General Information
Revision date
2013-06-03
Product name
METHOTREXATE, USP
Product Synonyms
Amethopterin; (+)-Amethopterin; Amethopterine; 4-Amino-4-deoxy-N(sup 10)- methylpteroylglutamate; 4-Amino-4-deoxy-N(sup 10)-methylpteroylglutamic acid; 4-
Chemical name
Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, L-
CAS No.
59-05-2
1.2.1 Relevant identified uses
Medication
supplier name
Spectrum Chemicals and Laboratory Products, Inc
Emergency telephone
1-800-424-9300
Icons in SDS
Company Information
company name
Spectrum Chemicals and Laboratory Products, Inc
Section 2
SECTION 2: Hazards identification
29 CFR 1910.1200) EMERGENCY OVERVIEW WARNING!. Harmful if swallowed. May cause skin and eye irritation. May cause irritation of respiratory tract. Odor: Physical state: Appearance: Color: None. Solid. Crystalline powder. Yellow.
Principle Routes of Exposure
Ingestion. Inhalation.
Potential Acute Health Effects
Skin Contact: May cause skin irritation. Eye Contact: Contact with eyes may cause irritation. Inhalation: May cause irritation of respiratory tract. Ingestion: Harmful if swallowed. Causes digestive (gastrointestinal) tract irritation. May cause abdominal pain. May cause nausea and vomiting. May cause diarrhea. May cause constipation. It may affect the kidneys. May affect the blood. May affect the bone marrow. May affect respiration. May affect the liver. It may affect the brain. May cause central nervous system effects. May affect the cardiovascular system. Chronic Potential Health Effects: Component Carcinogen Status: Methotrexate Group 3- Not classifiable as to its carcinogenicity to humans by IARC 59-05-2 (100) Target Organs: Bone Marrow. Blood. Liver. Kidneys.
Teratogenic Effects
Can cause birth defects Mutagenic Effects: May affect genetic material Mutations in microorganisms Experiments with bacteria and/or yeast have shown mutagenic effects Mutagenic effects in mammalian somatic cells Experiments with animal lymphocytes have shown mutagenic effects
Medical Conditions Generally Aggravated by Exposure
No information available See Section 11 for additional Toxicological Information
Environmental effects
No information available
