Sodium succinate dibasic hexahydrate

SECTION 2: Hazards identification

CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 0 Body Contact: 2 Min/Nil=0 Low=1 Reactivity: 1 CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW 1 of 7 RISK Irritating to eyes, respiratory system and skin.

Potential Acute Health Effects

SWALLOWED The material has NOT been classified as "harmful by ingestion". This is because of the lack of corroborating animal or human evidence. EYE This material can cause eye irritation and damage in some persons. SKIN This material can cause inflammation of the skin oncontact in some persons. The material may accentuate any pre-existing dermatitis condition. Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions. Open cuts, abraded or irritated skin should not be exposed to this material. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.

Potential chronic health

Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. In an experimental study on cats, the oral administration of 0.5 gram per kg daily for several weeks, produced no general signs of poisoning or impairment of nutrition, and no toxic effects on the blood, the liver or the kidney. Indications are that the succinate ion is substantially inert. [Journal of the American Pharmaceutical Association, Vol.32]