Vitamin D2 (6,19,19-d3)

SECTION 2: Hazards identification

CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 4 Body Contact: 3 Min/Nil=0 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 3 Extreme=4 CANADIAN

Potential Acute Health Effects

SWALLOWED Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual. Small amounts of Vitamin D are safe when ingested but toxic effects can occur after taking very large amounts. These include loss of appetite and weight, thirst, headache, dizziness, nausea and vomiting, increased urination, sweating and tiredness. <\p>. EYE Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. <\p>. SKIN Skin contact with the material may produce toxic effects; systemic effectsmay result following absorption. The material is not thought to be a skin irritant (as classified using animal models). Abrasive damage however, may result from prolonged exposures. <\p>. Open cuts, abraded or irritated skin should not be exposed to this material. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED Inhalation of dusts, generated by the material, during the course of normal handling, may produce severely toxic effects; these may be fatal. The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of dusts, or fume, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.

Potential chronic health

Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. There is some evidence to provide a presumption that human exposure to the material may result in impaired fertility on the basis of: some evidence in animal studies of impaired fertility in the absence of toxic effects, or evidence of impaired fertility occurring at around the same dose levels as other toxic effects but which is not a secondary non-specific consequence of other toxic effects. There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects. Primary hyperparathyroidism and renal impairment may be complicating factors associated with hypercalcaemia (elevated blood-borne levels of calcium). Exposure to the material for prolonged periods may cause physical defects in the developing embryo (teratogenesis). Prolonged administration of large amounts of ergocalciferol can lead to toxic effects. Blood calcium levels are raised; nervousness, headache, nausea and vomiting, gastrointestinal upset, dry mouth and abdominal cramp may be present at first with itching, thirst, pins and needles and pain in the muscle and bone. <\p>. of overdose include an increase in serum and urinary calcium and phosphorus and the deposition of calcium in tissues including arteries and kidneys. This may lead to hypertension and renal failure. Cholesterol concentrations in plasma may also increase.