Para Di Ethyl Benzene

Hazard statements (CLP)

H226, H304, H315, H318, H411

Code

Statements

H226

Flammable liquid and vapour

SECTION 2: Hazards identification

OSHA Classification of the substance/preparation: Hazard class and category code. GHS Category Health Environmental Physical Irritating to eyes -Category 2 Aquatic Toxicity – Flammable – Category- 2 Category 3 NA: Not available GHS Category table for reference Study/hazard Category 1 Category 2 Category 3 Category 4 Category 5 statement Acute Oral mg/kg < 50 mg/kg 50 < 300 mg/kg 300 < 2000 2000 LD50 Fatal if swallowed Toxic if swallowed mg/kg 5000mg/kg Harmful if May be harmful if swallowed Acute Dermal 50 mg/kg 50 < 200 mg/kg 200 < 1000 1000 < 2000 < 5000 mg/kg LD50 Fatal in contact with Fatal in contact mg/kg 2000 mg/kg May be skin with skin Toxic in contact with Harmful in harmful in skin contact with contact with skin skin Acute Inhalation See footnote Dust LC50 below this Gases LC50 0.05 mg/L 0.05 < 0.5 mg/L 0.5< 1 mg/L 1.0< 5 mg/L table Vapours LC50 100 ppm/V 100 < 500 500 < 2500 ppm/V > 2500 < 20000 mg/L ppm/V 2.0 < 10 mg/L Toxic ppm/V Fatal if inhaled < 2.0 mg/L if inhaled < 20 mg/L Fatal if inhaled Harmful if inhaled Flammable Flash point < 23 Flash point ≥ 23 Flash point ≥ 60 Not Applicable Liquids degrees C and initial degrees C and initial degrees C ≤ 60 degrees C ≤ 93 boiling point < 35 boiling point > 35 degrees C degrees C. Extremely degrees C. Highly Flammable liquid and Combustible liquid flammable liquid and flammable liquid and vapour vapour Note: Gases concentration are expressed in parts per million per volume (ppmV) NOTE 1: Category 5 is for mixtures which are of relatively low acute toxicity but which under certain circumstances may pose a hazard to vulnerable populations. These mixtures are anticipated to have an oral or dermal LD50 value in the range of 2000-5000 mg/kg bodyweight or equivalent dose for other routes of exposure. In light of animal welfare considerations, testing in animals in Category 5 ranges is discouraged and should only be considered when there is a strong likelihood that results of such testing would have a direct relevance for protecting human health NOTE 2: These values are designed to be used in the calculation of the ATE for classification of a mixture based on its ingredients and do not represent test results. The values are conservatively set at the lower end of the range of Categories 1 and 2, and at a point approximately 1/10th from the lower end of the range for Categories 3 – 5 GHS Category table for reference: Continued Study/hazard Category 1 Category 2 Category 3 statement Eye Irritation Effects on the cornea, iris or 2A: Effects on the cornea, iris or Not applicable conjunctiva that are not expected to conjunctiva that fully reverse within 21 reverse or that have not fully days reversed within 21 days Causes severe eye irritation. 2B Causes severe eye damage Effects on the cornea, iris or conjunctiva that fully reverse within days Causes eye irritation Skin Irritation Destruction of skin tissue, with Mean value of >2.3 > 4.0 for erythema / Mean value of >1.5 < 2.3 for sub categorization based on eschar or edema in at least 2 of 3 tested erythema / eschar or edema in exposure of up to 3 minutes (A), 1 animals from gradings at 24, 48, and 72 at least 2 of 3 tested animals hour (B), or 4 hours (C) hours (or on 3 consecutive days after from gradings at 24, 48, and 72 Causes severe skin burns and eye onset if reactions are delayed); hours (or on 3 consecutive damage inflammation that persists to end of the days after onset if reactions are normally 14-day) observation period delayed) Causes skin irritation Causes mild skin irritation

