3-Ethynylaniline

SECTION 2: Hazards identification

CHEMWATCH HAZARD RATINGS Min Max Flammability: 2 Toxicity: 2 Body Contact: 2 Min/Nil=0 Low=1 Reactivity: 1 CANADIAN WHMIS SYMBOLS 1 of 7 EMERGENCY OVERVIEW RISK Harmful if swallowed. May cause SENSITISATION by skin contact. Irritating to eyes, respiratory system and skin. Flammable. Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Potential Acute Health Effects

SWALLOWED Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. The substance and/or its metabolites may bind to hemoglobin inhibiting normal uptake of oxygen. This condition, known as "methemoglobinemia", is a form of oxygen starvation (anoxia). EYE This material can cause eye irritation and damage in some persons. SKIN This material can cause inflammation of the skin oncontact in some persons. The material may accentuate any pre-existing dermatitis condition. Open cuts, abraded or irritated skin should not be exposed to this material. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. Inhalation hazard is increased at higher temperatures.

Potential chronic health

Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems. Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Most arylamines are powerful poisons to the blood-making system. High chronic doses cause congestion of the spleen and tumor formation. The material induced mutations in the Ames test using salmonella strains in the presence of rat liver metabolic activation preparations.