Selumetinib

Hazard statements (CLP)

H302, H317, H361f, H373, H413

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

Regulation (EC) No. 1272/2008 Classification of the substance or mixture Acute toxicity, (Category 4) H302: Harmful if swallowed Skin sensitization, (Category H317: May cause an allergic skin reaction Reproductive toxicity, (Category H361f: Suspected of damaging fertility. 2) Specific target organ toxicity H373: May cause damage to organs repeated exposure, (Category 2), through prolonged or repeated exposure. Gastrointestinal tract, Eyes, Urinary tract Long-term (chronic) aquatic H413: May cause long lasting harmful hazard, (Category 4) effects to aquatic life.

Signal word

Warning Warning

Hazard statements

H302 Harmful if swallowed. H317 May cause an allergic skin reaction. H361f Suspected of damaging fertility. H373 May cause damage to organs (Gastrointestinal tract, Eyes, Urinary tract) through prolonged or repeated exposure. H413 May cause long lasting harmful effects to aquatic life. H317 May cause an allergic skin reaction. H413 May cause long lasting harmful effects to aquatic life. H361f Suspected of damaging fertility.

Precautionary statements

P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of water. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of water. P308 + P313 IF exposed or concerned: Get medical advice/ attention.

Supplemental label elements

none Reduced Labeling (<= 125 ml) none

Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher

ECOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

TOXICOLOGICAL INFORMATION

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

2.1 Classification of the substance or mixture

Acute toxicity, (Category 4) H302: Harmful if swallowed. Skin sensitization, (Category 1) H317: May cause an allergic skin reaction. Reproductive toxicity, (Category H361f: Suspected of damaging fertility. 2) Specific target organ toxicity - H373: May cause damage to organs repeated exposure, (Category 2), through prolonged or repeated exposure. Gastrointestinal tract, Eyes, Urinary tract Long-term (chronic) aquatic H413: May cause long lasting harmful hazard, (Category 4) effects to aquatic life.