ULTRAWEED SUPER

SECTION 2: Hazards identification

Main hazard: A relatively low toxicity herbicide. Poisonous if swallowed. Irritating to eyes and respiratory system. Flammability: Water based product, non-flammable. Chemical hazard: Simazine: R 40. Possible risks of irreversible effects. Most mammals tend to be insensitive to simazine. For unknown reasons, sheep and cattle are especially susceptible to poisoning by simazine. Doses of 500 mg/kg were fatal in sheep with death delayed for 5 to 16 days. Symptoms exhibited by poisoned sheep include lower food intake, higher water intake, incoordination, tremors, and weakness, especially in the hindquarters. Sheep show liver damage, (see also section 12: Bio- accumulation); Terbuthylazine: R22. Harmful if swallowed. Glyphosate: Irritating to eyes. (Risk of serious damage to eyes). Biological hazard: Highly toxic to algae. Dangerous to fish. Reproductive hazard: Glyphosate: Most of the field and laboratory evidence shows that glyphosate produces no reproductive changes in test animals; it is unlikely that the compound would produce any reproductive effects in humans. It did not cause any teratogenic effects (birth defects). Simazine: No adverse effects on reproductive capacity or development were observed in a three generation study of rats fed 5 mg/kg/day simazine. Eye effects: eyes: Glyphosate: Irritating to eyes. Simazine: Non-irritating to skin and eyes (rabbits). Terbuthylazine: No skin or eye irritation; not a skin sensitizer.

Health Effects - Skin

Glyphosate: Non-irritating to skin (rabbits); Glyphosate – Dermal LD50 (rat) > 5000 mg/kg. Simazine: Dermal LD50 (rat) > 3100 mg/kg; (Non-irritating to skin and eyes (rabbits). Simazine is slightly toxic via dermal exposure. Terbuthylazine: Dermal LD50 (rat) > 3000 mg/kg; (Non-irritant to eyes and slightly to skin of rabbits).

Potential health effects

ingestion Glyphosate: Oral LD50 (rat) > 5000 mg/kg. Simazine: Oral LD50 (rat) > 5000 mg/kg. Irritating to respiratory system. Avoid inhalation of vapour or spray mist. Simazine is moderately toxic if ingested. No cases of poisoning in humans have been reported from ingestion of simazine. Terbuthylazine: Oral LD50 (rat) = 2000 mg/kg. inhalation Glyphosate: LC50 (4h) for rats > 12.2 mg/ℓ air. Simazine: LC50 (4h) for rats> 2 mg/ℓ air. Simazine is highly toxic if inhaled (especially important at manufacturing sites). The final product is relatively safe if all the precautions and personal protections related to the pesticide are followed. Terbuthylazine: LC50 (4h) for rats > 3.51 mg/ℓ air. Carcinogenicity: Simazine - Carcinogenic category 3 Substance which may cause concern for man owing to possible carcinogenic effects but in respect of which the available information is not adequate for making a satisfactory assessment. Because simazine in drinking water may possibly increase the risk of cancer in humans, the Lifetime Health Advisory level (LHA = 1 g/ℓ) set by EPA includes an additional margin of safety. Simazine did not produce tumors in mice given 215 mg/kg/day, the highest dose tolerated, for 18 months. Simazine produced thyroid and mammary tumors in female rats fed 5 mg/kg, the highest dietary dose tested. Glyphosate: US EPA has stated that there is sufficient evidence to conclude that glyphosate is not carcinogenic in humans. Mutagenicity: Simazine: Animal studies did not detect any mutagenic effects. No human information available. Terbuthylazine: Not mutagenic in a series of tests using bacteria, cultured mammalian cells and whole animals. No human information available. Glyphosate: Does not cause mutations in microbes. The compound poses little mutagenic risk to humans. Neurotoxicity: Simazine: In case of heavy intoxication, symptoms of excitement and depression of the central nervous system may appear. Terbuthylazine: In case of heavy intoxication, symptoms of excitement and depression of the central nervous system may appear. Glyphosate: Hens fed massive amounts over three days and again 21 days later showed no nerve related effects.