Benzo[k]fluoranthene

SECTION 2: Hazards identification

Flammability Toxicity Body Contact Reactivity Chronic 0 1 2 3 4 Min Low Moderate High Extreme ANSI Signal Word Warning! wowewveve Emergency Overview * % % ve | Pale yellow needles. Irritating to eyes/skin/respiratory tract. Toxic. Probable human carcinogen. Will burn.

Potential health effects

Target Organs: eyes, skin, respiratory system

Principle Routes of Exposure

skin contact/absorption, inhalation of generated dust Acute Effects Inhalation: The dust may be discomforting to the upper respiratory tract. Persons with impaired respiratory function, airway diseases, or conditions such as emphysema or chronic bronchitis may incur further disability if excessive concentrations of particulate are inhaled. Eye: The material is moderately discomforting to the eyes and is capable of causing a mild, temporary redness of the conjunctiva (similar to wind-burn), temporary impairment of vision and/ or other transient eye damage/ ulceration. Skin: The material may be mildly discomforting to the skin. Open cuts and abraded or irritated skin should not be exposed to this material. The material may accentuate any pre-existing skin condition. Ingestion: Considered an unlikely route of entry in commercial/industrial environments. The material is moderately discomforting and harmful if swallowed in large quantity. Carcinogenicity: NTP - Listed; IARC - Group 2B, Possibly carcinogenic to humans; OSHA - Not listed; NIOSH - Not listed; ACGIH - Not listed; EPA - Class B2, Probable human carcinogen based on animal studies; MAK - Not listed.

Potential chronic health

When injected into pulmonary tissue of female rats benzo[k]fluoranthene induced squamous cell carcinomas. Topical administration initiated skin tumors in female mice whilst subcutaneous injection induced local sarcomas in mice of both sexes. Although there is no adequate data available to evaluate carcinogenicity of PAHs in Copyright © 2006 by Genium Group, Inc. Any commercial use or reproduction without the publisher’s permission is prohibited. Judgments as to the suitability of information herein for the purchaser’ s purposes are necessarily the purchaser’s responsibility. Although reasonable care has been taken in the preparation of such information, Genium Group, Inc. extends no warranties, makes no representations, and assumes no responsibility as to the accuracy or suitability of such information for application to the purchaser’s intended purpose or for consequences of its use. humans, there are a number of epidemiologic and mortality studies to show increased incidences of cancer in humans exposed to mixtures of PAHs. Lung and genitourinary cancer mortality amongst coke oven workers and skin tumors in workers exposed to creosote are examples.