Tributyl(vinyl)stannane

SECTION 2: Hazards identification

CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 3 Body Contact: 2 Min/Nil=0 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 2 Extreme=4 CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK Harmful in contact with skin. Toxic if swallowed. Toxic: danger of serious damage to health by prolonged exposure through inhalation and if swallowed. Irritating to eyes and skin. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Potential Acute Health Effects

SWALLOWED Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual. Subchronic exposures to mono-, di- and tri- and tetra-substituted organotin compounds may elicit toxic response in the central nervous, immune and renal systems, the liver and bile duct and the skin. Some trialkyl organotin compounds cause damage to the central nervous system, consisting of swelling through the white matter. Lighter functional groups cause a more potent response. <\p>. EYE This material can cause eye irritation and damage in some persons. Organotin compounds may be strong irritants, and acute conjunctivitis may result from eye splashes, even when followed by immediate lavage; corneal opacities have also been observed. SKIN Skin contact with the material may be harmful; systemic effects may resultfollowing absorption. This material can cause inflammation of the skin oncontact in some persons. The material may accentuate any pre-existing dermatitis condition. Irritation following contact with organotin compounds may be delayed, in certain cases chemical burns and dermatitis may result. Rate of absorption may be increased if product is in solution. Open cuts, abraded or irritated skin should not be exposed to this material. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. Trialkyl organotin compounds are well absorbed through the skin; healing is slow and skin burns result. The lower abdomen, thighs and groin are most often affected due to absorption by clothing. INHALED The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of vapors, fumes or aerosols, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress. Inhalation of aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the health of the individual. The acute toxicity of inhaled organotin compounds resembles that foundby other means of exposure.

Potential chronic health

Toxic: danger of serious damage to health by prolonged exposure through inhalation and if swallowed. This material can cause serious damage if one is exposed to it for long periods. It can be assumed that it contains a substance which can produce severe defects. <\p>. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Both tributyltins (TBT) and dibutyltins (DBT) have negative effects on the reproductive system in mammals. In line with these facts, TBT and TPT were given the highest category in a European review of endocrine disrupting chemicals (BKH, 2000): “Evidence for endocrine disruption in living organisms”. TBT was also classified as “Evidence of potential to cause endocrine disruption in humans”. Organotins are also toxic by other mechanisms. For instance, several organotins are strongly immunosuppressive, display developmental and reproductive effects and are neurotoxic TPT is classified as category 3 carcinogenic in the EU, but as category 2 (probable human carcinogenic) by the USEPA (EFSA, 2004). DBT may actually be more toxic than TBT to certain enzyme systems. Immunotoxic and developmental effects in mammals may also be more sensitive to DBT than to TB. Both TBT and TPT may be classified as Persistent, Bioaccumulative and Toxic (PBT) and very Persistent,very Bioaccumulative (vPvB) substances according to certain, whereas DBT and dioctyl tin (DO)T may be classified as PBT For human health, there are no epidemiological studies on chronic low level exposure available It has been suggested that toxicity was equal for DBT, TBT, DOT and TPT for humans, and proposed a group TDI of 0.1 ìg Sn (kg Bw and d)-1.