Environmental hazards

96 hr LC50 (fish) <1 mg/L 48 hr 96 hr LC50 (fish) >1< 10 mg/L 48 hr 96 hr LC50 (fish) >10< 100 Acute Toxicity EC50 (crustacea) < 1 mg/L, 72/96 EC50 (crustacea) >1< 10 mg/L 72/96 hr mg/L 48 hr EC50 (crustacea) Category hr ErC50 (aquatic plants) < 1 mg/L ErC50 (aquatic plants) >1< 10 mg/L 10< 100 mg/L 72/96 hr Very toxic to aquatic life Toxic to aquatic life ErC50 (aquatic plants) >10< 100 mg/L Harmful to aquatic life Flammable Extremely flammable aerosol Flammable aerosol Not Applicable Aerosol Flammable Using the burning rate test, Using the burning rate test, substances Not Applicable solids substances or mixtures other than or mixtures other than metal powders metal powders: (a) wetted zone does wetted zone does not stop fire for at not stop fire and least 4 minutes and (b) burning time < burning time < 45 seconds or 45 seconds or burning rate > 2.2 burning rate > 2.2 mm/second mm/second Using the burning rate test, Using the burning rate test, metal metal powders that have burning time > powders that have burning time < 5 < 10 minutes minutes Flammable solid Flammable Gases, which at 20 degrees C and a Gases, other than those of category 1, Not Applicable gases standard pressure of 101.3 kPA which, at 20 degrees C and a standard are ignitable when in a mixture pressure of 101.3 kPA, have a of 13% or less by volume in air; or flammable range while mixed in air have a flammable range with air Flammable gas of at least 12 percentage points regardless of the lower flammable limit Extremely flammable gas NA

2.2 Label elements

GHS02 Flame GHS 07 Warning GHS 09 Environmental Hazard

Hazard statements

H226: Flammable liquid and vapor H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard] H315: Causes skin irritation H318: Causes serious eye damage [Danger Serious eye damage/eye irritation H411: Toxic to aquatic life with long lasting effects P210: Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting equipment. Precautionary P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. Immediately closed. NFPA HAZARD CODES RATINGS SYSTEM HEALTH: 2 0 = No Hazard FLAMMABILITY: 2 1 = Slight Hazard INSTABILITY: 0 2 = Moderate Hazard 3 = Serious Hazard 4 = Severe Hazard 2.2 Information pertaining to particular dangers for human: May be harmful if inhaled. Irritating to eyes, skin and respiratory organs. 2.3 Information pertaining to particular dangers for the

Prevention

P264: Wash thoroughly after handling. P273: Avoid release to the environment. P280: Wear protective gloves/protective clothing/eye protection/face protection. P264+P265: Wash hands thoroughly after handling. Do not touch eyes. Precautionary P301+P316 - IF SWALLOWED Get emergency medical help

Response

P303 +P361 + P353 IF ON SKIN (or hair) Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 - Immediately rinse with water for several minutes. Remove contact lenses if present. Continue rinsing P317: Get emergency medical help. P321: Specific treatment reference to first aid instruction P331: Do NOT induce vomiting. P332+P317 If skin irritation occurs Get medical help P362+P364; Take off contaminated clothing and wash it before reuse P370 + P378 In case of fire Use FOAM for extinguisher P302 + P352 IF ON SKIN Wash with plenty of soap and water P305 + P351 + P338 IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present. Continue rinsing. Precautionary P403+P233: Store in a well-ventilated place. Keep container tightly

Storage

P405: Store locked up. P403+P235: Store in a well-ventilated place. Keep cool. Precautionary Follow local regulation

Other hazards

Flammable and Ignition possible when exposed to hot surfaces, sparks, naked flames and by electrostatic discharges too.

Principle Routes of Exposure

Those with history of lung diseases, or skin problems may be more susceptible to the effect of this material. Skin Contact Skin Absorption Eye Contact Inhalation Ingestion Yes DATA REFERENCE: https://pubchem.ncbi.nlm.nih.gov/compound/1_4- diethylbenzene#section=Probable-Routes-of-Human-Exposure

Health hazards

Source NTP listed? IARC cancer review group?

