Coccidiosis Vaccines

SECTION 2: Hazards identification

EMERGENCY OVERVIEW Yellow-brown Liquid Odor unknown Causes cancer. Mutagen. Toxic by inhalation, skin absorption or if swallowed. May cause impaired fertility. May cause developmental effects. May cause sensitization by inhalation or skin contact. May be irritating to eyes, skin or respiratory tract. Prolonged exposure may cause serious health effects. May cause effects to: respiratory system gastrointestinal tract liver kidney reproductive system fetus Toxic to fish and aquatic organisms. May cause long-term adverse effects in the aquatic environment.

Potential health effects

The toxicological properties of the mixture(s) have not been fully characterized in humans or animals. However, there are data to describe the toxicological properties of the individual ingredients. The following summary is based upon available information about the individual ingredients of the mixture(s), or of the expected properties of the mixture(s). Potassium dichromate is corrosive to any tissue with which it comes into contact. Acute inhalation of the dust or mist can produce irritation of the nose, eyes, and respiratory tract, sneezing, throat redness, nasal septum lesions, or bronchospasm. Portassium dichromate can be absorbed by any exposure route and may cause systemic effects. Acute effects that may result from ingestion include abdominal and esophageal pain, vomiting, gastrointestinal bleeding, respiratory distress, cyanosis, coma, and death. Potassium dichromate is a common skin sensitizer following repeated exposure. Chronic skin contact may produce allergic contact dermatitis with deep ulcers. Long-term inhalation exposure to potassium dichromate may cause chronic rhinitis, coughing, wheezing, dyspnea, asthma, perforation of the nasal septum, and mucous membrane injury. Hexavalent chromium, class of compounds to which potassium dichromate belongs, have been shown to cause liver and kidney damage with chronic occupational exposure. Epidemiological studies have consistently shown excess risks for lung cancer in workers involved in chromate or chromate pigment production. The epidemiological studies do not clearly implicate specific chromium compounds, but implicate the class of hexavalent chromium {chromium [VI]) compounds, to which potassium dichromate belongs. IARC has concluded that there is sufficient evidence in humans for the carcinogenicity of hexavalent chromium compounds. Hexavalent chromium compounds have also been shown to be consistently genotoxic in various studies and assays, and causes developmental and reproductive effects in animals. LISTED CARCINOGENS Potassium dichromate: IARC has classified potassium dichromate as a Group 1 (carcinogenic to humans). Chromium [VI] Compounds: ACGIH has classified chromium [VI] compounds as Group AI (confirmed human carcinogen), and NTP has classified the compounds as Group K (known to be a human carcinogen).