TOLUENE

Hazard statements (CLP)

H225, H304, H315, H336, H361, H373

Code

Statements

H225

Highly Flammable liquid and vapour

SECTION 2: Hazards identification

OSHA Classification of the substance/mixture: Hazard class and category code

Hazard categories

Health Environmental Physical Aspiration toxicity category 1 Aquatic Toxicity Flammable – Skin irritation: Category 2 Category 1 Category 2 Reproductive/Developmental – Category 2 Flammable liquid Specific Target Organ Toxicity (RE) 2 NA: Not available, RE: Repeated Exposure GHS Category table for reference Study/hazard Category 1 Category 2 Category 3 Category 4 Category 5 statement Acute Oral mg/kg < 50 mg/kg 50 < 300 300 < 2000 2000 LD50 Fatal if swallowed mg/kg 5000mg/kg Toxic if swallowed Harmful if May be harmful if swallowed Acute Dermal 50 mg/kg 50 < 200 mg/kg 200 < 1000 1000 < 2000 < 5000 LD50 Fatal in contact with Fatal in contact mg/kg 2000 mg/kg mg/kg May be skin with skin Toxic in contact Harmful in harmful in with skin contact with skin contact with skin Acute Inhalation See footnote Dust LC50 below this Gases LC50 0.05 mg/L 0.05 < 0.5 mg/L 0.5< 1 mg/L 1.0< 5 mg/L table Vapours LC50 100 ppm/V 100 < 500 500 < 2500 2500 < 20000 mg/L ppm/V Fatal if inhaled < 2.0 mg/L 2.0 < 10 mg/L < 20 mg/L Fatal if inhaled Toxic if inhaled Harmful if inhaled Flammable Flash point < 23 Flash point ≥ 23 Flash point ≥ 60 Not Liquids degrees C and initial degrees C and initial degrees C ≤ 60 degrees C ≤ 93 Applicable boiling point < 35 boiling point > 35 degrees C degrees C. Extremely degrees C. Highly Flammable liquid Combustible liquid flammable liquid and flammable liquid and and vapour vapour Note: Gases concentration are expressed in parts per million per volume (ppmV) NOTE 1: Category 5 is for mixtures which are of relatively low acute toxicity but which under certain circumstances may pose a hazard to vulnerable populations. These mixtures are anticipated to have an oral or dermal LD50 value in the range of 2000-5000 mg/kg bodyweight or equivalent dose for other routes of exposure. In light of animal welfare considerations, testing in animals in Category 5 ranges is discouraged and should only be considered when there is a strong likelihood that results of such testing would have a direct relevance for protecting human health NOTE 2: These values are designed to be used in the calculation of the ATE for classification of a mixture based on its ingredients and do not represent test results. The values are conservatively set at the lower end of the range of Categories 1 and 2, and at a point approximately 1/10th from the lower end of the range for Categories 3 – 5 GHS Category table for reference: Continued Study/hazard Category 1 Category 2 Category 3 statement Eye Irritation Effects on the cornea, iris or 2A: Effects on the cornea, iris or Not applicable conjunctiva that are not expected to conjunctiva that fully reverse within 21 reverse or that have not fully days reversed within 21 days Causes severe eye irritation. 2B Causes severe eye damage Effects on the cornea, iris or conjunctiva that fully reverse within days Causes eye irritation Skin Irritation Destruction of skin tissue, with Mean value of >2.3 > 4.0 for erythema / Mean value of >1.5 < 2.3 for sub categorization based on eschar or edema in at least 2 of 3 tested erythema / eschar or edema exposure of up to 3 minutes (A), 1 animals from gradings at 24, 48, and 72 in at least 2 of 3 tested hour (B), or 4 hours (C) hours (or on 3 consecutive days after animals from gradings at 24, Causes severe skin burns and eye onset if reactions are delayed); 48, and 72 hours (or on 3 damage inflammation that persists to end of the consecutive days after onset normally 14-day) observation period if reactions are delayed) Causes skin irritation Causes mild skin irritation

Environmental hazards

96 hr LC50 (fish) <1 mg/L 48 hr 96 hr LC50 (fish) >1< 10 mg/L 48 hr 96 hr LC50 (fish) >10< 100 Acute Toxicity EC50 (crustacea) < 1 mg/L, 72/96 EC50 (crustacea) >1< 10 mg/L 72/96 hr mg/L 48 hr EC50 (crustacea) Category hr ErC50 (aquatic plants) < 1 mg/L ErC50 (aquatic plants) >1< 10 mg/L 10< 100 mg/L 72/96 hr Very toxic to aquatic life Toxic to aquatic life ErC50 (aquatic plants) >10< 100 mg/L Harmful to aquatic life Flammable Extremely flammable aerosol Flammable aerosol Not Applicable Aerosol Flammable Using the burning rate test, Using the burning rate test, substances Not Applicable solids substances or mixtures other than or mixtures other than metal powders metal powders: (a) wetted zone does wetted zone does not stop fire for at not stop fire and least 4 minutes and (b) burning time < burning time < 45 seconds or 45 seconds or burning rate > 2.2 burning rate > 2.2 mm/second mm/second Using the burning rate test, Using the burning rate test, metal metal powders that have burning time > powders that have burning time < 5 < 10 minutes minutes Flammable solid Flammable Gases, which at 20 degrees C and a Gases, other than those of category 1, Not Applicable gases standard pressure of 101.3 kPA: (a) which, at 20 degrees C and a standard are ignitable when in a mixture of pressure of 101.3 kPA, have a 13% or less by volume in air; or (b) flammable range while mixed in air have a flammable range with air of Flammable gas at least 12 percentage points regardless of the lower flammable limit Extremely flammable gas

