Terephthaloyl chloride

SECTION 2: Hazards identification

CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 2 Body Contact: 3 Min/Nil=0 Low=1 Reactivity: 1 CANADIAN WHMIS SYMBOLS 1 of 11 EMERGENCY OVERVIEW RISK Harmful if swallowed. Causes burns. Risk of serious damage to eyes.

Potential Acute Health Effects

SWALLOWED Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion. Ingestion of acidic corrosives may produce burns around and in the mouth. the throat and esophagus. EYE The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating. If applied to the eyes, this material causes severe eye damage. Irritation of the eyes may produce a heavy secretion of tears (lachrymation). Direct eye contact with acid corrosives may produce pain, tears, sensitivity to light and burns. Mild burns of the epithelia generally recover rapidly and completely. SKIN The material can produce chemical burns following direct contactwith the skin. Skin contact is not thought to produce harmful health effects (as classified using animal models). Systemic harm, however, has been identified following exposure of animals by at least one other route and the material may still produce health damage following entry through wounds, lesions or abrasions. Open cuts, abraded or irritated skin should not be exposed to this material. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. Skin contact with acidic corrosives may result in pain and burns; these may be deep with distinct edges and may heal slowly with the formation of scar tissue. INHALED If inhaled, this material can irritate the throat andlungs of some persons. Inhalation of dusts, generated by the material during the course of normal handling, may be damaging to the health of the individual. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. Hydrogen chloride (HCl) vapour or fumes present a hazard from a single acute exposure. Exposures of 1300 to 2000 ppm have been lethal to humans in a few minutes. Corrosive acids can cause irritation of the respiratory tract, with coughing, choking and mucous membrane damage. There may be dizziness, headache, nausea and weakness.

Potential chronic health

Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Chronic minor exposure to hydrogen chloride (HCl) vapour or fume may cause discolouration or erosion of the teeth, bleeding of the nose and gums; and ulceration of the nasal mucous membranes. Repeated exposures of animals to concentrations of about 34 ppm HCl produced no immediate toxic effects. Workers exposed to hydrochloric acid suffered from gastritis and a number of cases of chronic bronchitis have also been reported. Repeated or prolonged exposure to dilute solutions of HCl may cause dermatitis. Repeated or prolonged exposure to acids may result in the erosion of teeth, swelling and or ulceration of mouth lining. Irritation of airways to lung, with cough, and inflammation of lung tissue often occurs.