Platinum(II) acetylacetonate

SECTION 2: Hazards identification

CHEMWATCH HAZARD RATINGS Min Max Flammability 1 Toxicity 2 Min/Nil=0 Body Contact 2 Low=1 Reactivity Moderate=2 1 High=3 Chronic 2 Extreme=4 CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK May cause SENSITISATION by skin contact. Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Harmful to aquatic organisms.

Potential Acute Health Effects

SWALLOWED ■ Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. ■ Platinoids are poorly absorbed from the gut, skin and other routes not directly in the blood stream. More is absorbed if inhaled, and the substance is lodged in the lungs and airway. ■ Ingestion of 2,4-pentanedione (acetylacetone) may cause irritation of the mouth, gullet and stomach, abdominal discomfort, nausea, vomiting, diarrhoea, dizziness, malaise and fainting. ■ At sufficiently high doses the material may be neurotoxic (i. e. EYE ■ There is some evidence to suggest that this material can cause eye irritation and damage in some persons. ■ Exposure to 2, 4-pentadione may produce excessive redness of the eyes and swelling of the conjunctiva, blinking and tearing. However, corneal damage is unlikely. SKIN ■ Skin contact with the material may be harmful; systemic effects may result following absorption. ■ The material may cause mild but significant inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterised by redness, swelling and blistering. ■ Open cuts, abraded or irritated skin should not be exposed to this material. ■ 2,4-Pentadione may produce acute itchy rash, skin inflammation, reddening, pain and allergic rashes. Prolonged contact may cause burns, ulceration and bleeding. ■ Platinum and its compounds produce marked irritation to the skin, eyes and respiratory system. Contact allergic dermatitis may also result. ■ Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED ■ Inhalation of dusts, generated by the material, during the course of normalhandling, may be harmful. ■ There is some evidence to suggest that the material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. ■ Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. If prior damage to the circulatory or nervous systems has occurred or if kidney damage has been sustained, proper screenings should be conducted on individuals who may be exposed to further risk if handling and use of the material result in excessive exposures. ■ At sufficiently high doses the material may be neurotoxic (i. e. ■ High or repeated doses of 2,4-pentanedione produced difficulty in breathing, brain disease and central nervous system depression with damage to the thymus in experimental animals. Inhalation of its vapours may cause unconsciousness.

Potential chronic health

■ Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems. Skin contact with the material is more likely to cause a sensitisation reaction in some persons compared to the general population. Substance accumulation, in the human body, may occur and may cause some concern following repeated or long-term occupational exposure. There is some evidence that inhaling this product is more likely to cause a sensitisation reaction in some persons compared to the general population. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Repeated overexposure to 200 ppm 2,4-pentanedione vapour may result in inflammation of the nasal mucosa. Higher concentrations may produce central nervous system effects, and immune system and bone marrow deficits. Recurrent exposure to high concentrations of the 2,4-pentadione vapour (~650 ppm) produces lethal degenerative lesions in the central nervous system and thymus. Exposure in pregnancy can cause damage to the foetus. Platinum salt complexes can cause immediate hypersensitivity reactions either by contact or inhalation known as "platinosis". Symptoms include asthma, runny nose, inflammation of skin, eczema and hives, cough, inflammation of the nose and throat, difficulty breathing, itching, and dilation of the blood vessels of the conjunctiva.