RAL 2004

Health hazards

powder mixture) May cause skin and eye irritation. May cause irritation of the upper respiratory tract (nose, mouth and/or throat), resulting in sneezing coughing and sore throat. Long-term respiratory exposure exceeding exposure limits may damage the lungs, leading to impairment of lung capacity. The acute and chronic health effect statements below are for the pure chemicals only, unless noted. MSDS -----------------------------------------------------------------------------

Potential Acute Health Effects

1,3,5-Triglycidyl Isocyanurate) INGESTION: Moderately toxic. Symptoms are not fully known, may include loss of appetite and nose bleeding. INHALATION: Irritating to upper respiratory tract. May cause nosebleeds. EYE CONTACT: Irritating. SKIN CONTACT: Irritating. Can be absorbed through the skin in harmful amounts. Effects similar to ingestion. A COMMERCIAL POLYESTER POWDER MIXTURE CONTAINING 5% TGIC WAS TESTED IN RATS (SAFEPHARM (UK) 1998) FOR ACUTE ORAL TOXICITY WITH THE FOLLOWING RESULTS: LD50:>5000 mg/Kg (m/f) (BARIUM SULFATE) Inhalation of dusts containing barium sulfate may be irritating to the respiratory tract. Contact with the eyes may also cause irritation. In 1994, US EPA deleted barium sulfate from the category "barium compounds" on the list of toxic chemicals for which reporting is required. The final rule is in 40 CFR Part 372. (TITANIUM DIOXIDE) INGESTION: Low oral toxicity. No toxic effects due to ingestion are described in literature. INHALATION: Irritating to upper respiratory tract. EYE CONTACT: Irritating.

Potential chronic health

1,3,5-Triglycidyl Isocyanurate) Irritation of eyes, skin and respiratory tract; loss of appetite, may cause nosebleeds; toxic by ingestion and if absorbed through the skin. Prolonged or repeated contact may cause skin sensitization. TGIC has shown mutagenic activity in laboratory cells culture test and laboratory animals. Based on those studies, TGIC has been classified as "Possible Human Germ Cell Mutagen", and capable of causing permanent heritable damage in reproductive cells on humans. Overexposure can result in toxic effects on liver and lungs. (BARIUM SULFATE) Prolonged exposure could cause benign pneumoconiosis called Baritosis. (TITANIUM DIOXIDE) Laboratory studies show that inhalation exposure to high levels (250 mg/kg) of Titanium Dioxide causes cancerous tumors in rats. This response occurs at lower exposure levels and may be due to the high levels overwhelming normal lung clearance mechanisms. The relevance of this data to humans is not significant where the TLV is observed. MEDICAL CONDITIONS PRONE TO AGGRAVATION BY OVEREXPOSURE: (1,3,5-Triglycidyl Isocyanurate) MSDS ----------------------------------------------------------------------------- Respiratory illness & dermatitis may be aggravated by excessive exposure.

Principle Routes of Exposure

Inhalation, Dermal, or Ingestion --------------------------------------------------------------------------------