Hydrochloric acid

Hazard statements (CLP)

H226, H312, H312+H332, H319, H332, H360D

Code

Statements

H226

Flammable liquid and vapour

SECTION 2: Hazards identification

Classification of the substance or mixture

Signal word

Danger

Hazard statements

H226 Flammable liquid and vapour. H312 + H332 Harmful in contact with skin or if inhaled H319 Causes serious eye irritation. H360D May damage the unborn child. Sigma - D4551 Page 1 of 8 340

Precautionary statements

P201 Obtain special instructions before use. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face P308 + P313 IF exposed or concerned: Get medical advice/ attention. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish.

Supplemental label elements

none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Rapidly absorbed through skin. 3.1 Substances Synonyms DMF Formula C3H7NO Molecular weight 73.09 g/mol CAS-No. 68-12-2 EC-No. 200-679-5 Index-No. 616-001-00-X Registration number 01-2119475605-32-XXXX

2.1 Classification of the substance or mixture

Labelling according Regulation (EC) No 1272/2008 Pictogram Signal word Danger Hazard statement(s) H226 Flammable liquid and vapour. H312 + H332 Harmful in contact with skin or if inhaled H319 Causes serious eye irritation. H360D May damage the unborn child. Sigma - D4551 Page 1 of 8 340 Precautionary statement(s) P201 Obtain special instructions before use. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face P308 + P313 IF exposed or concerned: Get medical advice/ attention. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. Supplemental Hazard none Statements 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Rapidly absorbed through skin. SECTION 3: Composition/information on ingredients 3.1 Substances Synonyms : DMF Formula : C3H7NO Molecular weight : 73.09 g/mol CAS-No. : 68-12-2 EC-No. : 200-679-5 Index-No. : 616-001-00-X Registration number : 01-2119475605-32-XXXX Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration N,N-Dimethylformamide Included in the Candidate List of Substances of Very High Concern (SVHC) according to Regulation (EC) No. 1907/2006 (REACH) CAS-No. 68-12-2 Flam. Liq. 3; Acute Tox. 4; Eye <= 100 % EC-No. 200-679-5 Irrit. 2; Repr. 1B; H226, H332, Index-No. 616-001-00-X H312, H319, H360 Registration number 01-2119475605-32-XXXX For the full text of the H-Statements mentioned in this Section, see Section 16. SECTION 4: First aid measures 4.1 Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Sigma - D4551 Page 2 of 8 341 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx) 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information Use water spray to cool unopened containers. SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). 6.4 Reference to other sections For disposal see section 13. SECTION 7: Handling and storage 7.1 Precautions for safe handling Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Handle and store under inert gas. Storage class (TRGS 510): Flammable liquids 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated Sigma - D4551 Page 3 of 8 342 SECTION 8: Exposure controls/personal protection 8.1 Control parameters Derived No Effect Level (DNEL) Application Area Exposure Health effect Value routes Workers Skin contact Acute systemic effects 26.3mg/kg BW/d Workers Inhalation Acute systemic effects 30 mg/m3 Workers Skin contact Long-term systemic effects 3.31mg/kg BW/d Workers Inhalation Long-term systemic effects 15 mg/m3 Workers Inhalation Long-term local effects 15 mg/m3 Workers Inhalation Acute local effects 30 mg/m3 Predicted No Effect Concentration (PNEC) Compartment Value Water 30 mg/l Soil 16.235 mg/kg Marine water 3 mg/kg Fresh water 30 mg/l Fresh water sediment 25.05 mg/kg Onsite sewage treatment plant 123 mg/l 8.2 Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nature latex/chloroprene Minimum layer thickness: 0.6 mm Break through time: 65 min Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Sigma - D4551 Page 4 of 8 343 Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties a) Appearance Form: liquid, clear Colour: colourless b) Odour amine-like c) Odour Threshold No data available d) pH 6.7 e) Melting point/freezing Melting point/range: -61 °C point f) Initial boiling point and 153 °C boiling range g) Flash point 58 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower Upper explosion limit: 15.2 %(V) flammability or Lower explosion limit: 2.2 %(V) explosive limits k) Vapour pressure 2.70 mmHg at 20 °C 3.87 mmHg at 25 °C l) Vapour density 2.52 - (Air = 1.0) m) Relative density 0.944 g/mL n) Water solubility completely miscible o) Partition coefficient: n- log Pow: -1.01 octanol/water p) Auto-ignition No data available temperature q) Decomposition No data available temperature r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information Relative vapour density 2.52 - (Air = 1.0) Sigma - D4551 Page 5 of 8 344 SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid Heat, flames and sparks. 10.5 Incompatible materials Strong oxidizing agents 10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5 SECTION 11: Toxicological information 11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - 2,800 mg/kg(N,N-Dimethylformamide) LC50 Inhalation - Rat - 4 h - 9 - 15 mg/l(N,N-Dimethylformamide) LD50 Dermal - Rabbit - 1,500 mg/kg(N,N-Dimethylformamide) Skin corrosion/irritation Skin - Human(N,N-Dimethylformamide) Result: Mild skin irritation - 24 h Serious eye damage/eye irritation Eyes - Rabbit(N,N-Dimethylformamide) Result: Moderate eye irritation Respiratory or skin sensitisation No data available(N,N-Dimethylformamide) Germ cell mutagenicity Mouse(N,N-Dimethylformamide) lymphocyte Mutation in mammalian somatic cells. Carcinogenicity This product is or contains a component that is not classifiable as to its classification.(N,N- Dimethylformamide) IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (N,N-Dimethylformamide) Reproductive toxicity May cause congenital malformation in the fetus.(N,N-Dimethylformamide) Specific target organ toxicity - single exposure No data available(N,N-Dimethylformamide) Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available(N,N-Dimethylformamide) Sigma - D4551 Page 6 of 8 345 Additional Information RTECS: LQ2100000 Warning: intolerance for alcohol can occur up to 4 days after dimethylform a potent liver toxin., Vomiting, Diarrhoea, Abdominal pain, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(N,N-Dimethylformamide) SECTION 12: Ecological information 12.1 Toxicity Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 9,000 - 13,000 mg/l - 96 h(N,N- Dimethylformamide) LC50 - Lepomis macrochirus (Bluegill) - 6,700 - 7,500 mg/l - 96 h(N,N- Dimethylformamide) LC50 - Pimephales promelas (fathead minnow) - 10,400 - 10,800 mg/l - 96 h(N,N-Dimethylformamide) LC50 - Oncorhynchus mykiss (rainbow trout) - 9,800 mg/l - 96 h(N,N- Dimethylformamide) LC50 - Lepomis macrochirus (Bluegill) - 6,300 mg/l - 96 h(N,N- Dimethylformamide) LC50 - Pimephales promelas (fathead minnow) - 10,600 mg/l - 96 h(N,N- Dimethylformamide) Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 9,600 - 13,100 mg/l - 48 h(N,N- other aquatic Dimethylformamide) invertebrates EC50 - Daphnia magna (Water flea) - 15,700 mg/l - 48 h(N,N- Dimethylformamide) Toxicity to algae LC50 - Desmodesmus subspicatus (green algae) - > 500 mg/l - 96 h(N,N- Dimethylformamide) 12.2 Persistence and degradability Biodegradability Result: > 90 % - Readily biodegradable 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available(N,N-Dimethylformamide) 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Other adverse effects No data available SECTION 13: Disposal considerations 13.1 Waste treatment methods Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. Sigma - D4551 Page 7 of 8 346 SECTION 14: Transport information 14.1 UN number ADR/RID: 2265 IMDG: 2265 IATA: 2265 14.2 UN proper shipping name ADR/RID: N,N-DIMETHYLFORMAMIDE IMDG: N,N-DIMETHYLFORMAMIDE IATA: N,N-Dimethylformamide 14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3 14.4 Packaging group ADR/RID: III IMDG: III IATA: III 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user No data available SECTION 15: Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Authorisations and/or restrictions on use 15.2 Chemical safety assessment A Chemical Safety Assessment has been carried out for this substance. SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. H226 Flammable liquid and vapour. H312 Harmful in contact with skin. H312 + H332 Harmful in contact with skin or if inhaled H319 Causes serious eye irritation. H332 Harmful if inhaled. H360 May damage fertility or the unborn child. H360D May damage the unborn child. Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma- aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale. Sigma - D4551 Page 8 of 8 347 2 3 Fire 1 0 Isopropyl alcohol MSDS Section 1: Chemical Product and Company Identification Product Name: Isopropyl alcohol Contact Information: Catalog Codes: SLI1153, SLI1579, SLI1906, SLI1246, Sciencelab.com, Inc. SLI1432 14025 Smith Rd. Houston, Texas 77396 CAS#: 67-63-0 US Sales: 1-800-901-7247 RTECS: NT8050000 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Isopropyl alcohol Order Online: ScienceLab.com CI#: Not available. Synonym: 2-Propanol Chemical Name: isopropanol Chemical Formula: C3-H8-O CHEMTREC (24HR Emergency Telephone), call: 1-800-424-9300 International CHEMTREC, call: 1-703-527-3887 For non-emergency assistance, call: 1-281-441-4400 Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Isopropyl alcohol 67-63-0 100 Toxicological Data on Ingredients: Isopropyl alcohol: ORAL (LD50): Acute: 5045 mg/kg [Rat]. 3600 mg/kg [Mouse]. 6410 mg/kg [Rabbit]. DERMAL (LD50): Acute: 12800 mg/kg [Rabbit]. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, sensitizer, permeator). Potential Chronic Health Effects: Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE]. The substance may be toxic to kidneys, liver, skin, central nervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage. Section 4: First Aid Measures p. 1 348 Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention. Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin Contact: Not available. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: Flammable. Auto-Ignition Temperature: 399°C (750.2°F) Flash Points: CLOSED CUP: 11.667°C (53°F) - 12.778 deg. C (55 deg. F) (TAG) Flammable Limits: LOWER: 2% UPPER: 12.7% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat. Flammable in presence of oxidizing materials. Non- flammable in presence of shocks. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Explosive in presence of open flames and sparks, of heat. Fire Fighting Media and Instructions: Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Special Remarks on Fire Hazards: Vapor may travel considerable distance to source of ignition and flash back. CAUTION: MAY BURN WITH NEAR INVISIBLE FLAME. Hydrogen peroxide sharply reduces the autoignition temperature of Isopropyl alcohol. After a delay, Isopropyl alcohol ignites on contact with dioxgenyl tetrafluorborate, chromium trioxide, and potassium tert-butoxide. When heated to decomposition it emits acrid smoke and fumes. Special Remarks on Explosion Hazards: Secondary alcohols are readily autooxidized in contact with oxygen or air, forming ketones and hydrogen peroxide. It can become potentially explosive. It reacts with oxygen to form dangerously unstable peroxides which can concentrate and explode during distillation or evaporation. The presence of 2-butanone increases the reaction rate for peroxide formation. Explosive in the form of vapor when exposed to heat or flame. May form explosive mixtures with air. Isopropyl alcohol + phosgene forms isopropyl chloroformate and hydrogen chloride. In the presence of iron salts, thermal decompositon can occur, whicn in some cases can become explosive. A homogeneous mixture of concentrated peroxides + isopropyl alcohol are capable of detonation by shock or heat. Barium perchlorate + isopropyl alcohol gives the highly explosive alkyl perchlorates. p. 2 349 It forms explosive mixtures with trinitormethane and hydrogen peroxide. It produces a violent explosive reaction when heated with aluminum isopropoxide + crotonaldehyde. Mixtures of isopropyl alcohol + nitroform are explosive. Section 6: Accidental Release Measures Small Spill: Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Large Spill: Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Section 7: Handling and Storage Precautions: Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, acids. Storage: Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Section 8: Exposure Controls/Personal Protection Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal Protection: Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: TWA: 983 STEL: 1230 (mg/m3) [Australia] TWA: 200 STEL: 400 (ppm) from ACGIH (TLV) [United States] [1999] TWA: 980 STEL: 1225 (mg/m3) from NIOSH TWA: 400 STEL: 500 (ppm) from NIOSH TWA: 400 STEL: 500 (ppm) [United Kingdom (UK)] TWA: 999 STEL: 1259 (mg/m3) [United Kingdom (UK)] TWA: 400 STEL: 500 (ppm) from OSHA (PEL) [United States] TWA: 980 STEL: 1225 (mg/m3) from OSHA (PEL) [United States]Consult local authorities for acceptable exposure limits. Section 9: Physical and Chemical Properties Physical state and appearance: Liquid. Odor: Pleasant. Odor resembling that of a mixture of ethanol and acetone. Taste: Bitter. (Slight.) Molecular Weight: 60.1 g/mole p. 3 350 Color: Colorless. pH (1% soln/water): Not available. Boiling Point: 82.5°C (180.5°F) Melting Point: -88.5°C (-127.3°F) Critical Temperature: 235°C (455°F) Specific Gravity: 0.78505 (Water = 1) Vapor Pressure: 4.4 kPa (@ 20°C) Vapor Density: 2.07 (Air = 1) Volatility: Not available. Odor Threshold: 22 ppm (Sittig, 1991) 700 ppm for unadapted panelists (Verschuren, 1983). Water/Oil Dist. Coeff.: The product is equally soluble in oil and water; log(oil/water) = 0.1 Ionicity (in Water): Not available. Dispersion Properties: See solubility in water, methanol, diethyl ether, n-octanol, acetone. Solubility: Easily soluble in cold water, hot water, methanol, diethyl ether, n-octanol, acetone. Insoluble in salt solution. Soluble in benzene. Miscible with most organic solvents including alcohol, ethyl alcohol, chloroform. Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Heat, Ignition sources, incompatible materials Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis. Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Reacts violently with hydrogen + palladium combination, nitroform, oleum, COCl2, aluminum triisopropoxide, oxidants Incompatible with acetaldehyde, chlorine, ethylene oxide, isocyanates, acids, alkaline earth, alkali metals, caustics, amines, crotonaldehyde, phosgene, ammonia. Isopropyl alcohol reacts with metallic aluminum at high temperatures. Isopropyl alcohol attacks some plastics, rubber, and coatings. Vigorous reaction with sodium dichromate + sulfuric acid. Special Remarks on Corrosivity: May attack some forms of plastic, rubber and coating Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 3600 mg/kg [Mouse]. Acute dermal toxicity (LD50): 12800 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 16000 8 hours [Rat]. Chronic Effects on Humans: CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE]. May cause damage to the following organs: kidneys, liver, skin, central nervous system (CNS). p. 4 351 Other Toxic Effects on Humans: Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, sensitizer, permeator). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: M a y c a u s e a d v e r s e r e p r o d u c t i v e / t e r a t o g e n i c e f f e c t s ( f e r t i l i t y , f e t o x i c i t y , d e v e l o p m e n t a l abnormalities(developmental toxin)) based on animal studies. Detected in maternal milk in human. