Binding Buffer

Hazard statements (CLP)

H302, H315, H319, H335, H402, H412

Code

Statements

H302

Harmful if swallowed

Signal word

WARNING

Health hazards

Acute oral toxicity Category 4 ISkin corrosion/irritation Category 2 Serious eye damage/eye irritation Category 2A Specific target organ systemic toxicity (single exposure) Category 3

Physical hazards

Not Hazardous

Hazard statements

H302 Harmful if swallowed H315 - Causes skin irritation H319 - Causes serious eye irritation H335 - May cause respiratory irritation H412 - Harmful to aquatic life with long lasting effects H402 - Harmful to aquatic life

Precautionary statements

P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell P302 + P352 - IF ON SKIN: Wash with plenty of soap and water P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing P273 - Avoid release to the environment P264 - Wash hands thoroughly after handling P332 + P313 - If skin irritation occurs: Get medical advice/attention P337 + P313 - If eye irritation persists: Get medical advice/attention P261 - Avoid breathing dust/fume/gas/mist/vapors/spray P330 - Rinse mouth P280 - Wear protective gloves/protective clothing/eye protection/face protection P312 - Call a POISON CENTER or doctor/physician if you feel unwell P270 - Do not eat, drink or smoke when using this product P271 - Use only outdoors or in a well-ventilated area P362 + P364 - Take off all contaminated clothing and wash it before reuse

Potential health effects

eyes Irritating to eyes. Skin Harmful in contact with skin. inhalation May be harmful by inhalation. Ingestion Harmful if swallowed. Specific effects Carcinogenic effects None. Mutagenic effects None. Reproductive toxicity None. Sensitization None. Target Organ Effects None under normal use conditions. HMIS Health 2 Flammability 0 Reactivity 0 Thiocyanic acid, compound with 593-84-0 209-812-1 30 - 60 guanidine (1:1) 593-84-0 (30 - 60 Contact with acids or bleach liberates toxic gases. DO NOT) D acids or bleach to any liquid wastes containing this product. We recommend handling all chemicals with caution. Skin contact Wash off immediately with plenty of water for at least 15 minutes. Take off all contaminated clothing and wash it before reuse. Immediate medical attention is required. Eye contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required. Ingestion Call a physician or poison control center immediately. Never give anything by mouth to an unconscious person. Do not induce vomiting without medical advice. inhalation Remove to fresh air. If not breathing, give artificial respiration. Call a physician or poison control center immediately. Most important symptoms and effects, both acute and delayed H302 - Harmful if swallowed, H315 - Causes skin irritation, H319 - Causes serious eye irritation, H335 - May cause respiratory irritation, H412 - Harmful to aquatic life with long lasting effects, H402 - Harmful to aquatic life Notes to Physician Treat symptomatically. Suitable extinguishing media Water spray. Carbon dioxide (CO2). Foam. Dry chemical. Special protective equipment for firefighters Wear self-contained breathing apparatus and protective suit. Specific hazards arising from the chemical Not known Personal precautions Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Use personal protection equipment. Methods for cleaning up Soak up with inert absorbent material. Environmental precautions Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. See Section 12 for more information. Handling Always wear reccommended Persona) Protective Equipment. No special handling advices are necessary.

Storage

Keep in a dry, cool and well-ventilated place. Keep in properly labeled containers. . Exposure Limits hemIca1 AM MSHA,PEL (Ceiling OEL (TWA H OEL (STEL) Thiocyanic acid, None compound with guanidine Ensure (1:1) Engineering measures adequate ventilation, especially in confined areas. Personal Protective Equipment Personal Protective Equipment requirements are dependent on the user institution’s risk assessment and are specific to the risk assessment for each laboratory where this material may be used. Respiratory protection In case of insufficient ventilation, wear suitable respiratory equipment. Hand protection Impervious gloves. Handle Eye protection Goggles. Skin and Body Protection Lightweight protective clothing. Hygiene measures in accordance with good industrial hygiene and safety practice. Environmental exposure Prevent product from entering drains. Do not allow material to contaminate ground controls water system. General information Form Liquid

