4-Aminoantipyrine

SECTION 2: Hazards identification

CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 2 Body Contact: 2 Min/Nil=0 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 2 Extreme=4 CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK Harmful if swallowed. Irritating to eyes, respiratory system and skin. Cumulative effects may result following exposure*. * (limited evidence).

Potential Acute Health Effects

SWALLOWED ■ Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. EYE ■ This material can cause eye irritation and damage in some persons. SKIN ■ This material can cause inflammation of the skin oncontact in some persons. ■ The material may accentuate any pre-existing dermatitis condition. ■ Open cuts, abraded or irritated skin should not be exposed to this material. ■ Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED ■ The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. ■ Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. If prior damage to the circulatory or nervous systems has occurred or if kidney damage has been sustained, proper screenings should be conducted on individuals who may be exposed to further risk if handling and use of the material result in excessive exposures.

Potential chronic health

■ Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems. Substance accumulation, in the human body, may occur and may cause some concern following repeated or long-term occupational exposure. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. The material has antipyretic and analgesic properties. A similar material, amidopyrine CAS 58-15-1 is considered a potential carcinogen because it reacts readily with nitrous acid to form dimethylnitrosoamine. The reaction was catalysed by thiocyanate present in the saliva, particularly in smokers. In addition this compound is involved in the development of agranulocytosis.