Note: Ingredients listed on restricted chemical lists
EC/CAS
69-65-8
Name of the chemical
D-mannitol C6H14O6
Concentration
N/A
EC/CAS
7732-18-5
Name of the chemical
Water, distilled, conductivity or of similar purity H2O
Concentration
N/A
General Information
Product name
Topotecan HCl
Chemical name
(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H- pyrano[3’,4’:6,7] indolizino [1,2-b]quinoline-3,14- (4H,12H)-dione monohydrochloride
1.2.1 Relevant identified uses
Anti-tumor
Icons in SDS
Company Information
company name
Sagent Pharmaceuticals, Inc.
GHS Information
Signal word
-
Hazard Codes
Hazard statements (CLP)
H303
Hazard statements
Code
Statements
H303
May be harmful if swallowed
Section 2
SECTION 2: Hazards identification
NFPA Rating Classification
Health hazards
Flammability Instability Other Not Available HMIS Rating (Chronic Hazard) Flammability Hazard WARNING! THIS PRODUCT CONTAINS A CYTOTOXIC AGENT EXPOSURE BY ALL ROUTES OF EXPOSURE MUST BE AVOIDED In the workplace, this product may cause irritation by all routes of exposure. May be harmful if swallowed. In therapeutic use this product can cause bone marrow suppression which can lead to serious infection or death. The most common non-hematologic adverse reactions were nausea, alopecia, vomiting, sepsis or pyrexia/infection with neutropenia, diarrhea, constipation, fatigue, and fever. Can cause fetal harm. Hypersensitivity reactions have been reported from therapeutic use. Suspected of carcinogenic and mutagenic effects, based on animal and microorganism test data. These effects may be possible as a result of workplace exposure. Refer to Section 11 (Toxicological Information) for additional information on adverse effects. Flammability Hazards: This solution is not flammable or combustible. When involved in a fire, this material may decompose and produce irritating vapors and toxic compounds, including carbon and nitrogen oxides and hydrogen chloride. Reactivity Hazards: This product is not reactive.
Physical hazards
Signal Word, Hazard Description of Hazards statement(s), Symbol(s), and/or Precautionary
Signal word
- DANGER
Hazard statements
- May damage the unborn child - May cause genetic defects EMERGENCY OVERVIEW
Product definition
This product is a clear, light yellow to greenish solution, odorless solution
Environmental hazards
Large quantities released to the aquatic and terrestrial environment may have an adverse effect. No data are available. Emergency Considerations: Emergency responders should wear appropriate protection for the situation to which they respond. (d) Unknown Acute Toxicity: N/A
2.1 Classification of the substance or mixture
US OSHA: May damage the unborn child. May cause genetic defects. NFPA Rating Health Hazard 2 Flammability 0 Instability 0 Other Not Available HMIS Rating Health Hazard 2 (Chronic Hazard) Flammability Hazard 0 Physical Hazard 0 (b) Signal Word, Hazard (c) Description of Hazards
