S-HyNic

Hazard statements (CLP)

H301+H331, H302, H317, H320, H335

Code

Statements

H301+H331

Toxic if swallowed or if inhaled

SECTION 2: Hazards identification

Number Sodium phosphate, 10049-21-5 <1% 231-449-2 Xi, R 36/37/38 monobasic Sodium phosphate, 7558-79-4 <1% 231-448-7 Xi, R 36/37/38 dibasic Sodium chloride 7647-14-5 <1% 231-598-3 Xi, R 36/37/38 Water 07732-18-5 98% N/A Not controlled

HMIS® ratings

Scale 0-4) Health = 2 Fire =1 Reactivity =1 A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid 13 (Scale 0-4) Health = 1 Fire =1 Reactivity = 0 A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid (Scale 0-4) Health = 1 Fire =1 Reactivity = 0 A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid 31 (Scale 0-4) Health = 1 Fire = 1 Reactivity = 0 A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid (Scale 0-4) Health = 2 Fire =1 Reactivity = 0 NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid (Scale 0-4) Health = unknown Fire = unknown Reactivity = unknown A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Off-white dry residue that is clear when resuspended in an appropriate solvent. (Scale 0-4) Health = 1 Fire = 1 Reactivity = 0 A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid

Potential health effects

Acute Eye: Direct contact may cause irritation with redness Acute Skin: Direct contact may cause skin irritation with redness. Acute Inhalation: Acute and chronic exposure may cause irritation of the mucous membranes. Symptoms may include tightness and difficulty breathing. Acute ingestion: Acute exposure may cause gastrointestinal irritation to the mouth and stomach. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. V. Fire Fighting Measures Fire Hazard Data: Fire: This product is not considered to be a fire hazard. Auto-ignition: Unknown Flash Point: Unknown Flammability Limits (vol/vol%): Unknown Lower: Unknown Upper: Unknown Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. Unusual Fire and Explosion Hazards: None 14 VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. VII. Handling and Storage Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material refrigerated. Keep container tightly sealed at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: Ingredient ACGIH NIOSH OSHA-PELs Name Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 dibasic PEL-STEL 3 mg/ m3 Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 monobasic PEL-STEL 3 mg/ m3 Sodium N/A chloride Engineering Controls: Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. 15 IX. Physical and Chemical Properties Component: 1X Modification Buffer Physical Appearance: Clear colorless liquid Percent Purity: Not available Boiling Point: Not available Melting Point: Not available Specific gravity: Not available Freezing Point: Not Available Vapor pressure: Not available Vapor density: Not available Solubility: aqueous solutions Evaporation rate: Not available pH:8.0 X. Stability and Reactivity Chemical Stability: This compound is considered stable. Conditions to Avoid: None known Hazardous Decomposition Products: Phosphorus oxides may form when heated to decomposition Under normal conditions of storage and use, hazardous decomposition products should not be produced. Hazardous Polymerization: Under normal conditions of storage and use, polymerization products should not be produced. XI. Toxicological Information United States Acute toxicity/Conclusion/Summary: To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity/Conclusion/Summary: Not available. Carcinogenicity/Conclusion/Summary: Not available. Mutagenicity/Conclusion/Summary: Not available. Teratogenicity/Conclusion/Summary: Not available. Reproductive toxicity/Summary: Not available Europe Acute Eye: Direct contact may cause irritation with redness Acute Skin: Direct contact may cause skin irritation with redness. Acute Inhalation: Acute and chronic exposure may cause irritation of the mucous membranes. Symptoms may include tightness and difficulty breathing. Acute ingestion: Acute exposure may cause gastrointestinal irritation to the mouth and stomach. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. V. Fire Fighting Measures Fire Hazard Data: Fire: This product is not considered to be a fire hazard. Auto-ignition: Unknown 20 Flash Point: Unknown Flammability Limits (vol/vol%): Unknown Lower: Unknown Upper: Unknown Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. Unusual Fire and Explosion Hazards: None VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. VII. Handling and Storage Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material refrigerated and in the dark. Keep container tightly sealed at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: Ingredient Name ACGIH NIOSH OSHA-PELs MES No occupational limits established 2-sulfobenzaldehyde No data available Engineering Controls: Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: 21 Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. IX. Physical and Chemical Properties Component: Conjugate Quench Reagent Physical Appearance: Clear colorless liquid Percent Purity: 1% Boiling Point: Not available Melting Point: Not available Specific gravity: Not available Freezing Point: Not Available Vapor pressure: Not available Vapor density: Not available Solubility: aqueous solutions Evaporation rate: Not available pH: 6.0 X. Stability and Reactivity Chemical Stability: This compound is considered stable under recommended storage and use conditions. Materials / Chemicals to Be Avoided: Aluminium, bases, iron, oxidants and phenol causing fire. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides (NOx) Hazardous Polymerization: Unknown XI. Toxicological Information United States Acute toxicity/Conclusion/Summary: To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. MES: No LD50/LC50 information found relating to normal routes of occupational exposure. 