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: May cause mild skin irritation, and sensitization. Eyes: Can cause eye irritation. Inhalation: Breathing in small amounts of this material during normal handling is not likely to cause harmful effects. However, breathing large amounts may be harmful and may affect the respiratory system and mucous membranes (irritation), behavior and brain (Central nervous system depression - headache, dizziness, drowsiness, stupor, incoordination, unconciousness, coma and possible death), peripheral nerve and senstation, blood, urinary system, and liver. Ingestion: Swallowing small amouts during normal handling is not likely to cause harmful effects. Swallowing large amounts may be harmful. Swallowing large amounts may cause gastrointestinal tract irritation with nausea, vomiting and diarrhea, abdominal pain. It also may affect the urinary system, cardiovascular system, sense organs, behavior or central nervous system (somnolence, generally depressed activity, irritability, headache, dizziness, drowsiness), liver, and respiratory system (breathing difficulty). Chronic Potential Health Effects: May cause defatting of the skin and dermatitis and allergic reaction. May cause adverse reproductive effects based on animal data (studies). Section 12: Ecological Information Ecotoxicity: Ecotoxicity in water (LC50): 100000 mg/l 96 hours [Fathead Minnow]. 64000 mg/l 96 hours [Fathead Minnow]. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information DOT Classification: CLASS 3: Flammable liquid. Identification: : Isopropyl Alcohol UNNA: 1219 PG: II Special Provisions for Transport: Not available. Section 15: Other Regulatory Information Federal and State Regulations: Connecticut hazardous material survey.: Isopropyl alcohol Illinois toxic substances disclosure to employee act: Isopropyl alcohol Rhode Island RTK hazardous substances: Isopropyl alcohol Pennsylvania RTK: Isopropyl alcohol Florida: Isopropyl alcohol Minnesota: Isopropyl alcohol Massachusetts RTK: Isopropyl alcohol New Jersey: Isopropyl alcohol New Jersey spill list: Isopropyl alcohol Director's list of Hazardous Substances: Isopropyl alcohol Tennesee: Isopropyl alcohol TSCA 8(b) inventory: Isopropyl alcohol TSCA 4(a) final testing order: Isopropyl alcohol TSCA 8(a) IUR: Isopropyl alcohol TSCA 8(d) H p. 5 352 and S data reporting: Isopropyl alcohol: Effective date: 12/15/86 Sunset Date: 12/15/96 TSCA 12(b) one time export: Isopropyl alcohol SARA 313 toxic chemical notification and release reporting: Isopropyl alcohol Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects (TOXIC). DSCL (EEC): R11- Highly flammable. R36- Irritating to eyes. S7- Keep container tightly closed. S16- Keep away from sources of ignition - No smoking. S24/25- Avoid contact with skin and eyes. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 3 Reactivity: 0 Personal Protection: h National Fire Protection Association (U.S.A.): Health: 1 Flammability: 3 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles. Section 16: Other Information References: Not available. Other Special Considerations: Not available. Created: 10/09/2005 05:53 PM Last Updated: 05/21/2013 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. p. 6 353 3 2 Fire 3 1 0 Acetic anhydride MSDS Section 1: Chemical Product and Company Identification Product Name: Acetic anhydride Contact Information: Catalog Codes: SLA1693 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 108-24-7 Houston, Texas 77396 RTECS: AK1925000 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Acetic anhydride Order Online: ScienceLab.com CI#: Not available. Synonym: Chemical Formula: (CH3CO)2) CHEMTREC (24HR Emergency Telephone), call: 1-800-424-9300 International CHEMTREC, call: 1-703-527-3887 For non-emergency assistance, call: 1-281-441-4400 Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Acetic anhydride 108-24-7 100 Toxicological Data on Ingredients: Acetic anhydride: ORAL (LD50): Acute: 1780 mg/kg [Rat]. DERMAL (LD50): Acute: 4000 mg/kg [Rabbit]. Section 3: Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Very hazardous in case of skin contact (corrosive). Hazardous in case of skin contact (permeator). Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection. p. 1 354 Section 4: First Aid Measures Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention immediately. Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: Flammable. Auto-Ignition Temperature: 316°C (600.8°F) Flash Points: CLOSED CUP: 49°C (120.2°F). OPEN CUP: 51°C (123.8°F). Flammable Limits: LOWER: 2.7% UPPER: 10.3% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Flammable in presence of heat. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: Flammable liquid. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion. Special Remarks on Fire Hazards: Not available. Special Remarks on Explosion Hazards: Not available. Section 6: Accidental Release Measures Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal. p. 2 355 Large Spill: Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use water spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Section 7: Handling and Storage Precautions: Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Storage: Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Section 8: Exposure Controls/Personal Protection Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal Protection: Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: TWA: 5 TWA: 20 Consult local authorities for acceptable exposure limits. Section 9: Physical and Chemical Properties Physical state and appearance: Liquid. Odor: Strong. Taste: Strong. Molecular Weight: 102.09 g/mole Color: Light. pH (1% soln/water): Not available. Boiling Point: 139.9°C (283.8°F) Melting Point: -73.1 (-99.6°F) Critical Temperature: Not available. Specific Gravity: 1.08 (Water = 1) Vapor Pressure: 0.5 kPa (@ 20°C) Vapor Density: 3.52 (Air = 1) p. 3 356 Volatility: Not available. Odor Threshold: 0.1 ppm Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: Not available. Solubility: Not available. Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Not available. Incompatibility with various substances: Not available. Corrosivity: Not available. Special Remarks on Reactivity: Not available. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 1780 mg/kg [Rat]. Acute dermal toxicity (LD50): 4000 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 1000 4 hours [Rat]. Chronic Effects on Humans: Causes damage to the following organs: lungs, mucous membranes. Other Toxic Effects on Humans: Extremely hazardous in case of skin contact (irritant), of ingestion, . Very hazardous in case of skin contact (corrosive). Hazardous in case of skin contact (permeator), of eye contact (corrosive), of inhalation (lung corrosive). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. Special Remarks on other Toxic Effects on Humans: Not available. Section 12: Ecological Information Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself. Special Remarks on the Products of Biodegradation: Not available. p. 4 357 Section 13: Disposal Considerations Waste Disposal: Section 14: Transport Information DOT Classification: Class 8: Corrosive material Identification: : Acetic Anhydride UNNA: UN1715 PG: II Special Provisions for Transport: Not available. Section 15: Other Regulatory Information Federal and State Regulations: Pennsylvania RTK: Acetic anhydride Massachusetts RTK: Acetic anhydride TSCA 8(b) inventory: Acetic anhydride CERCLA: Hazardous substances.: Acetic anhydride Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). Other Classifications: WHMIS (Canada): CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS E: Corrosive liquid. DSCL (EEC): R10- Flammable. R20/22- Harmful by inhalation and if swallowed. R34- Causes burns. HMIS (U.S.A.): Health Hazard: 3 Fire Hazard: 2 Reactivity: 0 Personal Protection: National Fire Protection Association (U.S.A.): Health: 3 Flammability: 2 Reactivity: 1 Specific hazard: Protective Equipment: Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Face shield. Section 16: Other Information References: Not available. Other Special Considerations: Not available. Created: 10/10/2005 08:13 PM Last Updated: 05/21/2013 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume p. 5 358 no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. p. 6 359 3 2 Fire 3 0 Acetic acid MSDS Section 1: Chemical Product and Company Identification Product Name: Acetic acid Contact Information: Catalog Codes: SLA3784, SLA1438, SLA2101, SLA3604, Sciencelab.com, Inc. SLA1258 14025 Smith Rd. Houston, Texas 77396 CAS#: 64-19-7 US Sales: 1-800-901-7247 RTECS: AF1225000 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Acetic acid Order Online: ScienceLab.com CI#: Not applicable. Synonym: Acetic acid; glacial acetic acid Chemical Name: Acetic Acid, Glacial Chemical Formula: C2-H4-O2 CHEMTREC (24HR Emergency Telephone), call: 1-800-424-9300 International CHEMTREC, call: 1-703-527-3887 For non-emergency assistance, call: 1-281-441-4400 Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Acetic acid 64-19-7 100 Toxicological Data on Ingredients: Acetic acid: ORAL (LD50): Acute: 3310 mg/kg [Rat]. 