Palbociclib

Hazard statements (CLP)

H341, H361f, H373, H411

Code

Statements

H341

Suspected of causing genetic defects

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Germ cell mutagenicity, H341: Suspected of causing genetic (Category 2) defects. Reproductive toxicity, (Category H361f: Suspected of damaging fertility. 2) Specific target organ toxicity - H373: May cause damage to organs repeated exposure, (Category 2), through prolonged or repeated exposure if Bone marrow, male reproductive swallowed. organs Long-term (chronic) aquatic H411: Toxic to aquatic life with long lasting hazard, (Category 2) effects.

2.2 Label elements

Labelling

Signal word

Warning Warning

Hazard statements

H341 Suspected of causing genetic defects. H361f Suspected of damaging fertility. H373 May cause damage to organs (Bone marrow, male reproductive organs) through prolonged or repeated exposure if swallowed. H411 Toxic to aquatic life with long lasting effects. Reduced Labeling (<= 125 ml) H341 Suspected of causing genetic defects. H361f Suspected of damaging fertility.

Precautionary statements

P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 IF exposed or concerned: Get medical advice/ attention.

Supplemental label elements

none none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

ECOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

TOXICOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.