Brimonidine Tartrate Ophthalmic Solution, 0.1%

SECTION 2: Hazards identification

OSHA Hazards Classification

2.2 Label elements

Emergency Overview The product contains no substances which at their given concentration, are considered to be hazardous to health Appearance Liquid Physical state Liquid Odor Slight Chemical Name Potassium Chloride Symptoms The most common adverse reactions to potassium chloride are nausea, vomiting, flatulence, abdominal pain/discomfort, and diarhhea. One the most severe adverse side effects is hyperkalemia, There have also been reports of upper and lower gastrointestinal conditions including obstruction, bleeding, ulceration, and perforation. Brimonidine tartrate Prolonged or repeated exposure can cause central nervous system effects. allergic conjunctivitis, burning sensation, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, hypertension, ocular allergic reaction, oral dryness, and visual disturbance. Chemical Name Potassium Chloride

Medical Conditions Generally Aggravated by Exposure

Contraindications occur in patients with hyperkalemia since a further increase in serum potassium concentration in such patients can produce cardiac arrest. Hyperkalemia may complicate the following conditions: chronic renal failure, systemic acidosis, acute dehydration, extensive tissue beak down and adrenal insufficiency. Other contraindications occur in any patient in whom there is structural, pathological or pharmacologic cause for arrest or delay in tablet passage Brimonidine tartrate through the gastrointestinal tract. Antihypertensives/cardiac glycosides may lower blood pressure. Use with CNS depressants may result in an additive or potentiating effect. Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine. Monoamine oxidase inhibitors may result in increased hypotension.

Further information

Unknown Acute Toxicity 99.9% of the mixture consists of ingredient(s) of unknown toxicity

2.1 Classification of the substance or mixture

OSHA Regulatory Status This chemical is not considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.122) Not a dangerous substance or mixture according to the Globally Harmonized System (GHS)