Acetone

SECTION 2: Hazards identification

ChemWatch Hazard Ratings HMIS 3 Flammability 1 Health Toxicity 1 0 Body Contact 3 Flammability Reactivity — 0 Reactivity Chronic 0 1 2 3 4 Fire Diamond Min Low Moderate High Extreme ANSI Signal Word Danger! Flammable !!!!! Emergency Overview !!!!! Colorless, highly volatile liquid; sweet odor. Irritating. Other Acute Effects: muscle weakness, mentaI confusion, coma (high concentrations). Ingestion: GI irritation, kidney/liver damage, metabolic changes, coma. Chronic Effects: dermatitis. Highly flammable.

Potential health effects

Target Organs: respiratory system, central nervous system (CNS), skin

Principle Routes of Exposure

inhalation, skin contact, eye contact, ingestion Acute Effects Inhalation: The vapor is discomforting to the upper respiratory tract. Copyright © 2006 by Genium Group, Inc. Any commercial use or reproduction without the publisher’s permission is prohibited. Judgments as to the suitability of information herein for the purchaser’s purposes are necessarily the purchaser’s responsibility. Although reasonable care has been taken in the preparation of such information, Genium Group, Inc. extends no warranties, makes no representations, and assumes no responsibility as to the accuracy or suitability of such information for application to the purchaser’s intended purpose or for consequences of its use. Inhalation hazard is increased at higher temperatures. Exposure to ketone vapors may produce nose, throat and mucous membrane irritation. High concentrations of vapor may produce central nervous system depression characterized by headache, vertigo, loss of coordination, narcosis and cardiorespiratory failure. Some ketones produce neurological disorders (polyneuropathy) characterized by bilateral symmetrical paresthesia and muscle weakness primarily in the legs and arms. Symptoms of exposure may include restlessness, headache, vomiting, stupor, low blood pressure and rapid and irregular pulse, eye and throat irritation, weakness of the legs, dizziness and lightheadedness. Inhalation of high concentrations produces dryness of the mouth and throat, dizziness, nausea, incoordinated movements, loss of coordinated speech, drowsiness, and in extreme cases, coma. Inhalation of acetone vapors over long periods causes irritation of the respiratory tract, coughing, headache. Acetone concentrations of 52200 ppm for 1 hour produced narcosis in rats and fatalities at 126600 ppm. Eye: The liquid may produce eye discomfort and is capable of causing temporary impairment of vision and/or transient eye inflammation, ulceration. The vapor is discomforting to the eyes. The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis. Skin: The liquid is discomforting to the skin if exposure is prolonged and may cause drying of the skin, which may lead to dermatitis. Toxic effects may result from skin absorption. Open cuts, abraded or irritated skin should not be exposed to this material. The material may accentuate any pre-existing skin condition. The material may cause skin irritation after prolonged or repeated exposure and may produce a contact dermatitis (nonallergic). This form of dermatitis is often characterized by skin redness (erythema) and swelling (edema) which may progress to vesiculation, scaling and thickening of the epidermis. Histologically there may be intercellular edema of the spongy layer (spongiosis) and intracellular edema of the epidermis. Ingestion: Considered an unlikely route of entry in commercial/industrial environments. The liquid is highly discomforting and mildly toxic if swallowed but may be harmful if swallowed in quantity. Small amounts or low dose rates are regarded as practically non-harmful. Carcinogenicity NTP - Not listed; IARC - Not listed;

Potential chronic health

Prolonged or continuous skin contact with the liquid may cause defatting with drying, cracking, irritation and dermatitis following. Workers exposed to 700 ppm acetone for 3 hours/day for 7-15 years showed inflammation of the respiratory tract, stomach and duodenum, attacks of giddiness and loss of strength. Exposure to acetone may enhance liver toxicity of chlorinated solvents.