Note: Ingredients listed on restricted chemical lists
EC/CAS
200-413-8
Name of the chemical
Methotrexate (INN)
Concentration
>=70-<90 >=10-<20
General Information
Version
7.0
Revision date
2024-03-15
Product name
Methotrexate System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard
REACH No
This
1.2.2. Uses advised against
For R&D use only. Not for pharmaceutical, household or other uses
Emergency telephone
800-424-9300, +1-703- 527-3887
Icons in SDS
Company Information
company name
Sigma-Aldrich Inc
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H301, H315, H319, H341, H360D, H372
Hazard statements
Code
Statements
H301
Toxic if swallowed
Section 2
SECTION 2: Hazards identification
Regulation (EC) No. 1272/2008 Classification of the substance or mixture Acute toxicity, (Category 3) H301: Toxic if swallowed Skin irritation, (Category 2) H315: Causes skin irritation Eye irritation, (Category 2) H319: Causes serious eye irritation Germ cell mutagenicity, H341: Suspected of causing genetic Category 2) defects Reproductive toxicity, (Category H360D: May damage the unborn child. 1B) Specific target organ toxicity H372: Causes damage to organs through repeated exposure, (Category 1), prolonged or repeated exposure. Liver, Bone marrow
Signal word
Danger Danger
Hazard statements
H301 Toxic if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H341 Suspected of causing genetic defects. H360D May damage the unborn child. H372 Causes damage to organs (Liver, Bone marrow) through prolonged or repeated exposure. H301 Toxic if swallowed. H341 Suspected of causing genetic defects. H372 Causes damage to organs through prolonged or repeated exposure. H360D May damage the unborn child.
Precautionary statements
P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust. P264 Wash skin thoroughly after handling. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P302 + P352 IF ON SKIN: Wash with plenty of water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust. P264 Wash skin thoroughly after handling. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
Supplemental label elements
none Reduced Labeling (<= 125 ml) none
Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher
ECOLOGICAL INFORMATION
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
TOXICOLOGICAL INFORMATION
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
2.1 Classification of the substance or mixture
Acute toxicity, (Category 3) H301: Toxic if swallowed. Skin irritation, (Category 2) H315: Causes skin irritation. Eye irritation, (Category 2) H319: Causes serious eye irritation. Germ cell mutagenicity, H341: Suspected of causing genetic (Category 2) defects. Reproductive toxicity, (Category H360D: May damage the unborn child. 1B) Specific target organ toxicity - H372: Causes damage to organs through repeated exposure, (Category 1), prolonged or repeated exposure. Liver, Bone marrow