2-sulfobenzaldehyde: toxicological properties of this substance have not been fully investigated. Chronic toxicity/Conclusion/Summary: Not available. Carcinogenicity/Conclusion/Summary: 2-formylbenzensulfonic acid, sodium salt,- Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. Mutagenicity/Conclusion/Summary: Not available. Teratogenicity/Conclusion/Summary: Not available. Reproductive toxicity/Summary: Not available 22 XII. Ecological Information Acute Eye: Direct contact may cause irritation with redness Acute Skin: Direct contact may cause skin irritation with redness. Acute Inhalation: Acute and chronic exposure may cause irritation of the mucous membranes. Symptoms may include tightness and difficulty breathing. Acute ingestion: Acute exposure may cause gastrointestinal irritation to the mouth and stomach. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: 25 In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. V. Fire Fighting Measures Fire Hazard Data: Fire: This product is not considered to be a fire hazard. Auto-ignition: Unknown Flash Point: Unknown Flammability Limits (vol/vol%): Unknown Lower: Unknown Upper: Unknown Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. Unusual Fire and Explosion Hazards: None VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. VII. Handling and Storage Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material refrigerated. Keep container tightly sealed at 2-8oC. 26 VIII. Exposure Controls / Personal Protection Exposure Guidelines: Ingredient ACGIH NIOSH OSHA-PELs Name Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 dibasic PEL-STEL 3 mg/ m3 Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 monobasic PEL-STEL 3 mg/ m3 Sodium N/A chloride Engineering Controls: Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. IX. Physical and Chemical Properties Component: Bead Elution Buffer Physical Appearance: Clear colorless liquid Percent Purity: Not available Boiling Point: Not available Melting Point: Not available Specific gravity: Not available Freezing Point: Not Available Vapor pressure: Not available Vapor density: Not available Solubility: aqueous solutions Evaporation rate: Not available pH: 6.0 27 X. Stability and Reactivity Chemical Stability: This compound is considered stable. Conditions to Avoid: None known Hazardous Decomposition Products: Phosphorus oxides may form when heated to decomposition Under normal conditions of storage and use, hazardous decomposition products should not be produced. Hazardous Polymerization: Under normal conditions of storage and use, polymerization products should not be produced. XI. Toxicological Information United States Acute toxicity/Conclusion/Summary: To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity/Conclusion/Summary: Not available. Carcinogenicity/Conclusion/Summary: Not available. Mutagenicity/Conclusion/Summary: Not available. Teratogenicity/Conclusion/Summary: Not available. Reproductive toxicity/Summary: Not available Europe Acute Eye: Direct contact may cause irritation with redness Acute Skin: Direct contact may cause skin irritation with redness. Acute Inhalation: Acute and chronic exposure may cause irritation of the mucous membranes. Symptoms may include tightness and difficulty breathing. Acute ingestion: Acute exposure may cause gastrointestinal irritation to the mouth and stomach. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. V. Fire Fighting Measures Fire Hazard Data: Fire: This product is not considered to be a fire hazard. Auto-ignition: Unknown Flash Point: Unknown Flammability Limits (vol/vol%): Unknown Lower: Unknown Upper: Unknown Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. Unusual Fire and Explosion Hazards: In a fire or if heated, a pressure increase will occur and the container may burst. 32 VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. VII. Handling and Storage Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material refrigerated. Keep container tightly sealed at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: Ingredient ACGIH NIOSH OSHA-PELs Name Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 dibasic PEL-STEL 3 mg/ m3 Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 monobasic PEL-STEL 3 mg/ m3 Sodium N/A chloride Engineering Controls: Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: 33 Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. IX. Physical and Chemical Properties Component: Spin Column (Red Cap) Physical Appearance: White gel slurry in a sealed plastic housing Percent Purity: Not available Boiling Point: Not available Melting Point: Not available Specific gravity: 1.22 g/mL Freezing Point: Not Available Vapor pressure: Not available Vapor density: Not available Solubility: Easily dispersible in aqueous solutions Evaporation rate: Not available pH: 8.0 X. Stability and Reactivity Chemical Stability: This compound is considered stable. Conditions to Avoid: None known Hazardous Decomposition Products: Phosphorus oxides may form when heated to decomposition Under normal conditions of storage and use, hazardous decomposition products should not be produced. Hazardous Polymerization: Under normal conditions of storage and use, polymerization products should not be produced. XI. Toxicological Information United States Acute toxicity/Conclusion/Summary: To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity/Conclusion/Summary: Not available. Carcinogenicity/Conclusion/Summary: Not available. Mutagenicity/Conclusion/Summary: Not available. Teratogenicity/Conclusion/Summary: Not available. Reproductive toxicity/Summary: Not available Europe Acute Eye: Direct contact may cause irritation with redness Acute Skin: May cause moderate skin irritation. Acute Ingestion: Not considered a likely route of exposure under normal product use conditions. Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause effects similar to those of acute inhalation. Acute Inhalation: Effects may be delayed. May cause respiratory tract irritation. Chronic: May cause liver and kidney damage. May cause fetal effects. Repeated exposure may cause sensitization dermatitis. Chronic exposure may cause hemolysis of the red blood cells followed by stimulation of the bone marrow. Laboratory experiments have resulted in mutagenic effects. May cause cyanosis - a blue-gray coloring of the skin IV. First Aid Measures 38 First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. SEEK IMMEDIATE medical attention. Notes to Physician: Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. Cleansing of the entire contaminated area of the body is of utmost importance. Do not administer alcohol in any form. Individuals with liver or kidney disorders, impaired cardiovascular status, or a history of alcoholism may be more susceptible to the effects of this product. Effects may be delayed. If cyanosis is severe, intravenous injection of Methylene blue, 1mg/kg of body weight may be of value. Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia. V. Fire Fighting Measures Fire Hazard Data: Fire: This product is not considered to be a fire hazard when used as directed. Auto-ignition: Unknown Flash Point: Unknown Flammability Limits (vol/vol%): Unknown Lower: Unknown Upper: Unknown Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. Unusual Fire and Explosion Hazards: In a fire or if heated, a pressure increase will occur and sealed plastic container may burst. 39 VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. VII. Handling and Storage Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material refrigerated. Keep container tightly sealed at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: Ingredient Name ACGIH NIOSH OSHA-PELs Sodium phosphate, PEL-TWA Not listed PEL-TWA dibasic 1 mg/m3 PEL-STEL 3 mg/ m3 Sodium phosphate, PEL-TWA Not listed PEL-TWA monobasic 1 mg/m3 PEL-STEL 3 mg/ m3 Sodium chloride N/A Aniline TLV-TWA N/A PEL-TWA 2ppm 5ppm Engineering Controls: 40 Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. IX. Physical and Chemical Properties Component: Spin Column (Yellow Cap) Physical Appearance: White gel slurry in a sealed plastic housing Percent Purity: Not available Boiling Point: Not available Melting Point: Not available Specific gravity: Not available Freezing Point: Not Available Vapor pressure: Not available Vapor density: Not available Solubility: Easily dispersible in aqueous solutions Evaporation rate: Not available pH: 6.0 X. Stability and Reactivity Chemical Stability: This compound is considered stable. Conditions to Avoid: Temperatures <0oC or > 50oC Materials / Chemicals to Be Avoided: Reactive with strong oxidizing agents, metal, acids, alkali Hazardous Decomposition Products: Phosphorus oxides may form when heated to decomposition XI. Toxicological Information United States Information for Aniline Acute Eye: Direct contact may cause irritation with redness Acute Skin: Direct contact may cause skin irritation with redness. Acute Inhalation: Acute and chronic exposure may cause irritation of the mucous membranes. Symptoms may include tightness and difficulty breathing. Acute ingestion: Acute exposure may cause gastrointestinal irritation to the mouth and stomach. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. V. Fire Fighting Measures Fire Hazard Data: Fire: This product is not considered to be a fire hazard. 46 Auto-ignition: Unknown Flash Point: Unknown Flammability Limits (vol/vol%): Unknown Lower: Unknown Upper: Unknown Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. Unusual Fire and Explosion Hazards: In a fire or if heated, a pressure increase will occur and the container may burst. VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. VII. Handling and Storage Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material refrigerated. Keep container tightly sealed at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: Ingredient ACGIH NIOSH OSHA-PELs Name Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 dibasic PEL-STEL 3 mg/ m3 Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 monobasic PEL-STEL 47 3 mg/ m3 EDTA Not available Sodium azide Not available Engineering Controls: Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. IX. Physical and Chemical Properties Component: Spin Column (Blue Cap) Physical Appearance: White gel slurry in a sealed plastic housing Percent Purity: Not available Boiling Point: Not available Melting Point: Not available Specific gravity: Not available Freezing Point: Not Available Vapor pressure: Not available Vapor density: Not available Solubility: Easily dispersible in aqueous solutions Evaporation rate: Not available pH: 7.2 X. Stability and Reactivity Chemical Stability: Stable under recommended use conditions. Sodium azide reacts with lead and copper plumbing forming highly explosive metal azides. Conditions to Avoid: Avoid exposure to lead and copper. Hazardous Decomposition Products: Phosphorus oxides may form when heated to decomposition Under normal conditions of storage and use, hazardous decomposition products should not be produced. Hazardous Polymerization: Under normal conditions of storage and use, polymerization products should not be produced. XI. Toxicological Information United States 48 Acute toxicity/Conclusion/Summary: To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity/Conclusion/Summary: Not available. Carcinogenicity/Conclusion/Summary: Not available. Mutagenicity/Conclusion/Summary: Not available. Teratogenicity/Conclusion/Summary: Not available. Reproductive toxicity/Summary: Not available Europe Acute Eye: Direct contact causes irritation, redness and pain. May cause severe irritation and blurred vision. Acute Skin: Causes skin irritation with redness, itching, and pain. Can cause skin problems. Absorption can readily occur through the skin causing symptoms that parallel inhalation. Acute Inhalation: Exposure causes irritation to respiratory tract. of the mucous membranes. Symptoms may include coughing, shortness of breath, and difficulty breathing. May cause abdominal pain, loss of 52 appetite, nausea, weakness, dizziness, headache, constipation, vomiting, diarrhea, increased blood pressure anxiety, and palpitations. A flushing of the face and skin may occur, especially coincident with ingestion of alcoholic beverages Acute ingestion: Ingestion causes gastrointestinal irritation. Symptoms parallel inhalation. Fatal dose estimated at 10 grams. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: Immediately flush eyes with copious amounts of water for at least 15 minutes. Lift upper and lower eyelids occasionally. GET MEDICAL ATTENTION. develops seek medical attention. Skin Exposure: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. GET MEDICAL ATTENTION. Inhalation Exposure: Move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. GET MEDICAL ATTENTION. V. Fire Fighting Measures Fire Hazard Data: Fire: Material is considered flammable. Autoignition: 445 oC (833 oF) Flash Point: 58oC (136oF) Flammability Limits (vol/vol%): Lower: 2.2 Upper: 15.2 Extinguishing Media: Use dry chemical, alcohol foam or carbon dioxide Special Fire Fighting Procedures: In the event of a fire wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. Water spray may be used to extinguish surrounding fire and cool exposed containers. Water spray will also reduce fume and irritant gas. VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. 53 VII. Handling and Storage Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material either refrigerated or at room temperature. Keep container tightly sealed at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: DMF or N, N-dimethylformamide ACGIH (United States, 0/2000). Skin TWA: 10 ppm Acute Eye: Direct contact may cause irritation with redness Acute Skin: Direct contact may cause skin irritation with redness. Acute Inhalation: Acute and chronic exposure may cause irritation of the mucous membranes. Symptoms may include tightness and difficulty breathing. Acute ingestion: Acute exposure may cause gastrointestinal irritation to the mouth and stomach. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. 59 Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. V. Fire Fighting Measures Fire Hazard Data: Fire: This product is not considered to be a fire hazard. Auto-ignition: Unknown Flash Point: Unknown Flammability Limits (vol/vol%): Unknown Lower: Unknown Upper: Unknown Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. Unusual Fire and Explosion Hazards: None VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. VII. Handling and Storage Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material refrigerated and in the dark. Keep container tightly sealed at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: 60 Ingredient Name ACGIH NIOSH OSHA-PELs 2-hydrazinopyridine No dihydrochloride occupational limits established MES No occupational limits established Engineering Controls: Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. IX. Physical and Chemical Properties Component: 2-HP Reagent Physical Appearance: Clear colorless liquid Percent Purity: 0.009% Boiling Point: Not available Melting Point: Not available Specific gravity: Not available Freezing Point: Not Available Vapor pressure: Not available Vapor density: Not available Solubility: aqueous solutions Evaporation rate: Not available pH: 6.0 X. Stability and Reactivity Chemical Stability: This compound is considered stable under recommended storage conditions. Materials / Chemicals to Be Avoided: Strong oxidizing agents, Strong acids, Acid chlorides, Acid anhydrides Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides (NOx) Hazardous Polymerization: Unknown XI. Toxicological Information 61 United States Acute toxicity/Conclusion/Summary: To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity/Conclusion/Summary: Not available. Carcinogenicity/Conclusion/Summary: Not available. Mutagenicity/Conclusion/Summary: Not available. Teratogenicity/Conclusion/Summary: Not available. Reproductive toxicity/Summary: Not available XII. Ecological Information Acute Eye: Direct contact may cause irritation with redness Acute Skin: Direct contact may cause skin irritation with redness. Acute Inhalation: Acute and chronic exposure may cause irritation of the mucous membranes. Symptoms may include tightness and difficulty breathing. Acute ingestion: Acute exposure may cause gastrointestinal irritation to the mouth and stomach. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. V. Fire Fighting Measures Fire Hazard Data: Autoignition temp: 789 oC Flash point: 36 oC (closed cup) Specific gravity: 0.989 g/cm3 Autoignition temp: 789 oC Flash point: 36 oC (closed cup) Vapor pressure: 43.6 mmHg (ethanol) Vapor density: 1.52 g/l (ethanol) Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. 65 Unusual Fire and Explosion Hazards: None VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. VII. Handling and Storage Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material refrigerated. Keep container tightly sealed at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: Ingredient ACGIH NIOSH OSHA-PELs Name Ethanol 1900 mg/m3 Not available TWA: 1000 ppm 8 hour(s). Agarose media Not available Iron oxide 5 mg/M3 TWA Not available 10 ppm (Iron (II,III) Oxide Fume as Fe) Engineering Controls: Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. 66 IX. Physical and Chemical Properties Component: Affinity Magnetic Beads Physical Appearance Black slurry suspension; color colorless liquid, black suspension Odor: slightly alcohol-like Boiling Point: 77-78oC (ethanol) Melting Point: May solidify at <0 oC Autoignition temp: 789 oC Flash point: 36 oC (closed cup) Specific gravity: 0.989 g/cm3 Autoignition temp: 789 oC Flash point: 36 oC (closed cup) Vapor pressure: 43.6 mmHg (ethanol) Vapor density: 1.52 g/l (ethanol) X. Stability and Reactivity Chemical Stability: Stable. The product is stable under normal use conditions. Conditions to Avoid: Heat and flame. Materials / Chemicals to Be Avoided: Exposure to oxidizing agents such as hydrogen peroxide, perchloric acid; nitric acid; metal perchlorates, metal nitrates, sodium metals, potassium metals, acid anhydrides, acid chlorides Hazardous Decomposition Products: Carbon monoxide, carbon dioxide Hazardous Polymerization: Unknown XI. Toxicological Information United States Acute toxicity/Conclusion/Summary: To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity/Conclusion/Summary: Not available. Carcinogenicity/Conclusion/Summary: Not available. Mutagenicity/Conclusion/Summary: Not available. Teratogenicity/Conclusion/Summary: Not available. Reproductive toxicity/Summary: Not available Europe Acute Eye: Unknown. Avoid contact or exposure to eyes. Acute Skin: Unknown. Avoid contact or exposure to skin. Acute Inhalation: Unknown. Avoid contact or exposure to skin. 70 Acute ingestion: Unknown. Avoid ingestion. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. V. Fire Fighting Measures Fire Hazard Data: Fire: This product is not considered to be a fire hazard. Auto-ignition: Unknown Flash Point: Unknown Flammability Limits (vol/vol%): Unknown Lower: Unknown Upper: Unknown Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. Unusual Fire and Explosion Hazards: None VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. 71 VII. Handling and Storage Handling/Storage: Do not breathe dust. Do not get into eyes, skin or clothing. Avoid prolonged or repeated exposure. Handle wearing gloves. Store material dry and keep refrigerated. Keep container tightly sealed in re-sealable aluminum pouch containing dessicant at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: Ingredient ACGIH NIOSH OSHA-PELs Name S-4FB No occupational limits established Engineering Controls: Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. IX. Physical and Chemical Properties Component: S-4FB Physical Appearance: White powder Percent Purity: >90% Boiling Point: Not available Melting Point: Not available Specific gravity: Not available Freezing Point: Not Available Vapor pressure: Not available Vapor density: Not available Solubility: soluble in aqueous as well as DMF and DMSO solvents Evaporation rate: Not available 72 X. Stability and Reactivity Chemical Stability: This compound is considered stable. Conditions to Avoid: Susceptible to aqueous hydrolysis, avoid exposure to aqueous solutions before use. Materials/Chemicals to Be Avoided: Aromatic aldehydes decompose on exposure to reducing agents Hazardous Decomposition Products: Carbon monoxide, carbon dioxide in case of fire. Under normal conditions of storage and use, hazardous decomposition products should not be produced. Hazardous Polymerization: Under normal conditions of storage and use, polymerization products should not be produced. XI. Toxicological Information United States Acute toxicity/Conclusion/Summary: To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity/Conclusion/Summary: Not available. Carcinogenicity/Conclusion/Summary: Not available. Mutagenicity/Conclusion/Summary: Not available. Teratogenicity/Conclusion/Summary: Not available. Reproductive toxicity/Summary: Not available Europe Acute Eye: Direct contact may cause irritation with redness Acute Skin: Direct contact may cause skin irritation with redness. Acute Inhalation: Acute and chronic exposure may cause irritation of the mucous membranes. Symptoms may include tightness and difficulty breathing. Acute ingestion: Acute exposure may cause gastrointestinal irritation to the mouth and stomach. IV. First Aid Measures 76 First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or induce vomiting if the victim is unconscious or having convulsions. V. Fire Fighting Measures Fire Hazard Data: Fire: This product is not considered to be a fire hazard. Auto-ignition: Unknown Flash Point: Unknown Flammability Limits (vol/vol%): Unknown Lower: Unknown Upper: Unknown Extinguishing Media: Use extinguishing media appropriate for surrounding fire Special Fire Fighting Procedures: Use extinguishing media appropriate for surrounding fire such as water spray, carbon dioxide, dry powder. Wear full protective clothing and NIOSH- approved self-contained breathing apparatus. Avoid inhalation of material or combustion by- products. Unusual Fire and Explosion Hazards: In a fire or if heated, a pressure increase will occur and the container may burst. VI. Accidental Release Measures Cleanup and Disposal of Spill: Use lab personal protective equipment such as gloves, lab coat, goggles and self-contained breathing apparatus. Wipe spills with absorbent wipes and discard any product, residue, disposable container or liner in full compliance with national or international regulations. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. VII. Handling and Storage 77 Handling/Storage: Do not get into eyes, skin or clothing. Handle wearing gloves. Store material refrigerated. Keep container tightly sealed at 2-8oC. VIII. Exposure Controls / Personal Protection Exposure Guidelines: Ingredient ACGIH NIOSH OSHA-PELs Name Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 dibasic PEL-STEL 3 mg/ m3 Sodium PEL-TWA Not listed PEL-TWA phosphate, 1 mg/m3 monobasic PEL-STEL 3 mg/ m3 Engineering Controls: Ventilation must be adequate to maintain the ambient workplace atmosphere below the exposure limit(s) outlined in the MSDS. General room ventilation is satisfactory under anticipated use conditions. Respiratory Protection: Not required under anticipated use conditions. Eye / Face Protection: Wear appropriate safety glasses with side shields or chemical goggles as described by OSHA’s eye and face protection regulations in 29CFR 1910.133 or European Standard EN166. Skin Protection: Wear chemical resistant gloves (such as latex or neoprene) and protective clothing to prevent skin contact. IX. Physical and Chemical Properties Component: Spin Column (Brown Cap) Physical Appearance: White gel slurry in a sealed plastic housing Percent Purity: Not available Boiling Point: Not available Melting Point: Not available Specific gravity: Not available Freezing Point: Not Available Vapor pressure: Not available Vapor density: Not available Solubility: Easily dispersible in aqueous solutions Evaporation rate: Not available pH: 6.0 78 X. Stability and Reactivity Chemical Stability: Stable under recommended use conditions. Conditions to Avoid: Avoid exposure to lead and copper. Hazardous Decomposition Products: Phosphorus oxides may form when heated to decomposition Under normal conditions of storage and use, hazardous decomposition products should not be produced. Hazardous Polymerization: Under normal conditions of storage and use, polymerization products should not be produced. XI. Toxicological Information United States Acute toxicity/Conclusion/Summary: To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Chronic toxicity/Conclusion/Summary: Not available. Carcinogenicity/Conclusion/Summary: Not available. Mutagenicity/Conclusion/Summary: Not available. Teratogenicity/Conclusion/Summary: Not available. Reproductive toxicity/Summary: Not available Europe

