Quinuclidine

SECTION 2: Hazards identification

CHEMWATCH HAZARD RATINGS Min Max Flammability 1 Toxicity 3 Min/Nil=0 Body Contact 3 Low=1 Reactivity Moderate=2 1 High=3 Chronic 2 Extreme=4 CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK Causes burns. Risk of serious damage to eyes. Toxic in contact with skin and if swallowed.

Potential Acute Health Effects

SWALLOWED ! Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual. ! The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion. EYE ! The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating. ! If applied to the eyes, this material causes severe eye damage. SKIN ! Skin contact with the material may produce toxic effects; systemic effects may result following absorption. ! The material can produce chemical burns following direct contactwith the skin. ! Open cuts, abraded or irritated skin should not be exposed to this material. ! Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. ! Solution of material in moisture on the skin, or perspiration, may markedly increase skin corrosion and accelerate tissue destruction. INHALED ! If inhaled, this material can irritate the throat andlungs of some persons. ! Inhalation of dusts, generated by the material during the course of normal handling, may be damaging to the health of the individual. ! Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. If prior damage to the circulatory or nervous systems has occurred or if kidney damage has been sustained, proper screenings should be conducted on individuals who may be exposed to further risk if handling and use of the material result in excessive exposures.

Potential chronic health

! Repeated or prolonged exposure to corrosives may result in the erosion of teeth, inflammatory and ulcerative changes in the mouth and necrosis (rarely) of the jaw. Bronchial irritation, with cough, and frequent attacks of bronchial pneumonia may ensue. Gastrointestinal disturbances may also occur. Chronic exposures may result in dermatitis and/or conjunctivitis. Substance accumulation, in the human body, may occur and may cause some concern following repeated or long-term occupational exposure. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray.