Decitabine for Injection

Signal word

DANGER! GHS Class: Acute toxicity - Oral, Category 4 Acute toxicity - Dermal, Category 4 Acute toxicity - Inhalation, Category 4 Skin irritation, Category 2 Eye irritation, Category 2A Germ cell mutagenicity, Category 2 Reproductive toxicity, Category 1B Specific target organ toxicity - single exposure, Category 3 (Respiratory system)

Hazard statements

Harmful if inhaled. May cause respiratory irritation. Suspected of causing genetic defects. May damage fertility or the unborn child. Causes serious eye and skin irritation. Harmful if swallowed or if inhaled Harmful in contact with skin or if inhaled

Precautionary statements

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash hands thoroughly after handling. IF exposed or concerned: Get medical advice/attention. Store locked up. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Store in a well-ventilated place. Keep container tightly closed. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Use only outdoors or in a well-ventilated area. Dispose of contents/container in accordance with Local, State, Federal and Provincial regulations. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash it before reuse. Emergency Overview: This product is intended for therapeutic use only when prescribed by a physician. Potential adverse reactions from prescribed doses and overdoses are described in the package insert.

Principle Routes of Exposure

Inhalation Ingestion Eye contact Skin Absorption. Injection.

Potential health effects

Eye: Contact with eyes may cause irritation. Skin: May cause skin irritation. Inhalation: May cause irritation of respiratory tract. Ingestion: May cause irritation. Signs/Symptoms: There is no known antidote for overdosage with decitabine for injection. Higher doses are associated with increased myelosuppression including prolonged neutropenia and thrombocytopenia. Standard supportive measures should be taken in the event of an overdose.