Note: Ingredients listed on restricted chemical lists
EC/CAS
231-595-7/7647-01-0
Name of the chemical
Hydrochloric acid
Concentration
**
EC/CAS
215-185-5/1310-73-2
Name of the chemical
sodium hydroxide
Concentration
**
EC/CAS
200-711-8/69-65-8
Name of the chemical
D-mannitol C6H14O6
Concentration
*
EC/CAS
201-766-0/87-69-4
Name of the chemical
L-(+)-tartaric acid
Concentration
*
EC/CAS
231-791-2/7732-18-5
Name of the chemical
Water, distilled, conductivity or of similar purity H2O
Concentration
*
General Information
Version
1.0
Revision date
2012-01-31
Product name
Topotecan Injection
Product name
Topotecan Injection
Identification on the label/Trade name
Not applicable
Chemical name
Not determined
1.2.1 Relevant identified uses
Pharmaceutical product used as Antineoplastic
Emergency telephone
1-800-424-9300, +1-703-527-3887
Icons in SDS
Company Information
company name
Pfizer Inc
e-mail address of the competent person responsible for the Safety Data Sheet
pfizer-MSDS@pfizer.com
GHS Information
Signal word
DANGER
Hazard Codes
Hazard statements (CLP)
H340, H360D
Hazard statements
Code
Statements
H340
May cause genetic defects
Section 2
SECTION 2: Hazards identification
Appearance Light yellow to Green Lyophilized powder
Signal word
DANGER
Hazard statements
May damage the unborn child. May cause genetic defects.
Additional information
Short Term Accidental ingestion may cause effects similar to those seen in clinical use. Known Clinical Effects Adverse effects associated with therapeutic use include decreased white blood cells (leukopenia), gastrointestinal disturbances, diarrhea, fever, vasodilation, liver enzyme changes, fatigue, weakness, loss of hair, hypersensitivity reactions. EU Classification EU Indication of danger Toxic to Reproduction: Category 2 Mutagenic: Category 2 EU Hazard Symbols EU Risk Phrases R61 - May cause harm to the unborn child. R46 - May cause heritable genetic damage. Australian Hazard Classification (NOHSC)
Hazardous Ingredients
Non-Dangerous Goods Note This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or its intermediates regardless of the potential risk. The precautionary statements and warnings included may not apply in all cases. Your needs may vary depending upon the potential for exposure in your workplace.
2.1 Classification of the substance or mixture
EU Indication of danger: Toxic to Reproduction: Category 2 Mutagenic: Category 2 EU Hazard Symbols: EU Risk Phrases: R61 - May cause harm to the unborn child. R46 - May cause heritable genetic damage. Australian Hazard Classification Hazardous Substance. Non-Dangerous Goods. (NOHSC)
