ELASTOCOL STICK

Potential health effects

I drunkenness, drowsiness, nausea and vomiting. Unconsciousness may result if exposure is extremely high (greater than 10000 ppm). Effects of Short-Term (Acute) Exposure ] Intolerable nose and throat irritation would also occur at these concentrations. Even higher concentrations can cause collapse, coma INHALATION Inhalation of vapours of this product can occur while using the product. and death. (1) The exposition to these vapours over exposure limits may cause SKIN CONTACT irritation of the respiratory system and CNS depression (headaches, Prolonged or repeated contact may cause defatting of the skin and dizziness, nausea, tiredness, confusion and coma). produce dermatitis (dryness, irritation, redness and cracking). Naphtha: The main effect of short-term inhalation exposure is Naphtha: Naphtha is a moderate to severe skin irritant, based on depression of the CNS. The effects reported in studies with volunteers human information. Harmful effects are not expected to occur by skin at 5000 ppm were marked dizziness/giddiness (at minutes); absorption. (1) incoordination (at minutes); hilarity or a state of stupor (at Acetone: Acetone is a non-irritant to very mild irritant, based on animal minutes) that persisted for 30 minutes after exposure. Subjects reported and limited human information. The risk of developing health effects reduced appetite, slight nausea and a gasoline-like taste that persisted following the absorption of acetone through unbroken skin is very for several hours after exposure. Lower exposures produced only slight slight. (1) dizziness (1 000 ppm for 6 minutes or 2 000 ppm for 4 minutes). The fatal concentration has been reported to be 16000 ppm. Mucous EYE CONTACT membrane irritation may occur at high vapour concentrations. (1) The vapours may cause eye irritation with tearing and discomfort, redness and pain. Eye contact with the product may cause moderate to Acetone: In one study, volunteers exposed to concentrations up to 500 severe irritation. ppm reported no harmful effects. In other studies, concentrations of approximately 300-500 were reported to cause slight irritation of the Naphtha: Based on a report of skin irritation, eye contact with the nose and throat. Exposure to 250 ppm for 4 hours has caused mild liquid may result in irritation and pain. Concentrated vapour may cause effects on performance in some behavioural tests (auditory tone slight irritation. However, during exposure to 5 000 ppm for 4 minutes discrimination and a mood test). As concentrations approach there were no complaints of eye irritation. There is no human or animal 1 000 ppm, noticeable irritation has occurred and some people have information available. (1) reported headaches, light-headedness and tiredness. Inhalation of Acetone: Acetone is a severe irritant, based on animal and limited concentrations higher than 2 000 ppm can cause dizziness, a feeling of human information. (1) INGESTION NERVOUS SYSTEM It is unlikely that toxic amounts of this product would be ingested with Naphtha: Damage to the nervous system of the extremities (the hands, normal handling and use. If significant amount of the product were arms, legs and feet) has been observed in people occupationally ingested, symptoms as described for inhalation might occur. This exposed to naphtha. This condition is referred to as peripheral product may cause irritation, mouth and throat burns and abdominal neuropathy. The majority of occupational cases have occurred in small pains. The product can be aspirated (inhaled) into the lungs during industries where there was exposure to relatively high concentrations, ingestion or vomiting. Aspiration of even a small amount of liquid usually for more than 8 hours/day. (1) could result in a life threatening accumulation of fluid in the lungs. Acetone: No conclusions can be drawn from the human information Severe lung damage (oedema), respiratory failure, cardiac arrest and located. Studies in animals have not shown neurotoxic effects from death may result. acetone. (1) Naphtha: Animal toxicity information indicates that Naphtha has very CARCINOGENICITY Naphtha: There is no human or animal information available. The nausea, vomiting, headache and other symptoms of CNS depressi International Agency for Research on Cancer (LARC) has not evaluated described for “Inhalation” above. (1) the carcinogenicity of this chemical. The American Conference of Acetone: Ingestion is not a typical route of occupational exposure. Governmental Industrial Hygienists (ACGIH) has not assigned a Several studies report no effects or minor effects (slight drowsiness) in carcinogenicity designation to this chemical. The US National people who ingested up to 20 grams/day for several days. Animal Toxicology Program (NTP) has not listed this chemical in its report on toxicity information also sug that acetone is not very toxic carcinogen. (1) following ingestion. If