PetraFlex Primer - PART B

2.1 Classification of the substance or mixture

Acute Oral Toxicity Category 4 Acute Dermal Toxicity Category 4 Acute Vapors Toxicity Category 5 Skin Corrosion Category 1C Eye Irritation Category 2 Skin Sensitizer Category 1 Respiratory Sensitizer Category 1 Germ Cell Mutagenicity Category 2 Carcinogenicity Category 2 TOST: Single Exposure Category 2 TOST: Repeated Exposure Category 2 NFPA ratings (scale 0 – 4): HEALTH 2 FIRE 0 REACTIVITY 2 SPECIAL - NFPA HAZARD RATING: 4= EXTREME 2= MODERATE 0= INSIGNIFICANT 3= HIGH 1= SLIGHT

Signal word

Danger! PHYSICAL APPEARANCE: Dark brown liquid with faint musky odor.

Hazard statements

INHALATION: In a combined chronic inhalation toxicity/oncogenicity study, rats were exposed to an aerosol of polymeric mdi for 6 hours/day, 5 days/week, for one or two years, at exposure concentrations of 0, 0.2, 1.0 and 6.0 mg/m'. Microscopic examination of tissues revealed the effects of irritation to the nasal cavity and lungs in animals exposed to the two highest concentrations. The no observable effect level (noel) was 0.2 mg/m. Pulmonary adenomas and a single pulmonary adenocarcinoma. Were observed in this study, but were considered to be related to mdi. These tumors were observed only in rats exposed at the highest concentration. SKIN AND EYE: Stain for evidence of corneal injury. If cornea is burned, instill antibiotic steroid preparation frequently. Workplace vapors have produced reversible corneal epithelial edema, impairing vision. INGESTION: May cause burning inside the mouth accompanied by nausea, vomiting and diarrhea. HEALTH HAZARDS (ACUTE AND CHRONIC): Repeated skin contact may cause persistent irritation or dermatitis. MUTANGENICITY: Positive (salmonella microsome test with metabolic activation; cell transformation assay) as well as negative (mouse lymphoma specific locus mutation test with or without metabolic activation) results have been observed in vitro. However, mdi gave negative results in an in vivo (mouse micronucleus) assay.

Precautionary statements

Do not breathe dust/fume/gas/mist/vapors/spray. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Get medical advice/attention. IF SWALLOWED: Get immediate medical advice/attention. IF exposed or concerned: Get medical advice/attention. If skin irritation or rash occurs: Get medical advice/attention.