WB Aliphatic Prepolymer -23

SECTION 2: Hazards identification

As defined by OSHA Hazard Comm. Std.,29 CFR 1910.1200)

Physical hazards

None (see section 5)

Health hazards

Based on HDI-irritant (eye, skin, respiratory, passages, skin sensitizer), Inhalation (TLV), Harmful (respiratory sensitizer, lung injury. General: No toxicity information is available on this specific preparation as this health assessment is based on information available on the individual components. Ingestion: A single dose of this product is practically non-toxic by ingestion. Irritation of the mouth, pharynx, esophagus and stomach can develop following consumption. Eye Contact: This material will irritate the eye and eye protection must be used at times when handling this product. Consult physician immediately. Skin Contact: This material may irritate the skin with prolonged use, latex gloves should always be used. Skin sensitization and irritation will develop with repeated contact with skin. Preliminary data from a particular research study indicates HDI in corn oil injected intra-dermal In guinea pigs can cause a respiratory sensitization reaction. The potential for HDI to induce a res- also be induced by repeated skin contact and/or absorption. Toxic concentrations of this product will not probably be absorbed through the human skin. DATA may result in permanent decreases in lung function. An over-exposure study was completed where Inhalation: Vapors and aerosols will irritate eyes, nose and respiratory passages. Severe over- exposure may lead to edema. HDI can induce respiratory sensitization with asthma-like symptoms. Symptoms include cough, tightness of chest with difficultly in breathing. These symptoms may be immediate or delayed up to several hours after exposure. There are reports that chronic exposures groups of rats were exposed for 6 hours/day, 5 days/week to atmospheres of polymeric HDI aero- SECURE chronic irritation and lung damage. Therefore, in the absence of these severe prolonged exposures, sol. Overall, the tumor incidence, both benign and malignant, were not different from the control animals which were not subjected. However, at the top level only 96 mg/m3, there was a significant incidence of benign tumors of the lung (Adenoma) and one malignant tumor (Aden carcinoma). There were no lung tumors at 1mg/m3 and no effects at .2 mg/m3. The increased incidence of lung tumors is associated with prolonged respiratory exposure and the concurrent accumulation of yel- low material in the lung, which occurred through the study. These high concentrations lead to it is highly unlikely that tumor formation will occur.