CYCLOHEXANE

Hazard statements (CLP)

H225, H304, H315, H336, H400, H410

Code

Statements

H225

Highly Flammable liquid and vapour

SECTION 2: Hazards identification

OSHA Classification of the substance/mixture: Hazard class and category code

Hazard categories

Health Environmental Physical Aspiration toxicity: Category 1 Aquatic Acute 1 Flammable – Skin irritation: Category 2 Aquatic Chronic 1 Category 2 Specific Target Organ Toxicity (SE): 3 NA: Not available, SE: Single Exposure Data reference: http://ecb.jrc.ec.europa.eu/esis/, Official Journal of the European Union regarding EU GHS GHS Category table for reference Study/hazard Category 1 Category 2 Category 3 Category 4 Category 5 statement Acute Oral mg/kg < 50 mg/kg 50 < 300 mg/kg 300 < 2000 2000 < LD50 Fatal if swallowed Toxic if swallowed mg/kg 5000mg/kg Harmful if May be harmful swallowed if swallowed Acute Dermal 50 mg/kg 50 < 200 mg/kg 200 < 1000 1000 < 2000 2000 < 5000 LD50 Fatal in contact with Fatal in contact mg/kg mg/kg May be skin with skin Toxic in contact Harmful in contact harmful in with skin contact with skin Acute See footnote Inhalation below this table Dust LC50 0.05 mg/L 0.05 < 0.5 mg/L < 1.0 mg/L 1.0 < 5 mg/L Gases LC50 100 ppm/V 100 < 500 ppm/V 500 < 2500 2500 < 20000 Vapours LC50 mg/L < 2.0 mg/L ppm/V Fatal if inhaled 2.0 < 10 mg/L < 20 mg/L Toxic if inhaled Harmful if inhaled Flammable Flash point < 23 Flash point > 23 Flash point > 60 Not Applicable liquids degrees C and initial degrees C and degrees C< 60 degrees C < 93 boiling point < 35 initial boiling point degrees C degrees C. Extremely 35 degrees C Flammable liquid Combustible liquid flammable liquid and Highly flammable and vapour vapour liquid and vapour Note: Gases concentration are expressed in parts per million per volume (ppm/V) NOTE 1: Category 5 is for mixtures which are of relatively low acute toxicity but which under certain circumstances may pose a hazard to vulnerable populations. These mixtures are anticipated to have an oral or dermal LD50 value in the range of 2000-5000 mg/kg bodyweight or equivalent dose for other routes of exposure. In light of animal welfare considerations, testing in animals in Category 5 ranges is discouraged and should only be considered when there is a strong likelihood that results of such testing would have a direct relevance for protecting human health NOTE 2: These values are designed to be used in the calculation of the ATE for classification of a mixture based on its ingredients and do not represent test results. The values are conservatively set at the lower end of the range of Categories 1 and 2, and at a point approximately 1/10th from the lower end of the range for Categories 3 – 5 GHS Category table for reference: Continued Study/hazard Category 1 Category 2 Category 3 statement Eye Irritation Effects on the cornea, iris or 2A: Effects on the cornea, iris or Not applicable conjunctiva that are not expected to conjunctiva that fully reverse within 21 reverse or that have not fully days reversed within 21 days Causes severe eye irritation Causes severe eye damage 2B Effects on the cornea, iris or conjunctiva that fully reverse within 7 days Causes eye irritation Skin Irritation Destruction of skin tissue, with Mean value of >2.3 > 4.0 for erythema / Mean value of >1.5 < 2.3 sub categorization based on eschar or edema in at least 2 of 3 tested for erythema / eschar or exposure of up to 3 minutes (A), 1 animals from gradings at 24, 48, and 72 edema in at least 2 of 3 hour (B), or 4 hours (C) hours (or on 3 consecutive days after tested animals from gradings Causes severe skin burns and eye onset if reactions are delayed); at 24, 48, and 72 hours (or on 3 damage inflammation that persists to end of the consecutive days after onset if normally 14-day) observation period reactions are delayed) Causes skin irritation Causes mild skin irritation

Environmental hazards

96 hr LC50 (fish) <1 mg/L 48 hr 96 hr LC50 (fish) >1< 10 mg/L 48 hr 96 hr LC50 (fish) >10< 100 Acute Toxicity EC50 (crustacea) < 1 mg/L, 72/96 EC50 (crustacea) >1< 10 mg/L 72/96 hr mg/L 48 hr EC50 (crustacea) Category hr ErC50 (aquatic plants) < 1 mg/L ErC50 (aquatic plants) >1< 10 mg/L 10< 100 mg/L 72/96 hr Very toxic to aquatic life Toxic to aquatic life ErC50 (aquatic plants) >10< 100 mg/L Harmful to aquatic life Flammable Extremely flammable aerosol Flammable aerosol Not Applicable Aerosol Flammable Using the burning rate test, Using the burning rate test, substances Not Applicable solids substances or mixtures other than or mixtures other than metal powders metal powders: (a) wetted zone does wetted zone does not stop fire for at not stop fire and least 4 minutes and (b) burning time < burning time < 45 seconds or 45 seconds or burning rate > 2.2 burning rate > 2.2 mm/second mm/second Using the burning rate test, Using the burning rate test, metal metal powders that have burning time > powders that have burning time < 5 < 10 minutes minutes Flammable solid Flammable Gases, which at 20 degrees C and a Gases, other than those of category 1, Not Applicable gases standard pressure of 101.3 kPA which, at 20 degrees C and a standard are ignitable when in a mixture pressure of 101.3 kPA, have a of 13% or less by volume in air; or flammable range while mixed in air have a flammable range with air Flammable gas of at least 12 percentage points regardless of the lower flammable limit Extremely flammable gas