2.2 Label elements

GHS02 Flame.;GHS08 Carcinogen Details of statements

Hazard statements

H225: Highly flammable liquid and vapour. H304: May be fatal if swallowed and enters airways. H315: Causes skin irritation. H336: May cause dizziness or drowsiness. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage to organs through prolonged or repeated exposure P203: Obtain, read and follow all safety instructions before use. P210: Keep away from heat/sparks/open flames/hot surfaces No smoking. P 233: Keep container tightly closed. P 240: Ground/bond container and receiving equipment. 241: Use explosion-proof electrical/ventilating/lighting/ equipment. P 242: Use only non-sparking tools. P 243: Take precautionary measures against static discharge. Precautionary P 260: Do not breathe dust/fume/gas/mist/vapours/spray. NFPA HAZARD CODES RATINGS SYSTEM HEALTH: 2 0 = No Hazard FLAMMABILITY: 3 1 = Slight Hazard INSTABILITY: 0 2 = Moderate Hazard 3 = Serious Hazard 4 = Severe Hazard Data Reference: https://pubchem.ncbi.nlm.nih.gov/compound/Toluene#section=NFPA-Hazard-

Prevention

P261: Avoid breathing dust/fumes/mist/vapours/spray. P 264: Wash thoroughly after handling. P 270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P271: Use only outdoors or in a well-ventilated area. P301+P316 IF SWALLOWED Get emergency medical help immediately. P302+P352 IF ON SKIN wash with plenty of water P303+P361+P353 IF ON SKIN (or hair) Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower]. P304+P340 IF INHALED Remove person to fresh air and keep comfortable for breathing. P318: if exposed or concerned, get medical advice P319: Get medical help if you feel unwell Precautionary P321: Specific treatment reference to first aid instruction

Response

P331: Do NOT induce vomiting. P332+P317 If skin irritation occurs Get medical help P362+P364: Take off contaminated clothing and wash it before reuse. P370+P378 In case of fire Use dry chemical, carbon dioxide to extinguish P314: Get medical advice/attention if you feel unwell. P332+P313 IF SKIN irritation occurs Get medical advice/attention P337+P313 IF eye irritation persists Get medical advice/attention Precautionary P403+P233: Store in a well-ventilated place. Keep container tightly

Storage

closed P403+P235: Store in a well-ventilated place. Keep cool. P405: Store locked up Precautionary Follow local regulation

