C-Myc Agarose Resin

SECTION 2: Hazards identification

(29 CFR 1910.1200) Emergency overview Physical state Liquid. [Slurry.] Color Off-white. Odor Odorless.

Hazard statements

NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. : NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. : NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. : MAY CAUSE EYE IRRITATION. CONTAINS MATERIAL THAT MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA.

Potential Acute Health Effects

Inhalation No known significant effects or critical hazards. Ingestion No known significant effects or critical hazards. Skin No known significant effects or critical hazards. Eyes No known significant effects or critical hazards. 9/24/2013. 1/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermoscientific.com/pierce Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax Inhalation No known significant effects or critical hazards. Ingestion No known significant effects or critical hazards. Skin No known significant effects or critical hazards. Eyes No known significant effects or critical hazards. Potential chronic health effects Inhalation No known significant effects or critical hazards. Ingestion No known significant effects or critical hazards. Skin No known significant effects or critical hazards. Eyes No known significant effects or critical hazards. Potential chronic health effects Inhalation Exposure to decomposition products may cause a health hazard. Serious effects may be delayed following exposure. Ingestion No known significant effects or critical hazards. Skin No known significant effects or critical hazards. Eyes Moderately irritating to eyes. 9/24/2013. 1/9 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermoscientific.com/pierce Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax Assay Buffer Potential chronic health effects

Potential chronic health

effects No known significant effects or critical hazards. Mutagenicity Carcinogenicity No known significant effects or critical hazards. No known significant effects or critical hazards. No known significant effects or critical hazards. 5/29/2013. 1/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermo.com Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax Lysis Buffer Carcinogenicity No known significant effects or critical hazards. Mutagenicity No known significant effects or critical hazards. Developmental effects No known significant effects or critical hazards. 5/29/2013. 1/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermo.com Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax Dilution Buffer Carcinogenicity No known significant effects or critical hazards. Mutagenicity No known significant effects or critical hazards. Developmental effects Contains material that may cause target organ damage, based on animal data. Mutagenicity Carcinogenicity No known significant effects or critical hazards. No known significant effects or critical hazards.