2.2 Label elements

GHS02 Flame, GHS08 Carcinogen, GHS07 Warning, GHS09: Environmental Toxicity,

Signal word

Danger Details of statements

Hazard statements

H225: Highly flammable liquid and vapour. H304: May be fatal if swallowed and enters airways. H315: Causes skin irritation. H336: May cause drowsiness or dizziness. H400: Very toxic to aquatic life. H410: Toxic to aquatic life. Precautionary P 102: Keep out of reach of children. P 103: Read label before use. at hand. P 403+P235: Store in a well-ventilated place. Keep cool. unwell. NFPA HAZARD CODES RATINGS SYSTEM HEALTH: 1 0 = No Hazard FLAMMABILITY: 3 1 = Slight Hazard INSTABILITY: 0 2 = Moderate Hazard 3 = Serious Hazard 4 = Severe Hazard 2.2 Information pertaining to particular dangers for human: Product irritates Respiratory track, eyes and skin. The substance may cause effects on the central nervous system. Exposure could cause lowering of consciousness. Repeated or prolonged contact with skin may cause dryness and cracking and dermatitis. 2.3 Information pertaining to particular dangers for the environment: Possible adverse effects on aquatic organisms.

Prevention

P210: Keep away from heat/sparks/open flames/hot surfaces* No smoking. P233: Keep container tightly closed. P 240: Ground/bond container and receiving equipment. P 241: Use explosion-proof electrical/ventilating/lighting/ equipment. P 242: Use only non-sparking tools. P 243: Take precautionary measures against static discharge. P 261: Avoid breathing dust/fume/gas/mist/vapours/spray*. P 264: Wash thoroughly after handling. P 271: Use only outdoors or in a well-ventilated area. P273: Avoid release to the environment. P280: Wear protective gloves/protective Clothing/eye protection/face protection/hearing protection Precautionary P 101: If medical advice is needed, have product container or label

Response

P301+P316 IF SWALLOWED Get emergency medical help immediately P303+P361+P353 IF ON SKIN (or hair) Remove/Take off immediately all contaminated clothing. Rinse skin with Water/shower. P370+P378 In case of fire Use foam for extinction P302+P352 IF ON SKIN Wash with plenty of soap and water P321: Specific treatment see label P331: Do NOT induce vomiting P332+P313 If skin irritation occurs Get medical advice/ attention. P362+ P364: Take off contaminated clothing and wash before re-use. P304+P340 IF INHALED Remove to fresh air and keep at rest in a position comfortable for breathing. P319: Get medical help if you feel unwell. P391: Collect spillage. Precautionary P405: Store locked up.

Storage

Precautionary P312: Call a POISON CENTER or doctor/physician if you feel Follow local regulation

Disposal

P391: Collect spillage. Data reference: Official Journal of the European Union regarding EU GHS

Other hazards

Highly flammable and easily ignitable substance. Danger of ignition at normal temperature. Readily evaporates and vapours form with air toxic and explosive mixtures heavier than air. Mixtures keep above ground and after ignition they spread fast into far distances. Ignition possible when exposed to hot surfaces, sparks, naked flames and by electrostatic discharges too. The substance is practically insoluble in water, floats on the water level and forms toxic and explosive mixtures above the water level. Risk of explosion if emptied into drains or released into wastewater. Target Organs: Eyes, skin, respiratory system, central nervous system

Principle Routes of Exposure

Skin Contact Skin Absorption Eye Contact Inhalation Ingestion Yes DATA REFERENCE: http://toxnet.nlm.nih.gov/cgibin/sis/search.

Health hazards

Source NTP listed? IARC cancer review group?