Potential chronic health

No known significant effects or critical hazards Carcinogenicity: No known significant effects or critical hazards. Mutagenicity: No known significant effects or critical hazards. No known significant effects or critical hazards Carcinogenicity: No known significant effects or critical hazards. Mutagenicity: No known significant effects or critical hazards. No known significant effects or critical hazards Carcinogenicity: No known significant effects or critical hazards. Mutagenicity: No known significant effects or critical hazards. No known significant effects or critical hazards Carcinogenicity: No known significant effects or critical hazards. Mutagenicity: No known significant effects or critical hazards. No known significant effects or critical hazards Carcinogenicity: No known significant effects or critical hazards. Mutagenicity: No known significant effects or critical hazards. No known significant effects or critical hazards Carcinogenicity: No known significant effects or critical hazards. Mutagenicity: No known significant effects or critical hazards. No known significant effects or critical hazards Carcinogenicity: No known significant effects or critical hazards. Mutagenicity: No known significant effects or critical hazards.

Teratogenic Effects

No known significant effects or critical hazards Developmental effects: No known significant effects or critical hazards. Fertility effects: No known significant effects or critical hazards. XII. Ecological Information 16 No known significant effects or critical hazards Developmental effects: No known significant effects or critical hazards. Fertility effects: No known significant effects or critical hazards. XII. Ecological Information No known significant effects or critical hazards Developmental effects: No known significant effects or critical hazards. Fertility effects: No known significant effects or critical hazards. 34 XII. Ecological Information No known significant effects or critical hazards Developmental effects: No known significant effects or critical hazards. Fertility effects: No known significant effects or critical hazards. XII. Ecological Information No information available Reproductive effects: Similar compounds have shown reproductive effects. Neurotoxicity: No information available. LD50/LC50 for CAS # 68-12-2 Acute Oral Toxicity:LD50 rat, LD50 = 2800 mg/kg Acute Inhalation Toxicity: rat LC50 = 3421 ppm/1H Skin toxicity: LD50 rabbit 4.72 g/kg . XII. Ecological Information No known significant effects or critical hazards Developmental effects: No known significant effects or critical hazards. 67 Fertility effects: No known significant effects or critical hazards. XII. Ecological Information No known significant effects or critical hazards Developmental effects: No known significant effects or critical hazards. Fertility effects: No known significant effects or critical hazards. XII. Ecological Information No known significant effects or critical hazards Developmental effects: No known significant effects or critical hazards. Fertility effects: No known significant effects or critical hazards. XII. Ecological Information

Environmental effects

No known significant effects or critical hazards. Leaches through the soil or sediment at a moderate rate. Accumulates very little in bodies of living organisms. Aquatic ecotoxicity/Conclusion/Summary: None known. No data available Aquatic ecotoxicity/Conclusion/Summary: No data available. No known significant effects or critical hazards. Leaches through the soil or sediment at a moderate rate. Accumulates very little in bodies of living organisms. Aquatic ecotoxicity/Conclusion/Summary: None known. No known significant effects or critical hazards. Leaches through the soil or sediment at a moderate rate. Accumulates very little in bodies of living organisms. Aquatic ecotoxicity/Conclusion/Summary: None known. Not available Aquatic ecotoxicity/Conclusion/Summary: None known. No known significant effects or critical hazards. Leaches through the soil or sediment at a moderate rate. Accumulates very little in bodies of living organisms. Aquatic ecotoxicity/Conclusion/Summary: None known. When released into soil or water this material is expected to readily biodegrade and is not expected to bioaccumulate. When released into the air, this material is expected to degrade by photochemical reaction to produce hydroxyl radicals. Persistence/degradability Bioaccumulative potential VCI WGK: No products were found. Ecotoxicity data 55 Persistence/degradability: No data available Bioaccumulative potential: No data available Other ecological information: No data available Aquatic ecotoxicity/Conclusion/Summary: DMF Daphnia magna (EC50) Blue Gill (LC50) Trout (LC50) Minnows (LC50) 9600 to 13100 mg/l 6700 to 7500 mg/l 9000 to 13000 mg/l 10400 to 10800 mg/l No data available Aquatic ecotoxicity/Conclusion/Summary: No data available. No known significant effects or critical hazards. Leaches through the soil or sediment at a moderate rate. Accumulates very little in bodies of living organisms. Aquatic ecotoxicity/Conclusion/Summary: None known. Not available Aquatic ecotoxicity/Conclusion/Summary: Not available. No known significant effects or critical hazards. Leaches through the soil or sediment at a moderate rate. Accumulates very little in bodies of living organisms. Aquatic ecotoxicity/Conclusion/Summary: None known.

Other hazards

No known significant effects or critical hazards XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. These regulations apply to discharges of this substance. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Not regulated UN #: not regulated No data available XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Ethylenediaminetetraacetic acid is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act. These regulations apply to discharges of this substance. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Not regulated UN #: not regulated No known significant effects or critical hazards XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. These regulations apply to discharges of this substance. 28 Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Not regulated UN #: not regulated No known significant effects or critical hazards XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. These regulations apply to discharges of this substance. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Not regulated UN #: not regulated No known significant effects or critical hazards XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. These regulations apply to discharges of this substance. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. XIV. Transportation Information DOT Proper Shipping Name: Aniline UN #: 1547 42 Packaging Group: II Hazard Label Statement: - Aqueous solutions containing 1% or less aniline by volume is not subject to these regulations. IATA IATA Special Provision - Aqueous solutions containing 1% or less aniline by volume is not subject to these regulations. XV. Regulatory Information United States No known significant effects or critical hazards XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. These regulations apply to discharges of this substance. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Not regulated 49 UN #: not regulated No known significant effects or critical hazards XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. These regulations apply to discharges of this substance. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Not regulated in small quantities UN #: not regulated in small quantities No data available XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Ethylenediaminetetraacetic acid is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act. These regulations apply to discharges of this substance. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Not regulated UN #: not regulated No known significant effects or critical hazards XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. These regulations apply to discharges of this substance. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Combustible liquid, n.o.s. UN #: 1193 Not available XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7 HANDLING AND STORAGE and Section 8 EXPOSURE 73 CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Not regulated UN #: not regulated No known significant effects or critical hazards XIII. Disposal Considerations Waste Disposal: The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal 79 of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. These regulations apply to discharges of this substance. Disposal should be in accordance with applicable regional, national and local laws and regulations.Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. XIV. Transportation Information DOT Proper Shipping Name: Not regulated UN #: not regulated