Teratogenic Effects

No known significant effects or critical hazards. Developmental effects No known significant effects or critical hazards. Fertility effects No known significant effects or critical hazards. Over-exposure signs/symptoms Inhalation No specific data. Ingestion No specific data. Skin No specific data. Eyes No specific data. Medical conditions : None known. aggravated by over- exposure See toxicological information (Section 11) E Composition/information on ingredients There are no ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. \4. First aid measures Eye contact : Check for and remove any contact lenses. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical attention if symptoms occur. Skin contact In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Clean shoes thoroughly before reuse. Get medical attention if symptoms occur. Inhalation : Move exposed person to fresh air. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms occur. Ingestion : Wash out mouth with water. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention if symptoms occur. Protection of first-aiders No action shall be taken involving any personal risk or without suitable training. Notes to physician No specific treatment. Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. 5. Fire-fighting measures Flammability of the product Ina fire or if heated, a pressure increase will occur and the container may burst. Extinguishing media Suitable Use an extinguishing agent suitable for the surrounding fire. Not suitable : None known. Special exposure hazards Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. 5. Fire-fighting measures Hazardous thermal Decomposition products may include the following materials: decomposition products carbon dioxide carbon monoxide Special protective Fire-fighters should wear appropriate protective equipment and self-contained breathing equipment for fire-fighters apparatus (SCBA) with a full face-piece operated in positive pressure mode. 6. Accidental release measures Personal precautions No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Put on appropriate personal protective equipment (see Section 8). Environmental precautions : Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Methods for cleaning up Small spill Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Large spill Stop leak if without risk. Move containers from spill area. Prevent entry into sewers, water courses, basements or confined areas. Wash spillages into an effluent treatment plant or proceed as follows. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations (see Section 13). Dispose of via a licensed waste disposal contractor. Note: see Section 1 for emergency contact information and Section 13 for waste disposal. 7. Handling and storage Handling Put on appropriate personal protective equipment (see Section 8). Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. Conclusion/Summary Not available. Reproductive toxicity Conclusion/Summary Not available. Canada Acute toxicity Conclusion/Summary To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity Conclusion/Summary Not available. lrritation/Corrosion Conclusion/Summary Not available. Sensitizer Conclusion/Summary Not available. Carcinogenicity Conclusion/Summary Not available. Mutagenicity Conclusion/Summary Not available. Conclusion/Summary Not available. Reproductive toxicity Conclusion/Summary Not available. No known significant effects or critical hazards. No known significant effects or critical hazards. Fertility effects No known significant effects or critical hazards. Over-exposure signs/symptoms Inhalation No specific data. Ingestion No specific data. Skin No specific data. Eyes No specific data. Medical conditions : None known. aggravated by over- exposure See toxicological information (Section 11) E Composition/information on ingredients There are no ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. \4. First aid measures Eye contact : Check for and remove any contact lenses. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical attention if symptoms occur. Skin contact In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Clean shoes thoroughly before reuse. Get medical attention if symptoms occur. Inhalation : Move exposed person to fresh air. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms occur. Ingestion : Wash out mouth with water. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention if symptoms occur. Protection of first-aiders No action shall be taken involving any personal risk or without suitable training. Notes to physician No specific treatment. Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. 5. Fire-fighting measures Flammability of the product Ina fire or if heated, a pressure increase will occur and the container may burst. Extinguishing media Suitable Use an extinguishing agent suitable for the surrounding fire. Not suitable : None known. Special exposure hazards Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Hazardous thermal No specific data. decomposition products 5/29/2013. Lysis Buffer 5. Fire-fighting measures Special protective Fire-fighters should wear appropriate protective equipment and self-contained breathing equipment for fire-fighters apparatus (SCBA) with a full face-piece operated in positive pressure mode. 6. Accidental release measures Personal precautions No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Put on appropriate personal protective equipment (see Section 8). Environmental precautions =: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Methods for cleaning up Small spill Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Large spill Stop leak if without risk. Move containers from spill area. Prevent entry into sewers, water courses, basements or confined areas. Wash spillages into an effluent treatment plant or proceed as follows. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations (see Section 13). Dispose of via a licensed waste disposal contractor. Note: see Section 1 for emergency contact information and Section 13 for waste disposal. 7. Handling and storage Handling Put on appropriate personal protective equipment (see Section 8). Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. Conclusion/Summary Not available. Reproductive toxicity Conclusion/Summary Not available. Canada Acute toxicity Conclusion/Summary To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity Conclusion/Summary Not available. lrritation/Corrosion Conclusion/Summary Not available. Sensitizer Conclusion/Summary Not available. Carcinogenicity Conclusion/Summary Not available. Mutagenicity Conclusion/Summary Not available. Conclusion/Summary Not available. Reproductive toxicity Conclusion/Summary Not available. No known significant effects or critical hazards. No known significant effects or critical hazards. Fertility effects No known significant effects or critical hazards. Over-exposure signs/symptoms Inhalation No specific data. Ingestion No specific data. Skin No specific data. Eyes No specific data. Medical conditions : None known. aggravated by over- exposure See toxicological information (Section 11) E Composition/information on ingredients There are no ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. \4. First aid measures Eye contact : Check for and remove any contact lenses. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical attention if symptoms occur. Skin contact In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Clean shoes thoroughly before reuse. Get medical attention if symptoms occur. Inhalation : Move exposed person to fresh air. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms occur. Ingestion : Wash out mouth with water. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention if symptoms occur. Protection of first-aiders No action shall be taken involving any personal risk or without suitable training. Notes to physician No specific treatment. Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. 5. Fire-fighting measures Flammability of the product Ina fire or if heated, a pressure increase will occur and the container may burst. Extinguishing media Suitable Use an extinguishing agent suitable for the surrounding fire. Not suitable : None known. Special exposure hazards Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Hazardous thermal No specific data. decomposition products 5/29/2013. 2/8 Dilution Buffer 5. Fire-fighting measures Special protective Fire-fighters should wear appropriate protective equipment and self-contained breathing equipment for fire-fighters apparatus (SCBA) with a full face-piece operated in positive pressure mode. 6. Accidental release measures Personal precautions No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Put on appropriate personal protective equipment (see Section 8). Environmental precautions =: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Methods for cleaning up Small spill Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Large spill Stop leak if without risk. Move containers from spill area. Prevent entry into sewers, water courses, basements or confined areas. Wash spillages into an effluent treatment plant or proceed as follows. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations (see Section 13). Dispose of via a licensed waste disposal contractor. Note: see Section 1 for emergency contact information and Section 13 for waste disposal. 7. Handling and storage Handling Put on appropriate personal protective equipment (see Section 8). Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. Conclusion/Summary Not available. Reproductive toxicity Conclusion/Summary Not available. Canada Acute toxicity Conclusion/Summary To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity Conclusion/Summary Not available. lrritation/Corrosion Conclusion/Summary Not available. Sensitizer Conclusion/Summary Not available. Carcinogenicity Conclusion/Summary Not available. Mutagenicity Conclusion/Summary Not available. Conclusion/Summary Not available. Reproductive toxicity Conclusion/Summary Not available. No known significant effects or critical hazards. Developmental effects No known significant effects or critical hazards. Fertility effects No known significant effects or critical hazards. Target organs Contains material which may cause damage to the following organs: upper respiratory tract, central nervous system (CNS). Over-exposure signs/symptoms Inhalation No specific data. Ingestion No specific data. Skin No specific data. Eyes Adverse symptoms may include the following: irritation watering redness Medical conditions Pre-existing disorders involving any target organs mentioned in this MSDS as being at aggravated by over- risk may be aggravated by over-exposure to this product. exposure See toxicological information (Section 11)

