Isoflurane

SECTION 2: Hazards identification

GHS Classification

Physical hazards

Not classified

Health hazards

Skin Irritation – Category 3 Reproductive Toxicity – Category 2 Eye Effects – Category 2A Acute Toxicity (Respiratory) – Category 3 Specific target organ toxicity, single exposure - Category 3 – Narcotic Effects

Signal word

Warning

Hazard statements

H316 – Causes mild skin irritation H319 – Causes serious eye irritation H335 – May cause respiratory irritation H336 – May cause drowsiness or dizziness H361 – Suspected of damaging fertility or the unborn child H373 – May cause damage to organs – repeat exposure

Precautionary statements

P202 – Do not handle until all safety precautions have been read and understood P233 - Keep container tightly closed P260 – Do not breath vapors P264 – Wash thoroughly after handling P271 – Use in well-ventilated area P314 – Get immediate medical advice if you feel unwell P501 – Dispose of contents/container to an approved waste disposal site Non-Dangerous when shipped via ground or water. Dangerous when shipped via air (see section 14) Emergency Overview CAUTION! Anesthetic Agent. Overexposure by inhalation to the vapors may cause temporary nervous system depression with anesthetic effects such as dizziness, headache, confusion, incoordination, or loss of consciousness; they should be moved to an area of fresh air. Concentrations of anesthetic in the air would have to reach approximately 2-3 % before personnel would be expected to experience significant dizziness. Gross overexposure (> 20%) may possibly alter the heart's electrical activity with irregular pulse, palpitations, or inadequate circulation.

Principle Routes of Exposure

Inhalation Inhalation. Skin contact. Eye contact. Ingestion. Practically non-toxic by inhalation. Cardiovascular effects may include fluctuations in heart rate, changes in blood pressure, chest pain. Respiratory effects may include shortness of breath, bronchospasms, laryngospasms, and respiratory depression. Gastrointestinal effects may include nausea, upset stomach, loss of appetite. Nervous system effects may include ataxia, tremor, disturbance of speech, lethargy, headaches, dizziness, blurred vision. Skin Contact: Eye Contact May cause skin irritation. May cause eye irritation. Ingestion Practically non-toxic if swallowed. No specific hazards other than therapeutic effects. See inhalation.

2.1 Classification of the substance or mixture

Physical Hazard: Not classified Health Hazard: Skin Irritation – Category 3 Reproductive Toxicity – Category 2 Eye Effects – Category 2A Acute Toxicity (Respiratory) – Category 3 Specific target organ toxicity, single exposure - Category 3 – Narcotic Effects