Hazard categories

not regulated Packaging Group: Not regulated Label Statement: Not regulated IATA Proper Shipping Name: Not regulated IATA UN Number: Not regulated Not regulated Packaging Group: Not regulated XV. Regulatory Information United States not regulated Packaging Group: Not regulated Label Statement: Not regulated IATA Proper Shipping Name: Not regulated IATA UN Number: Not regulated Not regulated Packaging Group: Not regulated XV. Regulatory Information United States U.S. Federal regulations: United States inventory (TSCA 8b): All components are listed or exempted. SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: No products were found. SARA 311/312 –No SARA hazards. 23 EU Regulations Not classified XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined ACGIH – American Conference of Governmental Industrial Hygienists not regulated Packaging Group: Not regulated Label Statement: Not regulated IATA Proper Shipping Name: Not regulated IATA UN Number: Not regulated Not regulated Packaging Group: Not regulated XV. Regulatory Information United States not regulated Packaging Group: Not regulated Label Statement: Not regulated IATA Proper Shipping Name: Not regulated IATA UN Number: Not regulated Not regulated Packaging Group: Not regulated XV. Regulatory Information United States 35 not regulated Packaging Group: Not regulated Label Statement: Not regulated IATA Proper Shipping Name: Not regulated IATA UN Number: Not regulated Not regulated Packaging Group: Not regulated XV. Regulatory Information United States not regulated in small quantities Packaging Group: Not regulated in small quantities Label Statement: Not regulated in small quantities IATA Proper Shipping Name: Not regulated in small quantities IATA UN Number: Not regulated in small quantities Not regulated in small quantities Packaging Group: Not regulated in small quantities XV. Regulatory Information United States 56 U.S. Federal regulations: not regulated Packaging Group: Not regulated Label Statement: Not regulated IATA Proper Shipping Name: Not regulated IATA UN Number: Not regulated Not regulated Packaging Group: Not regulated XV. Regulatory Information 62 United States U.S. Federal regulations: United States inventory (TSCA 8b): All components are listed or exempted. SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: No products were found. SARA 311/312 –No SARA hazards. EU Regulations Not classified XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined ACGIH – American Conference of Governmental Industrial Hygienists Flammable Packaging Group: Group III Hazard Label Statement: None PIH: None PIH IATA Non-hazardous for air transport XV. Regulatory Information United States U.S. Federal regulations: United States inventory (TSCA 8b): Ethanol SARA 302/304/311/312 extremely hazardous substances: No products were found. 68 SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: ethanol SARA 311/312 MSDS distribution - chemical inventory - hazard identification ethanol fire hazard (acute) health hazard, delayed (chronic) health hazard Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: This product is listed. Clean Air Act (CAA) 112 accidental release prevention: No products were found. Clean Air Act (CAA) 112 regulated flammable substances: No products were found. Clean Air Act (CAA) 112 regulated toxic substances: No products were found. EU Regulations not regulated Packaging Group: Not regulated Label Statement: Not regulated IATA Proper Shipping Name: Not regulated IATA UN Number: Not regulated Not regulated Packaging Group: Not regulated XV. Regulatory Information United States U.S. Federal regulations: United States inventory (TSCA 8b): All components are listed or exempted. SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: No products were found. SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found. Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: No products were found. Clean Air Act (CAA) 112 accidental release prevention: No products were found. Clean Air Act (CAA) 112 regulated flammable substances: No products were found. Clean Air Act (CAA) 112 regulated toxic substances: No products were found. Canada not regulated Packaging Group: Not regulated Label Statement: Not regulated IATA Proper Shipping Name: Not regulated IATA UN Number: Not regulated Not regulated Packaging Group: Not regulated XV. Regulatory Information United States

2.1 Classification of the substance or mixture

30 Solulink-858.625.0670 II. Chemical Composition Component Name: Spin Column (Red Cap) Physical appearance: liquid slurry gel Chemical composition: Spin Column (Red Cap) contains a polymeric chromatography resin (slurry) equilibrated in sodium phosphate/sodium chloride solution pH 8.0 Ingredient Name CAS % EC number Classification Number Sodium phosphate, 10049-21-5 < 1% 231-449-2 Xi, R 36/37/38 monobasic Sodium phosphate, 7558-79-4 < 1% 231-448-7 Xi, R 36/37/38 dibasic Sodium chloride 7647-14-5 < 1% 231-598-3 Xi, R 36/37/38 Polymeric resin Not available 50% Not available Water 07732-18-5 47.63 N/A Not controlled III. Hazards Identification OSHA/HSC Status: While this material is not considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200), this MSDS contains valuable information critical to the safe handling and proper use of the product. This MSDS should be retained and available for employees and other users of this product. The preparation is not classified as dangerous according to Directive 1999/45/EC and its amendments. Emergency Overview and Health Hazards: NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. HMIS Rating (Scale 0-4): Health = 1 Fire =1 Reactivity = 0 A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid 31 B. Potential Health Effects: Acute Eye: Direct contact may cause irritation with redness Acute Skin: Direct contact may cause skin irritation with redness. Acute Inhalation: Acute and chronic exposure may cause irritation of the mucous membranes. Symptoms may include tightness and difficulty breathing. Acute ingestion: Acute exposure may cause gastrointestinal irritation to the mouth and stomach. IV. First Aid Measures First Aid Measures for Accidental Exposure: Eye Exposure: In case of contact with eyes, immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating eye lids. Skin Exposure: In case of skin contact, wash affected areas with soap and water and flush the area with copious amounts of water. Remove contaminated clothing. Inhalation Exposure: In inhaled, move to fresh air. If not breathing, administer artificial respiration. If breathing is difficult, give oxygen or artificial respiration by qualified personnel. Ingestion Exposure: If swallowed, rinse mouth out with water provided person is conscious. Never give fluids or

EC Classification

Xi -irritant Xi -irritant T Toxic, Xi –irritant Xi = Irritant T+ = Toxic Xi -irritant T -toxic R11, highly flammable, Xi -irritant Xi = Irritant T+ = Toxic