Storage

Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. 8. Exposure controls/personal protection Canada Occupational exposure limits No exposure limit value known. Consult local authorities for acceptable exposure limits. Recommended monitoring If this product contains ingredients with exposure limits, personal, workplace procedures atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to appropriate monitoring standards. Reference to national guidance documents for methods for the determination of Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. 8. Exposure controls/personal protection Canada Occupational exposure limits No exposure limit value known. Consult local authorities for acceptable exposure limits. Recommended monitoring — If this product contains ingredients with exposure limits, personal, workplace procedures atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to appropriate monitoring standards. Reference to national guidance documents for methods for the determination of hazardous substances will also be required. Engineering measures Good general ventilation should be sufficient to control worker exposure to airborne contaminants. 5/29/2013. 3/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermo.com Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax Lysis Buffer 8. Exposure controls/personal protection Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location. Personal protection Respiratory Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Hands Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Eyes Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: safety glasses with side-shields. Skin Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Environmental exposure Emissions from ventilation or work process equipment should be checked to ensure controls they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels. 19. Physical and chemical properties Physical state Liquid. pH : 6to8 /10. Stability and reactivity Chemical stability The product is stable. Conditions to avoid No specific data. Incompatible materials No specific data. Hazardous decomposition Under normal conditions of storage and use, hazardous decomposition products should products not be produced. Possibility of hazardous Under normal conditions of storage and use, hazardous reactions will not occur. reactions Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. 8. Exposure controls/personal protection Canada Occupational exposure limits No exposure limit value known. Consult local authorities for acceptable exposure limits. Recommended monitoring — If this product contains ingredients with exposure limits, personal, workplace procedures atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to appropriate monitoring standards. Reference to national guidance documents for methods for the determination of hazardous substances will also be required. Engineering measures Good general ventilation should be sufficient to control worker exposure to airborne contaminants. 5/29/2013. 3/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermo.com Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax Dilution Buffer 8. Exposure controls/personal protection Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location. Personal protection Respiratory Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Hands Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Eyes Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: safety glasses with side-shields. Skin Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Environmental exposure Emissions from ventilation or work process equipment should be checked to ensure controls they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels. 19. Physical and chemical properties Physical state Liquid. pH : 6to8 Solubility Soluble in the following materials: cold water and hot water. 110. Stability and reactivity Chemical stability The product is stable. Conditions to avoid No specific data. Incompatible materials No specific data. Hazardous decomposition Under normal conditions of storage and use, hazardous decomposition products should products not be produced. Possibility of hazardous Under normal conditions of storage and use, hazardous reactions will not occur. reactions

