n-Butyllithium

Potential Acute Health Effects

Corrosive to skin, eyes, and respiratory system. Liquid or spray mist may produce tissue damage, particularly in mucous membranes of the eyes, mouth and respiratory tract. Skin contact may produce burns. Eye contact can result in corneal damage or blindness. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Corrosive materials may cause serious injury if ingested. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

Potential chronic health

CARCINOGENIC EFFECTS : Not available. MUTAGENIC EFFECTS : Not available.

Teratogenic Effects

TUMORIGENIC EFFECTS Hexane: Rat TCLo (inhalation) 1000ppm/4 Hours/59 Weeks, intermittent. Toxic Effects: Tumorigenic- Carcinogenic by RTECS criteria. Tumorigenic Effects- Testicular tumors. Mouse TCLo (inhalation) 9018ppm/6 Hours/2 Years, intermittent. Toxic Effects: Tumorigenic- Neoplastic by RTECS criteria. Liver- Tumors. DEVELOPMENTAL TOXICITY : REPRODUCTIVE EFFECTS: Hexane: Rat TCLo (inhalation) 5000ppm/20 Hours, female, 6-19 Days of pregnancy. Toxic Effects: Effects on Embryo or Fetus- Fetotoxicity. Rat TCLo (inhalation) 1000ppm/6 Hours, female, 8-16 Days of pregnancy. Toxic Effects: Effects on Newborn- Growth statistics. Mouse TDLo (oral) 238gm/kg, female, 6-15 Days of pregnancy. Toxic Effects: Effects on Embryo or Fetus- Fetotoxicity. Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection. (ca 15% in Hexane) Section IV.