4960 mg/kg [Mouse]. 3530 mg/kg [Rat]. DERMAL (LD50): Acute: 1060 mg/kg [Rabbit]. VAPOR (LC50): Acute: 5620 ppm 1 hours [Mouse]. Section 3: Hazards Identification Potential Acute Health Effects: Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous in case of skin contact (corrosive, permeator), of eye contact (corrosive). Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Potential Chronic Health Effects: Hazardous in case of skin contact (irritant), of ingestion, of inhalation. CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to kidneys, mucous membranes, skin, teeth. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated p. 1 360 or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection. Section 4: First Aid Measures Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention immediately. Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: Flammable. Auto-Ignition Temperature: 463°C (865.4°F) Flash Points: CLOSED CUP: 39°C (102.2°F). OPEN CUP: 43°C (109.4°F). Flammable Limits: LOWER: 4% UPPER: 19.9% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizing materials, of metals. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Slightly explosive in presence of oxidizing materials. Fire Fighting Media and Instructions: Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion. Special Remarks on Fire Hazards: Reacts with metals to produces flammable hydrogen gas. It will ignite on contact with potassium-tert-butoxide. A mixture of ammonium nitrate and acetic acid ignites when warmed, especially if warmed. Special Remarks on Explosion Hazards: p. 2 361 Acetic acid vapors may form explosive mixtures with air. Reactions between acetic acid and the following materials are potentially explosive: 5-azidotetrazole, bromine pentafluoride, chromium trioxide, hydrogen peroxide, potassium permanganate, sodium peroxide, and phorphorus trichloride. Dilute acetic acid and dilute hydrogen can undergo an exothermic reaction if heated, forming peracetic acid which is explosive at 110 degrees C. Reaction between chlorine trifluoride and acetic acid is very violent, sometimes explosive. Section 6: Accidental Release Measures Small Spill: Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. If necessary: Neutralize the residue with a dilute solution of sodium carbonate. Large Spill: Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. If the product is in its solid form: Use a shovel to put the material into a convenient waste disposal container. If the product is in its liquid form: Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Absorb with an inert material and put the spilled material in an appropriate waste disposal. Do not touch spilled material. Use water spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Neutralize the residue with a dilute solution of sodium carbonate. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Section 7: Handling and Storage Precautions: \Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducing agents, metals, acids, alkalis. Storage: Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Section 8: Exposure Controls/Personal Protection Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal Protection: Splash goggles. Synthetic apron. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves (impervious). Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: TWA: 10 STEL: 15 (ppm) [Australia] TWA: 25 STEL: 27 (mg/m3) [Australia] TWA: 10 STEL: 15 (ppm) from NIOSH TWA: 25 STEL: 37 (mg/m3) from NIOSH TWA: 10 STEL: 15 (ppm) [Canada] TWA: 26 STEL: 39 (mg/m3) [Canada] TWA: 25 STEL: 37 (mg/m3) TWA: 10 STEL: 15 (ppm) from ACGIH (TLV) [United States] [1999] TWA: 10 (ppm) from OSHA (PEL) [United States] TWA: 25 (mg/m3) from OSHA (PEL) [United States]Consult local authorities for acceptable exposure limits. Section 9: Physical and Chemical Properties p. 3 362 Physical state and appearance: Liquid. Odor: Pungent, vinegar-like, sour (Strong.) Taste: Vinegar, sour (Strong.) Molecular Weight: 60.05 g/mole Color: Colorless. Clear (Light.) pH (1% soln/water): 2 [Acidic.] Boiling Point: 118.1°C (244.6°F) Melting Point: 16.6°C (61.9°F) Critical Temperature: 321.67°C (611°F) Specific Gravity: 1.049 (Water = 1) Vapor Pressure: 1.5 kPa (@ 20°C) Vapor Density: 2.07 (Air = 1) Volatility: Not available. Odor Threshold: 0.48 ppm Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.2 Ionicity (in Water): Not available. Dispersion Properties: See solubility in water, diethyl ether, acetone. Solubility: Easily soluble in cold water, hot water. Soluble in diethyl ether, acetone. Miscible with Glycerol, alcohol, Benzene, Carbon Tetrachloride. Practically insoluble in Carbon Disulfide. Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Heat, ignition sources, incompatible materials Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, metals, acids, alkalis. Corrosivity: Highly corrosive in presence of stainless steel(304). Slightly corrosive in presence of aluminum, of copper. Non-corrosive in presence of stainless steel(316). Special Remarks on Reactivity: Reacts violently with strong oxidizing agents, acetaldehyde, and acetic anhydride. Material can react with metals, strong bases, amines, carbonates, hydroxides, phosphates, many oxides,cyanides, sulfides, chromic acid, nitric acid, hydrogen peroxide, carbonates. ammonium nitrate, ammonium thiosulfate, chlorine trifluoride, chlorosulfonic acid, perchloric acid, permanganates, xylene, oleum, potassium hydroxide, sodium hydroxide, phosphorus isocyanate, ethylenediamine, ethylene imine. Special Remarks on Corrosivity: Moderate corrosive effect on bronze. No corrosion data on brass Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion. p. 4 363 Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 3310 mg/kg [Rat]. Acute dermal toxicity (LD50): 1060 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 5620 1 hours [Mouse]. Chronic Effects on Humans: MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May cause damage to the following organs: kidneys, mucous membranes, skin, teeth. Other Toxic Effects on Humans: Extremely hazardous in case of inhalation (lung corrosive). Very hazardous in case of skin contact (irritant), of ingestion, . Hazardous in case of skin contact (corrosive, permeator), of eye contact (corrosive). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: May affect genetic material and may cause reproductive effects based on animal data. No human data found. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Extremely irritating and corrosive. Causes skin irritation (reddening and itching, inflammation). May cause blistering , tissue damage and burns. Eyes: Extremely irritating and corrosive. Causes eye irritation, lacrimation, redness, and pain. May cause burns, blurred vision, conjunctivitis, conjunctival and corneal destruction and permanent injury. Inhalation: Causes severe respiratory tract irritation. Affects the sense organs (nose, ear, eye, taste), and blood. May cause chemical pneumonitis, bronchitis, and pulmonary edema. Severe exposure may result in lung tissue damage and corrosion (ulceration) of the mucous membranes. Inhalation may also cause rhinitis, sneezing, coughing, oppressive feeling in the chest or chest pain, dyspnea, wheezing, tachypnea, cyanosis, salivation, nausea, giddiness, muscular weakness. Ingestion: Moderately toxic. Corrosive. Causes gastrointestinal tract irritation (burning and pain of the mouth, throat, and abdomen, coughing, ulceration, bleeding, nausea, abdomial spasms, vomiting, hematemesis, diarrhea. May Also affect the liver (impaired liver function), behavior (convulsions, giddines, muscular weakness), and the urinary system - kidneys (Hematuria, Albuminuria, Nephrosis, acute renal failure, acute tubular necrosis). May also cause dyspnea or asphyxia. May also lead to shock, coma and death. Chronic Potential Health Effects: Chronic exposure via ingestion may cause blackening or erosion of the teeth and jaw necrosis, pharyngitis, and gastritis. It may also behavior (similar to acute ingestion), and metabolism (weight loss). Chronic exposure via inhalation may cause asthma and/or bronchitis with cough, phlegm, and/or shortness of breath . It may also affect the blood (decreased leukocyte count), and urinary system (kidneys). Repeated or prolonged skin contact may cause thickening, blackening, and cracking of the skin. Section 12: Ecological Information Ecotoxicity: Ecotoxicity in water (LC50): 423 mg/l 24 hours [Fish (Goldfish)]. 