2.1 Classification of the substance or mixture

and category code. GHS Category: Health Environmental Physical Irritating to eyes -Category 2 Aquatic Toxicity – Flammable – Category- 2 Category 3 NA: Not available GHS Category table for reference: Study/hazard Category 1 Category 2 Category 3 Category 4 Category 5 statement Acute Oral < 5 mg/kg > 5 < 50 mg/kg > 50 < 300 mg/kg > 300 < 2000 > 2000 LD50 Fatal if swallowed Toxic if swallowed mg/kg <5000mg/kg Harmful if May be harmful if swallowed Acute Dermal < 50 mg/kg > 50 < 200 mg/kg > 200 < 1000 > 1000 < > 2000 < 5000 mg/kg LD50 Fatal in contact with Fatal in contact mg/kg 2000 mg/kg May be skin with skin Toxic in contact with Harmful in harmful in skin contact with contact with skin skin Acute Inhalation See footnote Dust LC50 below this Gases LC50 < 0.05 mg/L > 0.05 < 0.5 mg/L > 0.5< 1 mg/L > 1.0< 5 mg/L table Vapours LC50 < 100 ppm/V > 100 < 500 > 500 < 2500 ppm/V > 2500 < 20000 <0.5 mg/L ppm/V >2.0 < 10 mg/L Toxic ppm/V Fatal if inhaled >0.5 < 2.0 mg/L if inhaled >10 < 20 mg/L Fatal if inhaled Harmful if inhaled Flammable Flash point < 23 Flash point ≥ 23 Flash point ≥ 60 Not Applicable Liquids degrees C and initial degrees C and initial degrees C ≤ 60 degrees C ≤ 93 boiling point < 35 boiling point > 35 degrees C. degrees C. Extremely degrees C. Highly Flammable liquid and Combustible liquid flammable liquid and flammable liquid and vapour vapour Note: Gases concentration are expressed in parts per million per volume (ppmV). NOTE 1: Category 5 is for mixtures which are of relatively low acute toxicity but which under certain circumstances may pose a hazard to vulnerable populations. These mixtures are anticipated to have an oral or dermal LD50 value in the range of 2000-5000 mg/kg bodyweight or equivalent dose for other routes of exposure. In light of animal welfare considerations, testing in animals in Category 5 ranges is discouraged and should only be considered when there is a strong likelihood that results of such testing would have a direct relevance for protecting human health. NOTE 2: These values are designed to be used in the calculation of the ATE for classification of a mixture based on its ingredients and do not represent test results. The values are conservatively set at the lower end of the range of Categories 1 and 2, and at a point approximately 1/10th from the lower end of the range for Categories 3 – 5. GHS Category table for reference: Continued Study/hazard Category 1 Category 2 Category 3 statement Eye Irritation Effects on the cornea, iris or 2A: Effects on the cornea, iris or Not applicable conjunctiva that are not expected to conjunctiva that fully reverse within 21 reverse or that have not fully days. reversed within 21 days. Causes severe eye irritation. 2B : Causes severe eye damage. Effects on the cornea, iris or conjunctiva that fully reverse within 7 days. Causes eye irritation. Skin Irritation Destruction of skin tissue, with Mean value of >2.3 > 4.0 for erythema / Mean value of >1.5 < 2.3 for sub categorization based on eschar or edema in at least 2 of 3 tested erythema / eschar or edema in exposure of up to 3 minutes (A), 1 animals from gradings at 24, 48, and 72 at least 2 of 3 tested animals hour (B), or 4 hours (C). hours (or on 3 consecutive days after from gradings at 24, 48, and 72 Causes severe skin burns and eye onset if reactions are delayed); hours (or on 3 consecutive damage. inflammation that persists to end of the days after onset if reactions are (normally 14-day) observation period. delayed). Causes skin irritation. Causes mild skin irritation. Environment: 96 hr LC50 (fish) <1 mg/L 48 hr 96 hr LC50 (fish) >1< 10 mg/L 48 hr 96 hr LC50 (fish) >10< 100 Acute Toxicity EC50 (crustacea) < 1 mg/L, 72/96 EC50 (crustacea) >1< 10 mg/L 72/96 hr mg/L 48 hr EC50 (crustacea) Category hr ErC50 (aquatic plants) < 1 mg/L ErC50 (aquatic plants) >1< 10 mg/L >10< 100 mg/L 72/96 hr Very toxic to aquatic life Toxic to aquatic life ErC50 (aquatic plants) >10< 100 mg/L Harmful to aquatic life Flammable Extremely flammable aerosol Flammable aerosol Not Applicable Aerosol Flammable Using the burning rate test, Using the burning rate test, substances Not Applicable solids substances or mixtures other than or mixtures other than metal powders: metal powders: (a) wetted zone does (a) wetted zone does not stop fire for at not stop fire and least 4 minutes and (b) burning time < (b) burning time < 45 seconds or 45 seconds or burning rate > 2.2 burning rate > 2.2 mm/second mm/second Using the burning rate test, Using the burning rate test, metal metal powders that have burning time > powders that have burning time < 5 5 < 10 minutes minutes Flammable solid Flammable Gases, which at 20 degrees C and a Gases, other than those of category 1, Not Applicable gases standard pressure of 101.3 kPA: which, at 20 degrees C and a standard (a) are ignitable when in a mixture pressure of 101.3 kPA, have a of 13% or less by volume in air; or flammable range while mixed in air. (b) have a flammable range with air Flammable gas of at least 12 percentage points regardless of the lower flammable limit. Extremely flammable gas GHS Label: GHS02 Flame GHS 07 Warning GHS 09 Environmental Hazard Hazard H226: Flammable liquid and vapor Statements H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]