2.1 Classification of the substance or mixture

code. GHS Category: Health Environmental Physical Aspiration toxicity: Category 1 Aquatic Acute 1 Flammable – Skin irritation: Category 2 Aquatic Chronic 1 Category 2 Specific Target Organ Toxicity (SE): 3 NA: Not available, SE: Single Exposure. Data reference: http://ecb.jrc.ec.europa.eu/esis/, Official Journal of the European Union regarding EU GHS GHS Category table for reference: Study/hazard Category 1 Category 2 Category 3 Category 4 Category 5 statement Acute Oral < 5 mg/kg > 5 < 50 mg/kg > 50 < 300 mg/kg > 300 < 2000 > 2000 < LD50 Fatal if swallowed Toxic if swallowed mg/kg 5000mg/kg Harmful if May be harmful swallowed if swallowed Acute Dermal < 50 mg/kg > 50 < 200 mg/kg > 200 < 1000 > 1000 < 2000 > 2000 < 5000 LD50 Fatal in contact with Fatal in contact mg/kg mg/kg May be skin with skin Toxic in contact Harmful in contact harmful in with skin contact with skin Acute See footnote Inhalation below this table Dust LC50 < 0.05 mg/L > 0.05 < 0.5 mg/L > 0.5 < 1.0 mg/L > 1.0 < 5 mg/L Gases LC50 < 100 ppm/V > 100 < 500 ppm/V > 500 < 2500 >2500 < 20000 Vapours LC50 <0.5 mg/L >0.5 < 2.0 mg/L ppm/V Fatal if inhaled > 2.0 < 10 mg/L > 10 < 20 mg/L Toxic if inhaled Harmful if inhaled Flammable Flash point < 23 Flash point > 23 Flash point > 60 Not Applicable liquids degrees C and initial degrees C and degrees C< 60 degrees C < 93 boiling point < 35 initial boiling point degrees C. degrees C. Extremely > 35 degrees C. Flammable liquid Combustible liquid flammable liquid and Highly flammable and vapour vapour liquid and vapour Note: Gases concentration are expressed in parts per million per volume (ppm/V). NOTE 1: Category 5 is for mixtures which are of relatively low acute toxicity but which under certain circumstances may pose a hazard to vulnerable populations. These mixtures are anticipated to have an oral or dermal LD50 value in the range of 2000-5000 mg/kg bodyweight or equivalent dose for other routes of exposure. In light of animal welfare considerations, testing in animals in Category 5 ranges is discouraged and should only be considered when there is a strong likelihood that results of such testing would have a direct relevance for protecting human health. NOTE 2: These values are designed to be used in the calculation of the ATE for classification of a mixture based on its ingredients and do not represent test results. The values are conservatively set at the lower end of the range of Categories 1 and 2, and at a point approximately 1/10th from the lower end of the range for Categories 3 – 5. GHS Category table for reference: Continued Study/hazard Category 1 Category 2 Category 3 statement Eye Irritation Effects on the cornea, iris or 2A: Effects on the cornea, iris or Not applicable conjunctiva that are not expected to conjunctiva that fully reverse within 21 reverse or that have not fully days. reversed within 21 days. Causes severe eye irritation. Causes severe eye damage. 2B : Effects on the cornea, iris or conjunctiva that fully reverse within 7 days. Causes eye irritation. Skin Irritation Destruction of skin tissue, with Mean value of >2.3 > 4.0 for erythema / Mean value of >1.5 < 2.3 sub categorization based on eschar or edema in at least 2 of 3 tested for erythema / eschar or exposure of up to 3 minutes (A), 1 animals from gradings at 24, 48, and 72 edema in at least 2 of 3 hour (B), or 4 hours (C). hours (or on 3 consecutive days after tested animals from gradings Causes severe skin burns and eye onset if reactions are delayed); at 24, 48, and 72 hours (or on 3 damage. inflammation that persists to end of the consecutive days after onset if (normally 14-day) observation period. reactions are delayed). Causes skin irritation. Causes mild skin irritation. Environment: 96 hr LC50 (fish) <1 mg/L 48 hr 96 hr LC50 (fish) >1< 10 mg/L 48 hr 96 hr LC50 (fish) >10< 100 Acute Toxicity EC50 (crustacea) < 1 mg/L, 72/96 EC50 (crustacea) >1< 10 mg/L 72/96 hr mg/L 48 hr EC50 (crustacea) Category hr ErC50 (aquatic plants) < 1 mg/L ErC50 (aquatic plants) >1< 10 mg/L >10< 100 mg/L 72/96 hr Very toxic to aquatic life Toxic to aquatic life ErC50 (aquatic plants) >10< 100 mg/L Harmful to aquatic life Flammable Extremely flammable aerosol Flammable aerosol Not Applicable Aerosol Flammable Using the burning rate test, Using the burning rate test, substances Not Applicable solids substances or mixtures other than or mixtures other than metal powders: metal powders: (a) wetted zone does (a) wetted zone does not stop fire for at not stop fire and least 4 minutes and (b) burning time < (b) burning time < 45 seconds or 45 seconds or burning rate > 2.2 burning rate > 2.2 mm/second mm/second Using the burning rate test, Using the burning rate test, metal metal powders that have burning time > powders that have burning time < 5 5 < 10 minutes minutes Flammable solid Flammable Gases, which at 20 degrees C and a Gases, other than those of category 1, Not Applicable gases standard pressure of 101.3 kPA: which, at 20 degrees C and a standard (a) are ignitable when in a mixture pressure of 101.3 kPA, have a of 13% or less by volume in air; or flammable range while mixed in air. (b) have a flammable range with air Flammable gas of at least 12 percentage points regardless of the lower flammable limit. Extremely flammable gas GHS Label: GHS02: Flame, GHS08: Carcinogen, GHS07: Warning, GHS09: Environmental Toxicity, Signal word: Danger Details of statements: Hazard H225: Highly flammable liquid and vapour. Statements H304: May be fatal if swallowed and enters airways.