Hazard statements

R36 irritating to eyes R37 irritating to respiratory system R38 irritating to skin International Regulations International Lists: Australia inventory (AICS): All components are listed or exempted. China inventory (IECSC): All components are listed or exempted. Korea inventory (KECI): All components are listed or exempted. Philippines inventory (PICCS): All components are listed or exempted. Japan inventory (ENCS): All components are listed or exempted. XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined ACGIH – American Conference of Governmental Industrial Hygienists R36 irritating to eyes R37 irritating to respiratory system R38 irritating to skin International Regulations International Lists: Australia inventory (AICS): All components are listed or exempted. China inventory (IECSC): All components are listed or exempted. Korea inventory (KECI): All components are listed or exempted. Philippines inventory (PICCS): All components are listed or exempted. Japan inventory (ENCS): All components are listed or exempted. XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined ACGIH – American Conference of Governmental Industrial Hygienists R2: Keep out of reach of children R36 irritating to eyes R23 Toxic by inhalation R24 Toxic in contact with skin R25 Toxic if swallowed R37 irritating to respiratory system R38 irritating to skin International Regulations Australian Hazchem Code: 3X XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined ACGIH – American Conference of Governmental Industrial Hygienists R22 Harmful if swallowed. R36 Irritating to eyes R37 Irritating to respiratory system R38 Irritating to skin R50 Very toxic to aquatic organisms. R51 Toxic to aquatic organisms. R52 Harmful to aquatic organisms. R53 May cause long-term adverse effects in the aquatic environment. R20 Harmful by inhalation R21 Harmful by contact with skin R36 Irritating to eyes R61 May cause harm to unborn child R51 Avoid exposure - obtain special instructions before use. R11-highly flammable R36 irritating to eyes R37 irritating to respiratory system R38 irritating to skin XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined ACGIH – American Conference of Governmental Industrial Hygienists R22 Harmful if swallowed. R36 Irritating to eyes R37 Irritating to respiratory system R38 Irritating to skin R50 Very toxic to aquatic organisms. R51 Toxic to aquatic organisms. R52 Harmful to aquatic organisms. R53 May cause long-term adverse effects in the aquatic environment.

NFPA Ratings

Scale 0-4) Health = 1 Fire = 1 Reactivity = 0 NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN 19 THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid (Scale 0-4) Health = 2 Fire = 0 Reactivity = 1 Emergency Overview and Health Hazards: NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. (Scale 0-4) Health = 2 Fire = 0 Reactivity = 1 A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid (Scale 0-4) Health = 2 Fire = 2 Reactivity = 0 Contact rating = 3 Emergency Overview and Health Hazards: A. Emergency Overview: (Scale 0-4) Health = unknown Fire = unknown Reactivity = unknown

Health hazards

Under normal use conditions, product as manufactured is not anticipated to cause major health hazards. May cause skin, eye and respiratory irritation from accidental exposure. Respiratory tract irritation. Skin and eye irritation Warning, harmful if swallowed, inhaled or absorbed through skin. Causes irritation to skin, eyes, and respiratory tract. Toxic to liver. Affects kidneys, cardiovascular system and central nervous system. Causes alcohol intolerance and skin problems. Respiratory tract irritation. Skin and eye irritation

Principle Routes of Exposure

Inhalation, ingestion and skin absorption Skin absorption: toxic if absorbed through skin. Readily absorbed through skin. Eye contact: causes severe eye irritation. Ingestion: toxic if swallowed Inhalation: Material is irritating to mucous membranes and upper respiratory tract. Toxic if inhaled. Sensitization; 41 Skin: May cause allergic skin reaction. Target Organs: Blood, bladder, kidneys, central nervous system. Signs and symptoms of exposure: Fatigue. Incoordination. Nausea. Vomiting. Headache. Dizziness. Symptoms may be delayed. Unconsciousness. Weakness. Confusion.Drowuiness. Absorption into body leads to methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2-4 hours. Carcinogenicity: ACGIH:Classified A3 (proven for animal) IARC: (not classifiable for human)

Physical hazards

None Flammable liquid and vapor None

Precautionary statements

S23 Keep out of reach of children S24 Avoid skin contact. 50 S25 Avoid contact with eyes S26 In case of contact with eyes, rinse immediately with water and seek medical advice S46 If swallowed, see medical advice immediately and show this MSDS XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined ACGIH – American Conference of Governmental Industrial Hygienists S53 Avoid exposure and obtain special instructions before use. S45 In case of accident or if you feel unwell; seek medical advice, show this label XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined 57 ACGIH – American Conference of Governmental Industrial Hygienists S23 Keep out of reach of children S24 Avoid skin contact. S25 Avoid contact with eyes S26 In case of contact with eyes, rinse immediately with water and seek medical advice S46 If swallowed, see medical advice immediately and show this MSDS XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined ACGIH – American Conference of Governmental Industrial Hygienists

Other hazards which do not result in classification

Rapidly absorbed through skin. Physical Appearance: Clear colorless liquid

Other physicochemical hazards

Highly Flammable Ingredient Ethanol: HMIS Rating (Scale 0-4): Health = 1 Fire= 3 Reactivity = 0 Protection: See section 8 Emergency Overview and Health Hazards: NOT EXPECTED TO PRODUCE SIGNIFICANT ADVERSE HEALTH EFFECTS WHEN THE RECOMMENDED INSTRUCTIONS FOR USE ARE FOLLOWED. A. Emergency Overview: Information Pertaining To Particular Dangers for Man and Environment: This reagent is not considered hazardous when recommend instructions are used. No known significant effects or critical hazards. Avoid prolonged contact with eyes, skin and clothing. Always use appropriate personal protective equipment. Physical Appearance: Clear, colorless aqueous liquid 64

EU Classification

This product is not classified according to EU legislation XVI. Other Information Key Legend Information: N/A – Not Applicable ND – Not Determined ACGIH – American Conference of Governmental Industrial Hygienists