ROTI Aqua-P/C/I , ready-to-use, for RNA extrac- tion

Hazard statements (CLP)

H301, H301+H331, H312, H314, H318, H331, H341, H351, H361d, H372, H411

Code

Statements

H301

Toxic if swallowed

SECTION 2: Hazards identification

According to Regulation (EC) No 1272/2008 [CLP Classification of the substance or mixture

Hazard categories

Cat- Hazard class and Hazard egory category statement 3.1O Acute toxicity (oral) Acute Tox. 3 H301 3.1D Acute toxicity (dermal) Acute Tox. 4 H312 3.1I Acute toxicity (inhal.) Acute Tox. 3 H331 3.2 Skin corrosion/irritation 1B Skin Corr. 1B H314 3.3 Serious eye damage/eye irritation Eye Dam. 1 H318 3.5 Germ cell mutagenicity Muta. 2 H341 3.6 Carcinogenicity Carc. 2 H351 3.7 Reproductive toxicity Repr. 2 H361d 3.9 Specific target organ toxicity - repeated exposure STOT RE 1 H372 4.1C Hazardous to the aquatic environment - chronic hazard Aquatic Chronic 2 H411 For full text of abbreviations: see SECTION 16

Most important adverse effects

Skin corrosion produces an irreversible damage to the skin; namely, visible necrosis through the epi- dermis and into the dermis. Delayed or immediate effects can be expected after short or long-term exposure. Spillage and fire water can cause pollution of watercourses

Signal word

Danger Danger Not required

Hazard pictograms

GHS05, GHS06, GHS08, GHS09 H301+H331 Toxic if swallowed or if inhaled. H314 Causes severe skin burns and eye damage. H341 Suspected of causing genetic defects. H351 Suspected of causing cancer. H361d Suspected of damaging the unborn child. H372 Causes damage to organs (kidney, liver) through prolonged or repeated exposure. P201 Obtain special instructions before use. P280 Wear protective clothing/eye protection/face protection. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 IF exposed or concerned: Get medical advice/attention.

Hazard statements

H301+H331 Toxic if swallowed or if inhaled H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H341 Suspected of causing genetic defects H351 Suspected of causing cancer H361d Suspected of damaging the unborn child H372 Causes damage to organs (kidney, liver) through prolonged or repeated expos- ure H411 Toxic to aquatic life with long lasting effects Not required

Prevention

P201 Obtain special instructions before use P280 Wear protective clothing/eye protection/face protection

Response

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P308+P313 IF exposed or concerned: Get medical advice/attention For professional users only

Hazardous Ingredients

Trichloromethane, Phenol, Isoamyl alcohol Labelling of packages where the contents do not exceed 125 ml

Contains

Trichloromethane, Phenol, Isoamyl alcohol Labelling of packages where the contents do not exceed 10 ml

Precautionary statements

Not required

Results of PBT and vPvB assessment

Does not contain a PBT-/vPvB-substance at a concentration of ≥ 0,1%. Endocrine disrupting properties Does not contain an endocrine disruptor (ED) at a concentration of ≥ 0,1%.

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 (CLP) Section Hazard class Cat- Hazard class and Hazard egory category statement 3.1O Acute toxicity (oral) 3 Acute Tox. 3 H301 3.1D Acute toxicity (dermal) 4 Acute Tox. 4 H312 3.1I Acute toxicity (inhal.) 3 Acute Tox. 3 H331 3.2 Skin corrosion/irritation 1B Skin Corr. 1B H314 3.3 Serious eye damage/eye irritation 1 Eye Dam. 1 H318 3.5 Germ cell mutagenicity 2 Muta. 2 H341 3.6 Carcinogenicity 2 Carc. 2 H351 3.7 Reproductive toxicity 2 Repr. 2 H361d 3.9 Specific target organ toxicity - repeated exposure 1 STOT RE 1 H372 4.1C Hazardous to the aquatic environment - chronic hazard 2 Aquatic Chronic 2 H411 For full text of abbreviations: see SECTION 16 The most important adverse physicochemical, human health and environmental effects Skin corrosion produces an irreversible damage to the skin; namely, visible necrosis through the epi- dermis and into the dermis. Delayed or immediate effects can be expected after short or long-term exposure. Spillage and fire water can cause pollution of watercourses.