency telephone
001-800-227-6701, +32 14 57 52 11, 001-201-796-7100, +32 14 57 52 99, 001-800-424-9300, 001-703-527-3887
Icons in SDS
Company Information
company name
Fisher Scientific UK
e-mail address of the competent person responsible for the Safety Data Sheet
begel.sdsdesk@thermofisher.com
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H301, H340, H360
Hazard statements
Code
Statements
H301
Toxic if swallowed
Section 2
SECTION 2: Hazards identification
Physical State
Appearance/Odor
Powder Solid Yellow-orange Odorless Emergency Overview Toxic if swallowed. May cause genetic defects. May damage fertility or the unborn child. Sensitivity to light. Hygroscopic. Classification of the substance or mixture Acute Oral Toxicity Category 3 Germ Cell Mutagenicity Category 1B Reproductive Toxicity Category 1A Label Elements
Signal word
Danger Hazard Statements H301 - Toxic if swallowed H340 - May cause genetic defects H360 - May damage fertility or the unborn child
Prevention
P201 - Obtain special instructions before use P202 - Do not handle until all safety precautions have been read and understood P264 - Wash face, hands and any exposed skin thoroughly after handling P270 - Do not eat, drink or smoke when using this product P280 - Wear eye protection/ face protection
Response
P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P302 + P352 - IF ON SKIN: Wash with plenty of soap and water P308 + P313 - IF exposed or concerned: Get medical advice/attention P330 - Rinse mouth P332 + P313 - If skin irritation occurs: Get medical advice/attention P362 + P364 - Take off contaminated clothing and wash it before reuse
Storage
P405 - Store locked up
Disposal
P501 - Dispose of contents/ container to an approved waste disposal plant
Other physicochemical hazards
Hygroscopic.
Health hazards
Toxic if swallowed. May cause genetic defects. May damage fertility or the unborn child.
Environmental hazards
Contains no substances known to be hazardous to the environment or not degradable in waste water treatment plants. Is not likely mobile in the environment due its low water solubility. Spillage unlikely to penetrate soil. This product does not contain any known or suspected endocrine disruptors.
2.1 Classification of the substance or mixture
Acute Oral Toxicity Category 3 Germ Cell Mutagenicity Category 1B Reproductive Toxicity