Hazardous Ingredients

will also be required 9/24/2013. 3/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermoscientific.com/pierce Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax 8. Exposure controls/personal protection Engineering measures : Good general ventilation should be sufficient to control worker exposure to airborne contaminants. Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location. Personal protection Respiratory Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Hands Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Eyes Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: safety glasses with side-shields. Skin Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Environmental exposure Emissions from ventilation or work process equipment should be checked to ensure controls they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels. 9. Physical and chemical properties Physical state Liquid. [Slurry.] Color Off-white. Odor Odorless. pH 7 Dispersibility properties Partially dispersible in the following materials: cold water and hot water. Solubility Partially soluble in the following materials: cold water. 10. Stability and reactivity Chemical stability The product is stable. Conditions to avoid No specific data. Incompatible materials No specific data. Hazardous decomposition Under normal conditions of storage and use, hazardous decomposition products should products not be produced. Possibility of hazardous Under normal conditions of storage and use, hazardous reactions will not occur. reactions

TOXICOLOGICAL INFORMATION

United States Acute toxicity Conclusion/Summary To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity Conclusion/Summary Not available. lrritation/Corrosion Conclusion/Summary Not available. Sensitizer Conclusion/Summary Not available. Carcinogenicity Conclusion/Summary Not available. Mutagenicity Conclusion/Summary Not available. United States Acute toxicity Conclusion/Summary To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity Conclusion/Summary Not available. Irritation/Corrosion Conclusion/Summary Not available. Sensitizer Conclusion/Summary Not available. §/29/2013. Lysis Buffer Carcinogenicity Conclusion/Summary Not available. Mutagenicity Conclusion/Summary Not available. United States Acute toxicity Conclusion/Summary To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity Conclusion/Summary Not available. Irritation/Corrosion Conclusion/Summary Not available. Sensitizer §/29/2013. 4/8 Dilution Buffer Conclusion/Summary Not available. Carcinogenicity Conclusion/Summary Not available. Mutagenicity Conclusion/Summary Not available.

ECOLOGICAL INFORMATION

Ecotoxicity No known significant effects or critical hazards. United States Aquatic ecotoxicity Conclusion/Summary Not available. Persistence/degradability Conclusion/Summary Not available. 9/24/2013. 5/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermoscientific.com/pierce Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax Not available. Persistence/degradability Conclusion/Summary Not available. Ecotoxicity No known significant effects or critical hazards. United States Aquatic ecotoxicity Conclusion/Summary Not available. Persistence/degradability Conclusion/Summary Not available. Canada Aquatic ecotoxicity Conclusion/Summary Not available. Persistence/degradability Conclusion/Summary Not available. 5/29/2013. 5/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermo.com Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax The generation of waste should be avoided or minimized wherever possible. Ecotoxicity No known significant effects or critical hazards. United States Aquatic ecotoxicity Conclusion/Summary Not available. Persistence/degradability Conclusion/Summary Not available. Canada Aquatic ecotoxicity Conclusion/Summary Not available. Persistence/degradability Conclusion/Summary Not available. 5/29/2013. 5/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermo.com Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax The generation of waste should be avoided or minimized wherever possible.

Other hazards

No known significant effects or critical hazards. 13. Disposal considerations Waste disposal The generation of waste should be avoided or minimized wherever possible.

Disposal

of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction. Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible. This material and its container must be disposed of in a safe way. Empty containers or liners may retain some product residues. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Disposal should be in accordance with applicable regional, national and local laws and regulations. Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. 14. Transport information Regulatory of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction. Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible. This material and its container must be disposed of in a safe way. Empty containers or liners may retain some product residues. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Disposal should be in accordance with applicable regional, national and local laws and regulations. Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. 14. Transport information Regulatory of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction. Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible. This material and its container must be disposed of in a safe way. Empty containers or liners may retain some product residues. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Disposal should be in accordance with applicable regional, national and local laws and regulations. Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. 14. Transport information Regulatory

