Endpoproteinase Arg-C

Roche Diagnostics Deutschland GmbH

Revision date : 2026-05-27

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GHS08
Health risk rating 5
Safety risk rating 1
Environmental risk rating 1

Note: Ingredients listed on restricted chemical lists

EC/CAS

233-140-8/10043-52-4

Name of the chemical

calcium chloride

Concentration

>=10-<20

General Information

Revision date

2026-05-27

Product name

Endpoproteinase Arg-C

1.2.1 Relevant identified uses

Laboratory chemicals, Refer to product literature for further details

Emergency telephone

+49(0)621-759-2203, +49(0)6131-19240

Icons in SDS

GHS08 M004 M009 M010 M013

Company Information

company name

Roche Diagnostics Deutschland GmbH

e-mail address of the competent person responsible for the Safety Data Sheet

info.dia-sds@roche.com

GHS Information

Signal word

Danger

Hazard Codes

Hazard statements (CLP)

H319, H334, H373

Hazard statements

Code

Statements

H319

Causes serious eye irritation

Section 2

SECTION 2: Hazards identification

Regulation (EC) No. 1272/2008 Classification of the substance or mixture

Signal word

Danger

Hazard statements

H319 Causes serious eye irritation. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H373 May cause damage to organs through prolonged or repeated exposure.

Precautionary statements

P260 Do not breathe dust. P280 Wear eye protection/ face protection. P284 Wear respiratory protection.

Response

P304 + P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P337 + P313 If eye irritation persists: Get medical advice/ attention. P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/ doctor.

Hazardous Ingredients

Disodium dihydrogen ethylenediaminetetraacetate Endoproteinase Arg-C

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

2.1 Classification of the substance or mixture

Classification (REGULATION (EC) No 1272/2008) as amended by GB-CLP Regulation, UK SI 2019/720, and UK SI 2020/1567) Eye irritation, Category 2 H319: Causes serious eye irritation. Respiratory sensitisation, Category 1 H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled. Specific target organ toxicity - repeated H373: May cause damage to organs through exposure, Category 2 prolonged or repeated exposure. 2.2 Label elements Labelling (REGULATION (EC) No 1272/2008) as amended by GB-CLP Regulation, UK SI 2019/720, and UK SI 2020/1567) Hazard pictograms : Signal word : Danger Hazard statements : H319 Causes serious eye irritation. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H373 May cause damage to organs through prolonged or repeated exposure. Prevention: Precautionary statements : P260 Do not breathe dust. P280 Wear eye protection/ face protection. P284 Wear respiratory protection. Response: P304 + P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P337 + P313 If eye irritation persists: Get medical advice/ attention. P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/ doctor. Hazardous components which must be listed on the label: Disodium dihydrogen ethylenediaminetetraacetate Endoproteinase Arg-C 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. SECTION 3: Composition/information on ingredients 3.2 Mixtures Components Chemical name CAS-No. Classification Concentration EC-No. (% w/w) Index-No. Registration number Disodium dihydrogen 139-33-3 Acute Tox. 4; H332 >= 10 - < 20 ethylenediaminetetraacetate 205-358-3 STOT RE 2; H373 (Respiratory Tract) Calcium chloride 10043-52-4 Eye Irrit. 2; H319 >= 10 - < 20 233-140-8 017-013-00-2 01-2119494219-28

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