Disposal

P501: Dispose of contents/container

2.1 Classification of the substance or mixture

code. GHS Category: Health Environmental Physical Aspiration toxicity category 1 Aquatic Toxicity Flammable – Skin irritation: Category 2 – Category 1 Category 2 Reproductive/Developmental – Category 2 Flammable liquid Specific Target Organ Toxicity (RE) 2 NA: Not available, RE: Repeated Exposure. GHS Category table for reference: Study/hazard Category 1 Category 2 Category 3 Category 4 Category 5 statement Acute Oral < 5 mg/kg > 5 < 50 mg/kg > 50 < 300 > 300 < 2000 > 2000 LD50 Fatal if swallowed mg/kg <5000mg/kg Toxic if swallowed Harmful if May be harmful if swallowed Acute Dermal < 50 mg/kg > 50 < 200 mg/kg > 200 < 1000 > 1000 < > 2000 < 5000 LD50 Fatal in contact with Fatal in contact mg/kg 2000 mg/kg mg/kg May be skin with skin Toxic in contact Harmful in harmful in with skin contact with skin contact with skin Acute Inhalation See footnote Dust LC50 below this Gases LC50 < 0.05 mg/L > 0.05 < 0.5 mg/L > 0.5< 1 mg/L > 1.0< 5 mg/L table Vapours LC50 < 100 ppm/V > 100 < 500 > 500 < 2500 > 2500 < 20000 <0.5 mg/L ppm/V Fatal if inhaled >0.5 < 2.0 mg/L >2.0 < 10 mg/L >10 < 20 mg/L Fatal if inhaled Toxic if inhaled Harmful if inhaled Flammable Flash point < 23 Flash point ≥ 23 Flash point ≥ 60 Not Liquids degrees C and initial degrees C and initial degrees C ≤ 60 degrees C ≤ 93 Applicable boiling point < 35 boiling point > 35 degrees C. degrees C. Extremely degrees C. Highly Flammable liquid Combustible liquid flammable liquid and flammable liquid and and vapour vapour Note: Gases concentration are expressed in parts per million per volume (ppmV). NOTE 1: Category 5 is for mixtures which are of relatively low acute toxicity but which under certain circumstances may pose a hazard to vulnerable populations. These mixtures are anticipated to have an oral or dermal LD50 value in the range of 2000-5000 mg/kg bodyweight or equivalent dose for other routes of exposure. In light of animal welfare considerations, testing in animals in Category 5 ranges is discouraged and should only be considered when there is a strong likelihood that results of such testing would have a direct relevance for protecting human health. NOTE 2: These values are designed to be used in the calculation of the ATE for classification of a mixture based on its ingredients and do not represent test results. The values are conservatively set at the lower end of the range of Categories 1 and 2, and at a point approximately 1/10th from the lower end of the range for Categories 3 – 5. GHS Category table for reference: Continued Study/hazard Category 1 Category 2 Category 3 statement Eye Irritation Effects on the cornea, iris or 2A: Effects on the cornea, iris or Not applicable conjunctiva that are not expected to conjunctiva that fully reverse within 21 reverse or that have not fully days. reversed within 21 days. Causes severe eye irritation. 2B : Causes severe eye damage. Effects on the cornea, iris or conjunctiva that fully reverse within 7 days. Causes eye irritation. Skin Irritation Destruction of skin tissue, with Mean value of >2.3 > 4.0 for erythema / Mean value of >1.5 < 2.3 for sub categorization based on eschar or edema in at least 2 of 3 tested erythema / eschar or edema exposure of up to 3 minutes (A), 1 animals from gradings at 24, 48, and 72 in at least 2 of 3 tested hour (B), or 4 hours (C). hours (or on 3 consecutive days after animals from gradings at 24, Causes severe skin burns and eye onset if reactions are delayed); 48, and 72 hours (or on 3 damage. inflammation that persists to end of the consecutive days after onset (normally 14-day) observation period. if reactions are delayed). Causes skin irritation. Causes mild skin irritation. Environment: 96 hr LC50 (fish) <1 mg/L 48 hr 96 hr LC50 (fish) >1< 10 mg/L 48 hr 96 hr LC50 (fish) >10< 100 Acute Toxicity EC50 (crustacea) < 1 mg/L, 72/96 EC50 (crustacea) >1< 10 mg/L 72/96 hr mg/L 48 hr EC50 (crustacea) Category hr ErC50 (aquatic plants) < 1 mg/L ErC50 (aquatic plants) >1< 10 mg/L >10< 100 mg/L 72/96 hr Very toxic to aquatic life Toxic to aquatic life ErC50 (aquatic plants) >10< 100 mg/L Harmful to aquatic life Flammable Extremely flammable aerosol Flammable aerosol Not Applicable Aerosol Flammable Using the burning rate test, Using the burning rate test, substances Not Applicable solids substances or mixtures other than or mixtures other than metal powders: metal powders: (a) wetted zone does (a) wetted zone does not stop fire for at not stop fire and least 4 minutes and (b) burning time < (b) burning time < 45 seconds or 45 seconds or burning rate > 2.2 burning rate > 2.2 mm/second mm/second Using the burning rate test, Using the burning rate test, metal metal powders that have burning time > powders that have burning time < 5 5 < 10 minutes minutes Flammable solid Flammable Gases, which at 20 degrees C and a Gases, other than those of category 1, Not Applicable gases standard pressure of 101.3 kPA: (a) which, at 20 degrees C and a standard are ignitable when in a mixture of pressure of 101.3 kPA, have a 13% or less by volume in air; or (b) flammable range while mixed in air. have a flammable range with air of Flammable gas at least 12 percentage points regardless of the lower flammable limit. Extremely flammable gas GHS Label: GHS02: Flame.;GHS08 :Carcinogen Details of statements: Hazard Statements H225: Highly flammable liquid and vapour. H304: May be fatal if swallowed and enters airways. H315: Causes skin irritation. H336: May cause dizziness or drowsiness. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage to organs through prolonged or repeated

Other hazards

Highly flammable and easily ignitable substance. Danger of ignition at normal temperature. Readily evaporates and vapours form with air toxic and explosive mixtures heavier than air. Mixtures keep above ground and after ignition they spread fast into far distances. Ignition possible when exposed to hot surfaces, sparks, naked flames and by electrostatic discharges too. The substance is practically insoluble in water, floats on the water level and forms toxic and explosive mixtures above the water level. Risk of explosion if emptied into drains or released into wastewater. Attacks rubber and plastics.

Principle Routes of Exposure

Occupational exposure to toluene can occur through inhalation, dermal contact, and ingestion Skin Contact Skin Absorption Eye Contact Inhalation Ingestion Yes DATA REFERENCE: https://pubchem.ncbi.nlm.nih.gov/compound/Toluene#section

Health hazards

Source NTP listed? IARC cancer review group?