UN Number

Proper shipping Classes PG* information name DOT Classification |Not - regulated. IATA-DGR Class Not - regulated. PG* : Packing group 15. Regulatory information United States |Proper shipping Classes PG* information name DOT Classification |Not - regulated. IATA-DGR Class Not - regulated. PG* : Packing group 15. Regulatory information United States |Proper shipping Classes PG* information name DOT Classification |Not regulated. IATA-DGR Class Not regulated. PG* : Packing group 15. Regulatory information United States

2.1 Classification of the substance or mixture

Not regulated. U.S. Federal regulati ons : TSCA 8(a) CDR Exempt/Partial exemption: Not determined United States inventory (TSCA 8b): At least one component is not listed. SARA 302/304: sodium azide SARA 311/312 Hazards identification: Not regulated. Clean Water Act (CWA) 311: disodium hydrogenorthophosphate Clean Air Act Secti on 112 Notlisted (b) Hazardous Air Pollutants (HAPs) Clean Air Act Section 602 Not listed Class I Substances 15. Regulatory information Clean Air Act Section 602 Not listed Class II Substances DEA List | Chemicals Not listed (Precursor Chemicals) DEA List II Chemicals Not listed (Essential Chemicals) State regulations Massachusetts None of the components are listed. New York None of the components are listed. New Jersey The following components are listed: Agarose Pennsylvania The following components are listed: Agarose United States inventory : Atleast one component is not listed. (TSCA 8b) Canada Not regulated. U.S. Federal regulati ons : TSCA 8(a) PAIR: Glycols, polyethylene, mono(p-(1,1,3,3-tetramethylbutyl)phenyl) ether TSCA 8(a) CDR Exempt/Partial exemption: Not determined United States inventory (TSCA 8b): All components are listed or exempted. SARA 302/304: Hydrogen chloride; ethylene oxide SARA 311/312 Hazards identification: Not regulated. Clean Water Act (CWA) 311: Hydrogen chloride Clean Air Act Secti on 112 Notlisted (b) Hazardous Air Pollutants (HAPs) Clean Air Act Section 602 Not listed Class I Substances Clean Air Act Section 602 Not listed Class Il Substances DEA List | Chemica Is Not listed (Precursor Chemicals) DEA List II Chemicals Not listed (Essential Chemicals) State requlations Massachusetts : None of the components are listed. 5/29/2013. Lysis Buffer 15. Regulatory information New York None of the components are listed. New Jersey None of the components are listed. Pennsylvania None of the components are listed. California Prop. 65 WARNING: This product contains less than 0.1% of a chemical known to the State of California to cause cancer. WARNING: This product contains less than 1% of a chemical known to the State of California to cause birth defects or other reproductive harm. Ingredient name Cancer Reproductive No significant risk |Maximum level acceptable dosage level 1,4-dioxane Yes. No. 30 g/day (ingestion) |No. 30 g/day (inhalation) ethylene oxide Yes. 2 ug/day (ingestion) |20 g/day (ingestion) 2 pg/day (inhalation) |20 pg/day (inhalation) United States inventory All components are listed or exempted. (TSCA 8b) Canada Not regulated. U.S. Federal regulations : TSCA 8(a) CDR Exempt/Partial exemption: Not determined United States inventory (TSCA 8b): All components are listed or exempted. SARA 302/304: Hydrogen chloride SARA 311/312 Hazards identification: Not regulated. Clean Water Act (CWA) 311: Hydrogen chloride Clean Air Act Section 112 Not listed (b) Hazardous Air Pollutants (HAPs) Clean Air Act Section 602 Not listed Class I Substances Clean Air Act Section 602 Not listed Class Il Substances DEA List | Chemicals Not listed (Precursor Chemicals) DEA List Il Chemicals Not listed (Essential Chemicals) State requlations Massachusetts : None of the components are listed. 5/29/2013. 6/8 Dilution Buffer 15. Regulatory information New York None of the components are listed. New Jersey None of the components are listed. Pennsylvania None of the components are listed. United States inventory All components are listed or exempted. (TSCA 8b) Canada