88 ppm 96 hours [Fish (fathead minnow)]. 75 ppm 96 hours [Fish (bluegill sunfish)]. >100 ppm 96 hours [Daphnia]. BOD5 and COD: BOD-5: 0.34-0.88 g oxygen/g Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information DOT Classification: p. 5 364 CLASS 3: Flammable liquid. Class 8: Corrosive material Identification: : Acetic Acid, Glacial UNNA: 2789 PG: II Special Provisions for Transport: Not available. Section 15: Other Regulatory Information Federal and State Regulations: New York release reporting list: Acetic acid Rhode Island RTK hazardous substances: Acetic acid Pennsylvania RTK: Acetic acid Florida: Acetic acid Minnesota: Acetic acid Massachusetts RTK: Acetic acid New Jersey: Acetic acid California Director's List of Hazardous Subtances (8 CCR 339): Acetic acid TSCA 8(b) inventory: Acetic acid CERCLA: Hazardous substances.: Acetic acid: 5000 lbs. (2268 kg) Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS E: Corrosive liquid. DSCL (EEC): R10- Flammable. R35- Causes severe burns. S23- Do not breathe gas/fumes/vapour/spray [***] S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). HMIS (U.S.A.): Health Hazard: 3 Fire Hazard: 2 Reactivity: 0 Personal Protection: H National Fire Protection Association (U.S.A.): Health: 3 Flammability: 2 Reactivity: 0 Specific hazard: Protective Equipment: Gloves (impervious). Synthetic apron. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles. Section 16: Other Information References: Not available. Other Special Considerations: Not available. Created: 10/09/2005 03:35 PM Last Updated: 05/21/2013 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume p. 6 365 no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. p. 7 366 2 3 Fire 1 0 Acetone MSDS Section 1: Chemical Product and Company Identification Product Name: Acetone Contact Information: Catalog Codes: SLA3502, SLA1645, SLA3151, SLA3808 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 67-64-1 Houston, Texas 77396 RTECS: AL3150000 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Acetone Order Online: ScienceLab.com CI#: Not applicable. Synonym: 2-propanone; Dimethyl Ketone; Dimethylformaldehyde; Pyroacetic Acid Chemical Name: Acetone Chemical Formula: C3-H6-O CHEMTREC (24HR Emergency Telephone), call: 1-800-424-9300 International CHEMTREC, call: 1-703-527-3887 For non-emergency assistance, call: 1-281-441-4400 Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Acetone 67-64-1 100 Toxicological Data on Ingredients: Acetone: ORAL (LD50): Acute: 5800 mg/kg [Rat]. 3000 mg/kg [Mouse]. 5340 mg/kg [Rabbit]. VAPOR (LC50): Acute: 50100 mg/m 8 hours [Rat]. 44000 mg/m 4 hours [Mouse]. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator). Potential Chronic Health Effects: CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [SUSPECTED]. The substance is toxic to central nervous system (CNS). The substance may be toxic to kidneys, the reproductive system, liver, skin. Repeated or prolonged exposure to the substance can produce target organs damage. Section 4: First Aid Measures p. 1 367 Eye Contact: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention. Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: Flammable. Auto-Ignition Temperature: 465°C (869°F) Flash Points: CLOSED CUP: -20°C (-4°F). OPEN CUP: -9°C (15.8°F) (Cleveland). Flammable Limits: LOWER: 2.6% UPPER: 12.8% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of open flames and sparks, of oxidizing materials, of acids. Fire Fighting Media and Instructions: Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Special Remarks on Fire Hazards: Vapor may travel considerable distance to source of ignition and flash back. Special Remarks on Explosion Hazards: Forms explosive mixtures with hydrogen peroxide, acetic acid, nitric acid, nitric acid + sulfuric acid, chromic anydride, chromyl chloride, nitrosyl chloride, hexachloromelamine, nitrosyl perchlorate, nitryl perchlorate, permonosulfuric acid, thiodiglycol + hydrogen peroxide, potassium ter-butoxide, sulfur dichloride, 1-methyl-1,3-butadiene, bromoform, carbon, air, chloroform, thitriazylperchlorate. Section 6: Accidental Release Measures Small Spill: Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. p. 2 368 Large Spill: Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Section 7: Handling and Storage Precautions: Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducing agents, acids, alkalis. Storage: Store in a segregated and approved area (flammables area) . Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Keep away from direct sunlight and heat and avoid all possible sources of ignition (spark or flame). Section 8: Exposure Controls/Personal Protection Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal Protection: Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: TWA: 500 STEL: 750 (ppm) from ACGIH (TLV) [United States] TWA: 750 STEL: 1000 (ppm) from OSHA (PEL) [United States] TWA: 500 STEL: 1000 [Austalia] TWA: 1185 STEL: 2375 (mg/m3) [Australia] TWA: 750 STEL: 1500 (ppm) [United Kingdom (UK)] TWA: 1810 STEL: 3620 (mg/m3) [United Kingdom (UK)] TWA: 1800 STEL: 2400 from OSHA (PEL) [United States]Consult local authorities for acceptable exposure limits. Section 9: Physical and Chemical Properties Physical state and appearance: Liquid. Odor: Fruity. Mint-like. Fragrant. Ethereal Taste: Pungent, Sweetish Molecular Weight: 58.08 g/mole Color: Colorless. Clear pH (1% soln/water): Not available. Boiling Point: 56.2°C (133.2°F) Melting Point: -95.35 (-139.6°F) Critical Temperature: 235°C (455°F) Specific Gravity: 0.79 (Water = 1) p. 3 369 Vapor Pressure: 24 kPa (@ 20°C) Vapor Density: 2 (Air = 1) Volatility: Not available. Odor Threshold: 62 ppm Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.2 Ionicity (in Water): Not available. Dispersion Properties: See solubility in water. Solubility: Easily soluble in cold water, hot water. Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Excess heat, ignition sources, exposure to moisture, air, or water, incompatible materials. Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, acids, alkalis. Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Not available. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 3000 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 44000 mg/m3 4 hours [Mouse]. Chronic Effects on Humans: CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [SUSPECTED]. Causes damage to the following organs: central nervous system (CNS). May cause damage to the following organs: kidneys, the reproductive system, liver, skin. Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: May affect genetic material (mutagenicity) based on studies with yeast (S. cerevisiae), bacteria, and hamster fibroblast cells. May cause reproductive effects (fertility) based upon animal studies. May contain trace amounts of benzene and formaldehyde which may cancer and birth defects. Human: passes the placental barrier. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: May cause skin irritation. May be harmful if absorbed through the skin. Eyes: Causes eye irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Inhalation: Inhalation at high concentrations affects the sense organs, brain and causes respiratory tract irritation. It also may affect the Central Nervous System (behavior) characterized by dizzness, drowsiness, confusion, headache, muscle weakeness, and possibly motor incoordination, speech abnormalities, narcotic effects and coma. Inhalation may also affect the gastrointestinal tract (nausea, vomiting). Ingestion: May cause irritation of the digestive (gastrointestinal) tract (nausea, vomiting). It may also p. 4 370 affect the Central Nevous System (behavior), characterized by depression, fatigue, excitement, stupor, coma, headache, altered sleep time, ataxia, tremors as well at the blood, liver, and urinary system (kidney, bladder, ureter) and endocrine system. May also have musculoskeletal effects. Chronic Potential Health Effects: Skin: May cause dermatitis. Eyes: Eye irritation. Section 12: Ecological Information Ecotoxicity: Ecotoxicity in water (LC50): 5540 mg/l 96 hours [Trout]. 8300 mg/l 96 hours [Bluegill]. 7500 mg/l 96 hours [Fatthead Minnow]. 0.1 ppm any hours [Water flea]. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information DOT Classification: CLASS 3: Flammable liquid. Identification: : Acetone UNNA: 1090 PG: II Special Provisions for Transport: Not available. Section 15: Other Regulatory Information Federal and State Regulations: California prop. 65: This product contains the following ingredients for which the State of California has found to cause reproductive harm (male) which would require a warning under the statute: Benzene California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: Benzene California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: Benzene, Formaldehyde Connecticut hazardous material survey.: Acetone Illinois toxic substances disclosure to employee act: Acetone Illinois chemical safety act: Acetone New York release reporting list: Acetone Rhode Island RTK hazardous substances: Acetone Pennsylvania RTK: Acetone Florida: Acetone Minnesota: Acetone Massachusetts RTK: Acetone Massachusetts spill list: Acetone New Jersey: Acetone New Jersey spill list: Acetone Louisiana spill reporting: Acetone California List of Hazardous Substances (8 CCR 339): Acetone TSCA 8(b) inventory: Acetone TSCA 4(a) final test rules: Acetone TSCA 8(a) IUR: Acetone Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects (TOXIC). p. 5 371 DSCL (EEC): R11- Highly flammable. R36- Irritating to eyes. S9- Keep container in a well-ventilated place. S16- Keep away from sources of ignition - No smoking. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 3 Reactivity: 0 Personal Protection: h National Fire Protection Association (U.S.A.): Health: 1 Flammability: 3 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles. Section 16: Other Information References: -Material safety data sheet issued by: la Commission de la Santé et de la Sécurité du Travail du Québec. -The Sigma- Aldrich Library of Chemical Safety Data, Edition II. -Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New York N.Y., Van Nostrand Reinold, 1987. LOLI, RTECS, HSDB databases. Other MSDSs Other Special Considerations: Not available. Created: 10/10/2005 08:13 PM Last Updated: 05/21/2013 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. p. 6 372 Creation Date 26-Oct-2009 Revision Date 19-Jan-2018 Revision Number 3 1. Identification Product Name n-Hexane Cat No. : AC326920000; AC326920010; AC326920025; AC326921000; AC326922500 CAS-No 110-54-3 Synonyms Hex Recommended Use Laboratory chemicals. Uses advised against Not for food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Company Fisher Scientific Acros Organics One Reagent Lane Fair Lawn, NJ 07410 Tel: (201) 796-7100 Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99 CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887 2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) Flammable liquids Category 2 Skin Corrosion/irritation Category 2 Serious Eye Damage/Eye Irritation Category 2 Reproductive Toxicity Category 2 Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system, Central nervous system (CNS). Specific target organ toxicity - (repeated exposure) Category 1 Target Organs - Liver, Heart, Blood. Aspiration Toxicity Category 1 Label Elements Signal Word Danger Hazard Statements Highly flammable liquid and vapor May be fatal if swallowed and enters airways Causes skin irritation ______________________________________________________________________________________________ Page 1 / 8 373 n-Hexane Revision Date 19-Jan-2018 Causes serious eye irritation May cause respiratory irritation May cause drowsiness or dizziness Suspected of damaging fertility Causes damage to organs through prolonged or repeated exposure Precautionary Statements Prevention Obtain special instructions before use Do not handle until all safety precautions have been read and understood Use personal protective equipment as required Wash face, hands and any exposed skin thoroughly after handling Wear eye/face protection Do not breathe dust/fume/gas/mist/vapors/spray Do not eat, drink or smoke when using this product Use only outdoors or in a well-ventilated area Keep away from heat/sparks/open flames/hot surfaces. - No smoking Keep container tightly closed Ground/bond container and receiving equipment Use explosion-proof electrical/ventilating/lighting/equipment Use only non-sparking tools Take precautionary measures against static discharge Keep cool Response IF exposed or concerned: Get medical attention/advice Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing Skin If skin irritation occurs: Get medical advice/attention IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower Wash contaminated clothing before reuse Eyes IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing If eye irritation persists: Get medical advice/attention Ingestion IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician Do NOT induce vomiting Fire In case of fire: Use CO2, dry chemical, or foam for extinction Storage Store locked up Store in a well-ventilated place. Keep container tightly closed Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) Toxic to aquatic life with long lasting effects 3. Composition/Information on Ingredients ______________________________________________________________________________________________ Page 2 / 8 374 n-Hexane Revision Date 19-Jan-2018 Component CAS-No Weight % Hexane 110-54-3 >95 4. First-aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention. Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Obtain medical attention. Aspiration into lungs can produce severe lung damage. Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately. If vomiting occurs, lean victim forward to reduce the risk of aspiration. Most important symptoms and Breathing difficulties. Inhalation of high vapor concentrations may cause symptoms like effects headache, dizziness, tiredness, nausea and vomiting Notes to Physician Treat symptomatically 5. Fire-fighting measures Suitable Extinguishing Media CO 2, dry chemical, dry sand, alcohol-resistant foam. Cool closed containers exposed to fire with water spray. Unsuitable Extinguishing Media Water may be ineffective, This material is lighter than water and insoluble in water. The fire could easily be spread by the use of water in an area where the water cannot be contained Flash Point -22 °C / -7.6 °F Method - No information available Autoignition Temperature 223 °C / 433.4 °F Explosion Limits Upper 7.5 vol % Lower 1.1 vol % Sensitivity to Mechanical Impact No information available Sensitivity to Static Discharge No information available Specific Hazards Arising from the Chemical Flammable. Risk of ignition. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Containers may explode when heated. Hazardous Combustion Products Carbon monoxide (CO) Carbon dioxide (CO2) Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors. NFPA Health Flammability Instability Physical hazards 2 3 0 N/A 6. Accidental release measures Personal Precautions Use personal protective equipment. Ensure adequate ventilation. Evacuate personnel to safe areas. Remove all sources of ignition. Take precautionary measures against static discharges. ______________________________________________________________________________________________ Page 3 / 8 375 n-Hexane Revision Date 19-Jan-2018 Environmental Precautions Do not flush into surface water or sanitary sewer system. Avoid release to the environment. Collect spillage. Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable, closed containers for disposal. Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Take precautionary measures against static discharges. 7. Handling and storage Handling Wear personal protective equipment. Do not get in eyes, on skin, or on clothing. Do not breathe vapors or spray mist. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. Use explosion-proof equipment. Take precautionary measures against static discharges. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded. Storage Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat and sources of ignition. Flammables area. 8. Exposure controls / personal protection Exposure Guidelines Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA) Hexane TWA: 50 ppm (Vacated) TWA: 50 ppm IDLH: 1100 ppm TWA: 50 ppm Skin (Vacated) TWA: 180 mg/m3 TWA: 50 ppm TWA: 176 mg/m3 TWA: 500 ppm TWA: 180 mg/m3 TWA: 1800 mg/m3 Legend ACGIH - American Conference of Governmental Industrial Hygienists OSHA - Occupational Safety and Health Administration NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Use explosion-proof electrical/ventilating/lighting/equipment. Personal Protective Equipment Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure. Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Hygiene Measures Handle in accordance with good industrial hygiene and safety practice. 9. Physical and chemical properties Physical State Liquid Appearance Colorless Odor Petroleum distillates Odor Threshold No information available pH Not applicable Melting Point/Range -95 °C / -139 °F Boiling Point/Range 69 °C / 156.2 °F @ 760 mmHg ______________________________________________________________________________________________ Page 4 / 8 376 n-Hexane Revision Date 19-Jan-2018 Flash Point -22 °C / -7.6 °F Evaporation Rate No information available Flammability (solid,gas) Not applicable Flammability or explosive limits Upper 7.5 vol % Lower 1.1 vol % Vapor Pressure 160 mbar @ 20 °C Vapor Density 2.97 Specific Gravity 0.659 Solubility immiscible Partition coefficient; n-octanol/water No data available Autoignition Temperature 223 °C / 433.4 °F Decomposition Temperature No information available Viscosity 0.31 mPa s at 20 °C Molecular Formula C6 H14 Molecular Weight 86.18 10. Stability and reactivity Reactive Hazard None known, based on information available Stability Stable under normal conditions. Conditions to Avoid Incompatible products. Heat, flames and sparks. Exposure to light. Keep away from open flames, hot surfaces and sources of ignition. Incompatible Materials Strong oxidizing agents, Halogens Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2) Hazardous Polymerization Hazardous polymerization does not occur. Hazardous Reactions None under normal processing. 11. Toxicological information Acute Toxicity Product Information Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Hexane LD50 = 25 g/kg ( Rat ) LD50 = 3000 mg/kg ( Rabbit ) LC50 = 48000 ppm ( Rat ) 4 h Toxicologically Synergistic No information available Products Delayed and immediate effects as well as chronic effects from short and long-term exposure Irritation Irritating to eyes and skin Sensitization No information available Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen. Component CAS-No IARC NTP ACGIH OSHA Mexico Hexane 110-54-3 Not listed Mutagenic Effects Mutagenic effects have occurred in experimental animals. Reproductive Effects Experiments have shown reproductive toxicity effects on laboratory animals. Developmental Effects Developmental effects have occurred in experimental animals. ______________________________________________________________________________________________ Page 5 / 8 377 n-Hexane Revision Date 19-Jan-2018 Teratogenicity Teratogenic effects have occurred in experimental animals. STOT - single exposure Respiratory system Central nervous system (CNS) STOT - repeated exposure Liver Heart Blood Aspiration hazard No information available Symptoms / effects,both acute and Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, delayed tiredness, nausea and vomiting Endocrine Disruptor Information No information available Other Adverse Effects Tumorigenic effects have been reported in experimental animals. See actual entry in RTECS for complete information. 12. Ecological information Ecotoxicity Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. The product contains following substances which are hazardous for the environment. Component Freshwater Algae Freshwater Fish Microtox Water Flea Hexane Not listed LC50: 2.1 - 2.98 mg/L, 96h Not listed EC50: 3.87 mg/L/48h flow-through (Pimephales promelas) Persistence and Degradability Persistence is unlikely based on information available. Bioaccumulation/ Accumulation No information available. Mobility Will likely be mobile in the environment due to its volatility. Component log Pow Hexane 4.11 13. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification. 14. Transport information DOT UN-No UN1208 Proper Shipping Name Hexanes Hazard Class 3 Packing Group II TDG UN-No UN1208 Proper Shipping Name HEXANES Hazard Class 3 Packing Group II IATA UN-No UN1208 Proper Shipping Name Hexanes Hazard Class 3 Packing Group II IMDG/IMO UN-No UN1208 Proper Shipping Name Hexanes Hazard Class 3 ______________________________________________________________________________________________ Page 6 / 8 378 n-Hexane Revision Date 19-Jan-2018 Packing Group II 15. Regulatory information All of the components in the product are on the following Inventory lists: Australia Complete Regulatory Information contained in following SDS's X = listed China Canada The product is classified and labeled according to EC directives or corresponding national laws The product is classified and labeled in accordance with Directive 1999/45/EC Europe TSCA Korea Philippines Japan U.S.A. (TSCA) Canada (DSL/NDSL) Europe (EINECS/ELINCS/NLP) Australia (AICS) Korea (ECL) China (IECSC) Japan (ENCS) Philippines (PICCS) International Inventories Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL Hexane X - 203-777-6 438-390 X -3 Legend: X - Listed E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA. F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA. N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. P - Indicates a commenced PMN substance R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA. S - Indicates a substance that is identified in a proposed or final Significant New Use Rule T - Indicates a substance that is the subject of a Section 4 test rule under TSCA. XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B). Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater. Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants that comprises one of the eligibility criteria for the exemption rule. U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313 Component CAS-No Weight % SARA 313 - Threshold Values % Hexane 110-54-3 >95 1.0 SARA 311/312 Hazard Categories See section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors Hexane X - OSHA Occupational Safety and Health Administration Not applicable CERCLA This material, as supplied, contains one or more substances regulated as a hazardous substance under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) Component Hazardous Substances RQs CERCLA EHS RQs Hexane 5000 lb - California Proposition 65 This product does not contain any Proposition 65 chemicals U.S. State Right-to-Know Regulations Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island ______________________________________________________________________________________________ Page 7 / 8 379 n-Hexane Revision Date 19-Jan-2018 Hexane X U.S. Department of Transportation Reportable Quantity (RQ): Y DOT Marine Pollutant N DOT Severe Marine Pollutant N U.S. Department of Homeland Security This product does not contain any DHS chemicals. Other International Regulations Mexico - Grade Serious risk, Grade 3 16. Other information Prepared By Regulatory Affairs Thermo Fisher Scientific Email: EMSDS.RA@thermofisher.com Creation Date 26-Oct-2009 Revision Date 19-Jan-2018 Print Date 19-Jan-2018 Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard replacing the current legislation under 29 CFR 1910.1200 to align with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text End of SDS ______________________________________________________________________________________________ Page 8 / 8 380 SIGMA-ALDRICH sigma-aldrich.com according to Regulation (EC) No. 1907/2006 Version 6.1 Revision Date 06.02.2017 Print Date 19.02.2019 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifiers Product name : Pyridine Product Number : 270970 Brand : Sigma-Aldrich Index-No. : 613-002-00-7 REACH No. : 01-2119493105-40-XXXX CAS-No. : 110-86-1 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA 1.4 Emergency telephone number Emergency Phone # : +91 98802 05043 SECTION 2: Hazards identification 2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Dermal (Category 4), H312 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 For the full text of the H-Statements mentioned in this Section, see Section 16. 