Chlorothiazide Sodium for Injection, USP

Hazard statements (CLP)

H315, H317, H319, H334

Code

Statements

H315

Causes skin irritation

Classification (GHS-US)

Comb. Dust Skin Irrit. 2 H315 Eye Irrit. 2A H319 Resp. Sens. 1 H334 Skin Sens. 1 H317

Hazard statements

see section 16 : May form combustible dust concentrations in air. H315 - Causes skin irritation. H317 - May cause an allergic skin reaction. H319 - Causes serious eye irritation. H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled.

2.2 Label elements

GHS-US Labeling

Hazard pictograms

GHS08

Signal word

Danger

Precautionary statements

P261 - Avoid breathing dust. P264 - Wash hands, forearms, and other exposed areas thoroughly after handling. P272 - Contaminated work clothing must not be allowed out of the workplace. P280 - Wear eye protection, protective clothing, protective gloves, respiratory protection. P284 - In case of inadequate ventilation wear respiratory protection . P302+P352 - IF ON SKIN: Wash with plenty of water. P304+P340 - IF INHALED: Remove person to fresh air and keep at rest in a position comfortable for breathing. P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P321 - Specific treatment (see Section 4 on this SDS). P332+P313 - If skin irritation occurs: Get medical advice/attention. P333+P313 - If skin irritation or rash occurs: Get medical advice/attention. P337+P313 - If eye irritation persists: Get medical advice/attention. P342+P311 - If experiencing respiratory symptoms: Call a POISON CENTER, a doctor. P362 - Take off contaminated clothing and wash before reuse. P362+P364 - Take off contaminated clothing and wash it before reuse. P501 - Dispose of contents/container in accordance with local, regional, national, and international regulations.

2.3 Other hazards

Exposure may aggravate those with pre-existing eye, skin, or respiratory conditions. Persons who are hypersensitive to this product or to other sulfonamide‐derived drugs may have an allergic reaction to this drug. Symptoms of an allergic reaction include anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), itching, swelling, dizziness, respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, hives, rash, and purpura. In addition to diuresis and resultant dehydration, overdosage of thiazides (such as Chlorothiazide Sodium) may produce lethargy, nausea, weakness, and electrolyte imbalance; lethargy may progress to coma within a few hours with minimal depression of respiratory and cardiovascular function and without evidence of dehydration or serum electrolyte change. The mechanism of thiazide‐induced CNS depression is unknown. Gastrointestinal irritation and hypermotility may occur, and temporary elevation of the BUN has been reported. Serum electrolyte changes (e.g., hypokalemia, hypochloremia, hyponatremia) may occur, especially in patients with impaired renal function. 2.4.

Ingredient(s) with unknown acute toxicity

No data available