Further information

Label requirements : NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. Hazardous Material Information System (U.S.A.) Health Flammability Flammability Health Instability/Reactivity Special Date of printing 9/24/2013. date of issue > 9/24/2013. Date of previous issue 6/3/2013. Version 1.01 Prepared by : MSDS (Regulatory Specialist) V Indicates information that has changed from previously issued version. Notice to reader To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist. Lysis Buffer 1. Product and company identification Product name Lysis Buffer Supplier : Thermo Fisher Scientific Manufacturer : Thermo Fisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 815.968.0747 or 800.874.3723 7 AM - 5 PM Central Time 7 AM - 5 PM Central Time (GMT -06:00) Code : 0082013 1862807 1902006 MSDS # 9078 date of issue 6/29/2013. Print date 6/29/2013. Responsible name MSDS (Regulatory Specialist) CHEMTREC: 800.424.9300 Material uses Refer to the instruction Outside US: 703.527.3887 booklet for proper and intended use. Otherwise, contact supplier for specific applications. Product type Liquid. Emergency overview Physical state Liquid. Label requirements : NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. Hazardous Material Information System (U.S.A.) Health Flammability National Fire Protection Association (U.S.A.) Flammability Health Instability/Reactivity Special Date of printing 5/29/2013. date of issue 6/29/2013. Date of previous issue No previous validation. Version 1 Prepared by : MSDS (Regulatory Specialist) V Indicates information that has changed from previously issued version. Notice to reader To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist. 5/29/2013. Dilution Buffer 1. Product and company identification Product name Dilution Buffer Supplier : Thermo Fisher Scientific Manufacturer : Thermo Fisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 815.968.0747 or 800.874.3723 7 AM - 5 PM Central Time 7 AM - 5 PM Central Time (GMT -06:00) Code : 0082014 1862808 1902007 MSDS # 9079 date of issue 5/29/2013. Print date 5/29/2013. Responsible name MSDS (Regulatory Specialist) CHEMTREC: 800.424.9300 Material uses Refer to the instruction Outside US: 703.527.3887 booklet for proper and intended use. Otherwise, contact supplier for specific applications. Product type Liquid. Emergency overview Physical state Liquid. Label requirements : NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. Hazardous Material Information System (U.S.A.) Health Flammability Notice to reader To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist. 5/29/2013. 8/8 The world leader in serving science MSDS #9129 COVER SHEET Pierce qIP Protein Interaction 82015 Assay Reagent Kit Component # Description 1862822 Assay Buffer 1862428 Coelenterazine, 100x 82016 Pierce qIP Protein Interaction Assay Reagent Kit Component # Description 1862823 Assay Buffer 1862430 Coelenterazine, 100x Assay Buffer 1. Product and company identification Product name : Assay Buffer Supplier : Thermo Fisher Scientific Manufacturer : Thermo Fisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 815.968.0747 or 800.874.3723 7 AM - 5 PM Central Time 7 AM-5 PM Central Time (GMT -06:00) Code 1862822 1862823 1902115 MSDS # 9109 date of issue 9/24/2013. Print date 9/24/2013. Responsible name MSDS (Regulatory Specialist) CHEMTREC: 800.424.9300 Material uses Refer to the instruction Outside US: 703.527.3887 booklet for proper and intended use. Otherwise, contact supplier for specific applications. Product type Liquid. Emergency overview Physical state Liquid.

Physical hazards

The customer is responsible for determining the PPE code for this material. National Fire Protection Association (U.S.A.) 9/24/2013. 7/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermoscientific.com/pierce Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax The customer is responsible for determining the PPE code for this material. 5/29/2013. 7/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermo.com Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax Lysis Buffer The customer is responsible for determining the PPE code for this material. National Fire Protection Association (U.S.A.) Flammability Health Instability/Reactivity Special Date of printing : 5/29/2013. date of issue 5/29/2013. Date of previous issue No previous validation. Version 1 Prepared by : MSDS (Regulatory Specialist) V Indicates information that has changed from previously issued version. 5/29/2013. 7/8 Life Science Research PO Box 117 Rockford, IL (815) 968-0747 www.thermo.com Pierce Biotechnology Inc. 3747 N. Meridian Road 61105 (815) 968-7316 Fax Dilution Buffer

Signal word

CAUTION!

Precautionary statements

Do not breathe vapor or mist. Do not eat, drink or smoke when using this product. Avoid contact with eyes. Wash thoroughly after handling.