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled. H315 Causes skin irritation. H319 Causes serious eye irritation. Sigma-Aldrich - 270970 Page 1 of 8 381 Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. P403 + P235 Store in a well-ventilated place. Keep cool. Supplemental Hazard none Statements 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. SECTION 3: Composition/information on ingredients 3.1 Substances Formula : C<SB>5</>H<SB>5</>N Molecular weight : 79.10 g/mol CAS-No. : 110-86-1 EC-No. : 203-809-9 Index-No. : 613-002-00-7 Registration number : 01-2119493105-40-XXXX Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration Pyridine CAS-No. 110-86-1 Flam. Liq. 2; Acute Tox. 4; <= 100 % EC-No. 203-809-9 Skin Irrit. 2; Eye Irrit. 2; H225, Index-No. 613-002-00-7 H302, H332, H312, H315, H319 For the full text of the H-Statements mentioned in this Section, see Section 16. SECTION 4: First aid measures 4.1 Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available Sigma-Aldrich - 270970 Page 2 of 8 382 SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Dry powder Dry sand Unsuitable extinguishing media Do NOT use water jet. 5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx) 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information Use water spray to cool unopened containers. SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. 6.3 Methods and materials for containment and cleaning up Large spills should be collected mechanically (remove by pumping) for disposal. Ventilate the area.Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations (see section 13). 6.4 Reference to other sections For disposal see section 13. SECTION 7: Handling and storage 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Keep in a cool, well-ventilated place. Handle and store under inert gas. Storage class (TRGS 510): Flammable liquids 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated Sigma-Aldrich - 270970 Page 3 of 8 383 SECTION 8: Exposure controls/personal protection 8.1 Control parameters 8.2 Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Splash contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 219 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties a) Appearance Form: liquid Colour: colourless b) Odour unpleasant c) Odour Threshold No data available d) pH 8.5 at 15.82 g/l at 25 °C Sigma-Aldrich - 270970 Page 4 of 8 384 e) Melting point/freezing Melting point/range: -42 °C - lit. point f) Initial boiling point and 115 °C - lit. boiling range g) Flash point 17.0 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower Upper explosion limit: 12.4 %(V) flammability or Lower explosion limit: 1.8 %(V) explosive limits k) Vapour pressure 10.0 mmHg at 13.2 °C 20.0 mmHg at 25.0 °C l) Vapour density No data available m) Relative density 0.978 g/cm3 at 25 °C n) Water solubility soluble o) Partition coefficient: n- log Pow: 0.65 octanol/water p) Auto-ignition 482.0 °C temperature q) Decomposition No data available temperature r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information No data available SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid Heat, flames and sparks. 10.5 Incompatible materials Strong oxidizing agents, Strong acids 10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5 Sigma-Aldrich - 270970 Page 5 of 8 385 SECTION 11: Toxicological information 11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - 891.0 mg/kg(Pyridine) Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Ptosis. Behavioral:Somnolence (general depressed activity). Behavioral:Coma. LC50 Inhalation - Rat - 4 h - 5400 ppm(Pyridine) LC50 Inhalation - Rat - 1 h - 28,500 mg/m3(Pyridine) Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Lacrimation. Behavioral:Somnolence (general depressed activity). Lungs, Thorax, or Respiration:Dyspnea. LD50 Dermal - Rabbit - 1,121 mg/kg(Pyridine) Remarks: Behavioral:Ataxia. Gastrointestinal:Changes in structure or function of salivary glands. Liver:Other changes. Skin corrosion/irritation Skin - Rabbit(Pyridine) Result: Mild skin irritation - 24 h (Draize Test) Serious eye damage/eye irritation No data available(Pyridine) Respiratory or skin sensitisation No data available(Pyridine) Germ cell mutagenicity No data available(Pyridine) Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No data available(Pyridine) Specific target organ toxicity - single exposure No data available(Pyridine) Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available(Pyridine) Additional Information RTECS: UR8400000 burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Dizziness, tachycardia, nervousness, insomnia, Skin disorders, loss of appetite(Pyridine) To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Pyridine) Bone marrow - (Pyridine) SECTION 12: Ecological information 12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 93.80 mg/l - 96 h(Pyridine) LC50 - Cyprinus carpio (Carp) - 26.00 mg/l - 96 h(Pyridine) Sigma-Aldrich - 270970 Page 6 of 8 386 Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 940.00 mg/l - 48 h(Pyridine) other aquatic invertebrates EC50 - Daphnia magna (Water flea) - 1,140.00 mg/l - 48 h(Pyridine) EC50 - Daphnia pulex (Water flea) - 520.00 mg/l - 48 h(Pyridine) Toxicity to algae EC50 - SELENASTRUM - 100.00 - 180.00 mg/l - 72 h(Pyridine) 12.2 Persistence and degradability Biodegradability aerobic - Exposure time 28 d(Pyridine) Result: 97 % - Readily biodegradable. 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available(Pyridine) 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Other adverse effects Harmful to aquatic life. SECTION 13: Disposal considerations 13.1 Waste treatment methods Product Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself. Offer surplus and non-recyclable solutions to a licensed disposal company. Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information 14.1 UN number ADR/RID: 1282 IMDG: 1282 IATA: 1282 14.2 UN proper shipping name ADR/RID: PYRIDINE IMDG: PYRIDINE IATA: Pyridine 14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3 14.4 Packaging group ADR/RID: II IMDG: II IATA: II 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user No data available SECTION 15: Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Sigma-Aldrich - 270970 Page 7 of 8 387 15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. H225 Highly flammable liquid and vapour. H302 Harmful if swallowed. H302 + H312 + Harmful if swallowed, in contact with skin or if inhaled. H332 H312 Harmful in contact with skin. H315 Causes skin irritation. H319 Causes serious eye irritation. H332 Harmful if inhaled. Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma- aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale. Sigma-Aldrich - 270970 Page 8 of 8 388 Annexure-IX NABET-QCI Certificate 389 Annexure-X Undertaking from Consultant 390 Annexure-XI Copy of Terms of Reference (TOR) 391 392 393 394 395 396 397 398 399 400 401