acetone is aspirated (breathed into the lungs Acetone: Acetone is not known during to be ingestion or vomiting) a carcinogen. IARC has not it can cause severe, life-threatening lung evaluated the carcinogenicity of this chemical. ACGIH has designated injury. Animal information suggests that acetone would be difficult to this chemical as not classifiable aspirate as a human carcinogen (A4). Note: because it evaporates so quickly. Based on its physical ACGIH has published a Notice of Intended Change properties, acetone can be aspirated into the lungs during ingestion or to remove the designation of A4 (not classifiable as a human carcinogen). NTP has vomiting. (1) not listed this chemical in its report on carcinogens. (1) Effects of Long-Term (Chronic) Exposure TERATOGENICITY, EMBRYOTOXICITY, FETOTOXICITY INHALATION Naphtha: There is no human information available. Naphtha has not Naphtha: Nerve damage of the extremities, such as the hands and feet produced teratogenicity or embryotoxicity in the few animal studies (peripheral neuropathy) has been reported in workers exposed to available. Fetotoxicity has been observed in the presence of maternal petroleum solvents containing mixtures of chemicals including toxicity. (1) heptane. (1) Acetone: The information located is not sufficient to conclude that SKIN CONTACT acetone causes developmental toxicity. No conclusions can be drawn Naphtha: Prolonged or repeated skin contact may cause dry, red, itchy based on the limited human information available. In animal studies, skin (dermatitis). (1) inhalation of acetone caused fetotoxicity in rats and mice and embryotoxicity in mice, but only at concentrations that also caused Acetone: Prolonged or repeated contact may cause defatting of the skin maternal toxicity. (1) and produce dermatitis (dryness, irritation, redness and cracking). (1) REPRODUCTIVE TOXICITY SKIN SENSITIZATION Naphtha: There is no human information available. Naphtha: There have been no reports of skin sensitization Naphtha has in people caused severe testicular damage in male rats at concentrations which occupationally exposed to naphtha. Skin sensitization was not observed have produced significant other toxicity. (1) in a maximization test using 25 volunteers. (1) Acetone: The information located is not sufficient to conclude that Acetone: Acetone is not a skin sensitizer. (1) acetone causes reproductive toxicity. No conclusions can be drawn EYES/VISION from the limited human information available. In an oral study in rats, Naphtha: Limited information suggests that naphtha may cause effects on sperm were observed at a dose that caused significant other harmful vision changes such as blurred vision, impaired colour toxicity. (1) discrimination, reduced responsiveness of the eye to visual stimulation MUTAGENICITY and constriction of visual field. The available studies have involved Naphtha: The available information does not suggest that naphtha small numbers is of employees and exposure concentrations have mutagenic. Negative results were obtained in most generally been high (e.g. 423 to tests using live 1 280 ppm for 5 years with higher peak animals and relevant routes of exposure. Positive results (chromosomal concentrations). It has been suggested that these effects may be aberrations in bone marrow) were observed in male rats exposed by correlated with signs of peripheral neuropathy. (1) inhalation, but the purity of the sample was not specified. No human TARGET ORGANS information was located. Negative results were obtained in cultured Naphtha: Long-term exposure of rubber tire workers to a solvent human cells (DNA damage, unscheduled DNA synthesis), with or mixture which included heptane caused some slight blood disorders. without metabolic activation. (1) No conclusions can be drawn from this report because of the combined Acetone: Acetone is not known to be a mutagen. No human exposure. (1) information was located. There are no confirmed studies that show HEART/BLOOD VESSELS mutagenicity in live animals. (1) Acetone: No statistically significant differences in mortality from TOXICOLOGICALLY SYNERGISTIC MATERIALS circulatory system or heart disease were observed in 948 employees Naphtha: The neurotoxic effects of naphtha vapour can be enhanced in exposed to up to 1 070 ppm acetone for up to 23 years, when compared rats by both methyl ethyl ketone (MEK) and lead acetate, but are with the general United States population.(1) decreased by toluene. Pulmonary lesions in rats were also reported to BLOOD/BLOOD FORMING SYSTEM be enhanced by co-exposure to MEK. Both toluene and xylene prevent Acetone: No significant changes in blood composition or chemistry testicular atrophy by naphtha. (1) were found in 60 workers who had worked at least 5 years in the acetate fibre manufacturing industry (exposures of 550-1 050 ppm). (1) Acetone: A major effect of acetone is its enhancement of the toxicity of FIRE FIGHTING INSTRUCTIONS many