Appearance/Odor

Colorless odorless Odor Threshold Mixture has not been tested Boiling point / boiling range C No data available OF No data available Melting point / melting range C No data available OF No data available flash point C No data available OF No data available Autoignition Temperature C No data available OF No data available Evaporation rate No data available Flammability (solid, gas) No data available Oxidizing properties Mixture has not been tested Water solubility soluble Upper explosion limit No data available Lower explosion limit No data available Partition coefficient: No data available n-octanol/water Vapor Pressure No data available vapor density No data available Viscosity Mixture has not been tested pH value No data available Stability Stable under normal conditions. Contact with acids or bleach liberates toxic gases. DO NOT ADD acids or bleach to any liquid wastes containing this product. Materials to avoid Strong oxidizing agents. Strong acids. Cyanide compounds. sodium hypochlorite. Possibility of hazardous Hazardous reaction has not been reported reactions Hazardous decomposition Carbon oxides, Nitrogen Oxides. Sulphur oxides. products polymerization None under normal processing. Conditions to avoid None under normal processing. .. ... Acute Toxicity hemIcai Nam 5O(oraIrÆtImouM’ 050(dÆrthI,ftL Thiocyanic acid, compound with 593 mg/kg No data available guanidine (1:1) Principle Routes of Exposure Potential Health Effects eyes Irritating to eyes. Skin Harmful in contact with skin. inhalation May be harmful by inhalation. Ingestion Harmful if swallowed. Carcinogenic effects None. Mutagenic effects None. Reproductive toxicity None. Sensitization None. Target Organ Effects None under normal use conditions Chronic aquatic toxicity Category Category 3. Ecotoxicity Hazardous to the Aquatic Environment. Acute aquatic toxicity 3. Mobility No information available. Biodegradation No information available. Bioaccumulation No information available. Dispose of contents/containers in accordance with local regulations. I IATA Proper Shipping Name No dangerous good in sense of these transport regulations Hazard Class None Subsidiary class None Packing group None UN-No none Environmental hazards None d, compound with 593-84-0 ( 30 -60 US Federal Regulations SARA 313 This product is not regulated by SARA. Clean Air Act, Section 112 Hazardous Air Pollutants (HAPs) (see 40 CFR 61) This product does not contains HAPs. US State Regulations California Proposition 65 This product does not contain any Proposition 65 chemicals. WHMIS Hazard Class D213 - Toxic materials This 0 product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPA. Reason for revision SIDS sections updated. For research use only. Not intended for human or animal diagnostic or therapeutic uses. The above information was acquired by diligent search and/or investigation and the recommendations are based on prudent application of professional judgment. The information shall not be taken as being all inclusive and is to be used only as a guide. All materials and mixtures may present unknown hazards and should be used with caution. Since the Company cannot control the actual methods, volumes, or conditions of use, the Company shall not be held liable for any damages or losses resulting from the handling or from contact with the product as described herein. THE INFORMATION IN THIS SDS DOES NOT CONSTITUTE A WARRENTY, EXPRESSED OR IMPLIED, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PUPOSE’ End of Safety Data Sheet Thermo Fisher Safety Data Sheet S I ENTI FtC Identification of the substance or mixture Product code K0702COMPONENTC Product name Elution Buffer Company/undertaking identification Manufacturer/Supplier Thermo Fisher Scientific Baltics UAB V.Graiciuno 8 LT-02241 Vilnius Lithuania Tel.: +37052602131 Fax.: +370 52602142 Emergency telephone number For Chemical Emergency (Spill, Leak, Fire, Exposure or Accident), call CHEMTREC Domestic North America: 1-800-424-9300 (24 hours) CHEMTREC International: 1-703-527-3887 (collect calls accepted) Country specific Emergency Number (if available): Health hazards Not classified Physical hazards Not classified Hazard Statements Not Applicable Precautionary Statements Not Applicable Principle Routes of Exposure Potential Health Effects eyes May cause eye irritation with susceptible persons. Skin May cause skin irritation in susceptible persons. inhalation May be harmful by inhalation. Ingestion May be harmful if swallowed. SDecific effects Carcinogenic effects None. Mutagenic effects None. Reproductive toxicity None. Sensitization None. Target Organ Effects No known effects under normal use conditions. Health 0 Flammability 0 Reactivity 0 The product contains no substances which at their given concentration, are considered to be hazardous to health. Skin contact Rinse cautiously with water for several minutes. Immediate medical attention is not required. Eye contact Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Ingestion Not expected to present a significant ingestion hazard under anticipated conditions of normal use. If you feel unwell, seek medical advice. inhalation Not expected to be an inhalation hazard under anticipated conditions of normal use of this material. Consult a physician if necessary.