Titanium Tetrachloride

SECTION 2: Hazards identification

EMERGENCY OVERVIEW DANGER! Corrosive, toxic liquid and vapor. Reacts with water or moisture in the air to form toxic, corrosive gases. Harmful or fatal if inhaled. Harmful if swallowed. Causes severe eye, skin, and respiratory tract burns. Symptoms may be delayed. Self-contained breathing apparatus and protective clothing must be worn by rescue workers. Odor: Pungent, penetrating acid THRESHOLD LIMIT VALUE: TLV-TWA, none currently established (ACGIH, 2004). Copyright © 2000, 2001, 2004, Praxair Technology, Inc. Page 1 of 8 All rights reserved. Revised EFFECTS OF A SINGLE (ACUTE) OVEREXPOSURE: INHALATION–Corrosive vapor. Destroys tissues of the mouth, nose, and throat. Symptoms include a burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Upper respiratory spasms and swelling of tissues in the larynx and bronchial passages may cut off the supply of oxygen to the lungs—lack of oxygen can kill. Death may also result from pulmonary edema (fluid in the lungs) and chemical pneumonia. Surviving victims of inhalation may suffer permanent lung damage. SKIN CONTACT–Liquid spilled or splashed on the skin may cause painful irritation, blistering, and burns. Vapors may severely irritate the skin. SWALLOWING–Corrosive liquid will burn the mouth, throat, and stomach, resulting in throat and abdominal pain, nausea, and vomiting. The liquid and hydrogen chloride gas formed by contact with moisture are poisons. EYE CONTACT–Corrosive vapors irritate the eyes and may damage them. Contact with the liquid may cause severe burns resulting in permanent eye damage. EFFECTS OF REPEATED (CHRONIC) OVEREXPOSURE: Repeated exposure may cause such respiratory conditions as chronic bronchitis and emphysema. Symptoms are coughing and shortness of breath. These conditions are more likely if irritation due to exposure is noticeable. OTHER EFFECTS OF OVEREXPOSURE: None known.

Medical Conditions Generally Aggravated by Exposure

OVEREXPOSURE Exposure may aggravate existing skin, eye, or respiratory problems. SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH HAZARD EVALUATION: Rats inhaling 0.04mg/l for 6 hours per day, 5 days per week, for 4 weeks showed decreased weight gain, respiratory tract inflammation, pulmonary fibrosis, and 8% mortality. Rats given similar treatment at 0.005mg/l showed no effects. A single dermal application in rabbits produced moderate to severe necrosis and edema but no symptoms of toxicity. A lifetime inhalation test found microscopic lung tumors in 5 of 150 rats exposed to 10 mg/m3 titanium tetrachloride. According to the authors, the relevance of tumors of this type to human lung cancer is highly questionable. A 1992 epidemiological study of exposed workers found no significantly higher risk of developing lung cancer than that of unexposed workers. CARCINOGENICITY: This product is not listed by NTP, OSHA, or IARC.